Marc Symons The Feinstein Institute for Medical Research at North Shore-LIJ Biography Publications Institution JoVE Articles Marc Symons has not added a biography. If you are Marc Symons and would like to personalize this page please email our Author Liaison for assistance. Publications Curcumin Changes the Polarity of Tumor-associated Microglia and Eliminates Glioblastoma International Journal of Cancer. Dec, 2016 | Pubmed ID: 27543754 Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma Molecular Cancer Therapeutics. Aug, 2016 | Pubmed ID: 27207779 Radioresistance of Brain Tumors Cancers. 2016 | Pubmed ID: 27043632 Neuro-oncology Biotech Industry Progress Report Journal of Neuro-oncology. May, 2016 | Pubmed ID: 26897014 SGEF Is Regulated Via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Molecular Cancer Research : MCR. Mar, 2016 | Pubmed ID: 26764186 The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma Through Inhibition of Extravasation PloS One. 2015 | Pubmed ID: 26709919 Celecoxib Inhibits Ewing Sarcoma Cell Migration Via Actin Modulation The Journal of Surgical Research. Oct, 2015 | Pubmed ID: 25934222 Synaptojanin 2 is a Druggable Mediator of Metastasis and the Gene is Overexpressed and Amplified in Breast Cancer Science Signaling. Jan, 2015 | Pubmed ID: 25605973 Repurposing Mebendazole for the Treatment of Medulloblastoma Neurosurgery. Feb, 2015 | Pubmed ID: 25594199 Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia PloS One. 2014 | Pubmed ID: 24816734 The Regulation of RhoA at Focal Adhesions by StarD13 is Important for Astrocytoma Cell Motility Experimental Cell Research. Feb, 2014 | Pubmed ID: 24333506 Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression Frontiers in Oncology. 2013 | Pubmed ID: 24109588 The Src Homology 3 Domain-containing Guanine Nucleotide Exchange Factor is Overexpressed in High-grade Gliomas and Promotes Tumor Necrosis Factor-like Weak Inducer of Apoptosis-fibroblast Growth Factor-inducible 14-induced Cell Migration and Invasion Via Tumor Necrosis Factor Receptor-associated Factor 2 The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23775076 The MLK-related Kinase (MRK) is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23319595 Signaling Determinants of Glioma Cell Invasion Advances in Experimental Medicine and Biology. 2013 | Pubmed ID: 22879067 Regulation of Synaptojanin 2 5'-phosphatase Activity by Src Cell Adhesion & Migration. Nov-Dec, 2012 | Pubmed ID: 23076136 The Small GTPase RhoG Mediates Glioblastoma Cell Invasion Molecular Cancer. 2012 | Pubmed ID: 22966858 Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-induced Migration and Invasion of Glioblastoma Cells Molecular Cancer Research : MCR. Jul, 2012 | Pubmed ID: 22571869 Role of a DNA Damage Checkpoint Pathway in Ionizing Radiation-induced Glioblastoma Cell Migration and Invasion Cellular and Molecular Neurobiology. Oct, 2012 | Pubmed ID: 22552889 Microglial Stimulation of Glioblastoma Invasion Involves EGFR and CSF-1R Signaling Molecular Medicine (Cambridge, Mass.). Jan, 2012 | Pubmed ID: 22294205 Glioblastoma with PNET-like Components Has a Higher Frequency of Isocitrate Dehydrogenase 1 (IDH1) Mutation and Likely a Better Prognosis Than Primary Glioblastoma International Journal of Clinical and Experimental Pathology. 2011 | Pubmed ID: 22076165 Rac1 Activation Comes Full Circle The EMBO Journal. Oct, 2011 | Pubmed ID: 21975373 The VEGF/Rho GTPase Signalling Pathway: a Promising Target for Anti-angiogenic/anti-invasion Therapy Drug Discovery Today. Mar, 2011 | Pubmed ID: 21262381 Phosphoinositides Direct Equine Infectious Anemia Virus Gag Trafficking and Release Traffic (Copenhagen, Denmark). Apr, 2011 | Pubmed ID: 21176037 Pak1 and Pak2 Are Activated in Recurrent Respiratory Papillomas, Contributing to One Pathway of Rac1-mediated COX-2 Expression International Journal of Cancer. Nov, 2010 | Pubmed ID: 20131316 Role of Rac1-regulated Signaling in Medulloblastoma Invasion. Laboratory Investigation Journal of Neurosurgery. Pediatrics. Aug, 2009 | Pubmed ID: 19645540 Rac and Rho Driving Tumor Invasion: Who's at the Wheel? Genome Biology. 