Martial Ruat CNRS, Université Paris Sud, UMR 9197, Neuroscience Paris-Saclay Institute, Molecules Circuits Department Biography Publications Institution JoVE Articles Martial Ruat has not added a biography. If you are Martial Ruat and would like to personalize this page please email our Author Liaison for assistance. Publications MRT-92 Inhibits Hedgehog Signaling by Blocking Overlapping Binding Sites in the Transmembrane Domain of the Smoothened Receptor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2015 | Pubmed ID: 25636740 Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions Stem Cell Reports. Aug, 2014 | Pubmed ID: 25254344 [Symmetric or Asymmetric Division: Sonic Hedgehog Controls the Fate of Neural Stem Cells] Médecine Sciences : M/S. Jun-Jul, 2014 | Pubmed ID: 25014467 Targeting of Smoothened for Therapeutic Gain Trends in Pharmacological Sciences. May, 2014 | Pubmed ID: 24703627 [Structure of the Smoothened Receptor] Médecine Sciences : M/S. Oct, 2013 | Pubmed ID: 24148123 Hedgehog-dependent Regulation of Angiogenesis and Myogenesis is Impaired in Aged Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2013 | Pubmed ID: 24135022 Roles of the Calcium Sensing Receptor in the Central Nervous System Best Practice & Research. Clinical Endocrinology & Metabolism. Jun, 2013 | Pubmed ID: 23856270 Investigation of the Proteolipid Protein Promoter Activity During Demyelination and Repair Differentiation; Research in Biological Diversity. Apr-Jun, 2013 | Pubmed ID: 23827460 The Choline Transporter-like Family SLC44: Properties and Roles in Human Diseases Molecular Aspects of Medicine. Apr-Jun, 2013 | Pubmed ID: 23506897 Discovery, Molecular and Pharmacological Characterization of GSA-10, a Novel Small-molecule Positive Modulator of Smoothened Molecular Pharmacology. May, 2013 | Pubmed ID: 23448715 Sonic Hedgehog Signaling is a Positive Oligodendrocyte Regulator During Demyelination The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23365216 Desert Hedgehog Promotes Ischemia-induced Angiogenesis by Ensuring Peripheral Nerve Survival Circulation Research. Mar, 2013 | Pubmed ID: 23343527 PTH-independent Regulation of Blood Calcium Concentration by the Calcium