2009 | Pubmed ID: 19291272 The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma The American Journal of Pathology. Dec, 2008 | Pubmed ID: 19008376 Cell Biology: Watching the First Steps of Podosome Formation Current Biology : CB. Oct, 2008 | Pubmed ID: 18957242 The Arthritis Severity Locus Cia5d is a Novel Genetic Regulator of the Invasive Properties of Synovial Fibroblasts Arthritis and Rheumatism. Aug, 2008 | Pubmed ID: 18668563 Pak1 and Pak2 Mediate Tumor Cell Invasion Through Distinct Signaling Mechanisms Molecular and Cellular Biology. Jun, 2008 | Pubmed ID: 18411304 RhoA/ROCK-mediated Switching Between Cdc42- and Rac1-dependent Protrusion in MTLn3 Carcinoma Cells Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 Role of Myosin II Activity and the Regulation of Myosin Light Chain Phosphorylation in Astrocytomas Cell Motility and the Cytoskeleton. Jan, 2008 | Pubmed ID: 17896341 The Distinct Roles of Ras and Rac in PI 3-kinase-dependent Protrusion During EGF-stimulated Cell Migration Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 The GTPase Rac Regulates the Proliferation and Invasion of Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients Molecular Medicine (Cambridge, Mass.). May-Jun, 2007 | Pubmed ID: 17622308 Up-regulation of Rac1 by Epidermal Growth Factor Mediates COX-2 Expression in Recurrent Respiratory Papillomas Molecular Medicine (Cambridge, Mass.). Mar-Apr, 2007 | Pubmed ID: 17592548 The Atypical Rho Family GTPase Wrch-1 Regulates Focal Adhesion Formation and Cell Migration Journal of Cell Science. Jun, 2007 | Pubmed ID: 17504809 Increased Fibroblast Growth Factor-inducible 14 Expression Levels Promote Glioma Cell Invasion Via Rac1 and Nuclear Factor-kappaB and Correlate with Poor Patient Outcome Cancer Research. Oct, 2006 | Pubmed ID: 17018610 Molecular Pathways Triggering Glioma Cell Invasion Expert Review of Molecular Diagnostics. Jul, 2006 | Pubmed ID: 16824034 Cell Migration and Invasion Assays Methods (San Diego, Calif.). Oct, 2005 | Pubmed ID: 16288884 Roles of the Rac1 and Rac3 GTPases in Human Tumor Cell Invasion Oncogene. Nov, 2005 | Pubmed ID: 16027728 Role of Rho Family GTPases in CCR1- and CCR5-induced Actin Reorganization in Macrophages Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15882964 Rho GTPase-dependent Signaling is Required for Macrophage Migration Inhibitory Factor-mediated Expression of Cyclin D1 The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15840582 Role of NF-kappaB Signaling in Hepatocyte Growth Factor/scatter Factor-mediated Cell Protection Oncogene. Mar, 2005 | Pubmed ID: 15688034 Molecular Mechanisms of Invadopodium Formation: the Role of the N-WASP-Arp2/3 Complex Pathway and Cofilin The Journal of Cell Biology. Jan, 2005 | Pubmed ID: 15684033 Role of Synaptojanin 2 in Glioma Cell Migration and Invasion Cancer Research. Nov, 2004 | Pubmed ID: 15548694 Regulation of Anoikis by Cdc42 and Rac1 Experimental Cell Research. May, 2004 | Pubmed ID: 15093747 Molecular Basis for Rho GTPase Signaling Specificity Breast Cancer Research and Treatment. Mar, 2004 | Pubmed ID: 14999155 Modulation of Rac Localization and Function by Dynamin Molecular Biology of the Cell. Jan, 2004 | Pubmed ID: 14617821 Regulation of Migration of Primary Prostate Epithelial Cells by Secreted Factors from Prostate Stromal Cells Experimental Cell Research. Aug, 2003 | Pubmed ID: 12915116 Cyclin D1 Governs Adhesion and Motility of Macrophages Molecular Biology of the Cell. May, 2003 | Pubmed ID: 12802071 Control of Vesicular Trafficking by Rho GTPases Current Biology : CB. May, 2003 | Pubmed ID: 12747855 Synaptojanin 2 Functions at an Early Step of Clathrin-mediated Endocytosis Current Biology : CB. Apr, 2003 | Pubmed ID: 12699622 Cell Motility and Invasion Assays Methods in Molecular Biology (Clifton, N.J.). 2002 | Pubmed ID: 12094581 Role of Rho Family GTPases in Epithelial Morphogenesis Genes & Development. May, 2002 | Pubmed ID: 12000787 Regulation of Microtubule Stability and Mitotic Progression by Survivin Cancer Research. May, 2002 | Pubmed ID: 11980633 Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion Salvatore Coniglio1, Ian Miller2, Marc Symons3, Jeffrey E. Segall4 1New Jersey Center for Science, Technology and Mathematics, Kean University, 2Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 3The Feinstein Institute for Medical Research at North Shore-LIJ, 4Department of Anatomy and Structural Biology, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine JoVE 53990 Cancer Research
Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion Salvatore Coniglio1, Ian Miller2, Marc Symons3, Jeffrey E. Segall4 1New Jersey Center for Science, Technology and Mathematics, Kean University, 2Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 3The Feinstein Institute for Medical Research at North Shore-LIJ, 4Department of Anatomy and Structural Biology, Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine JoVE 53990 Cancer Research
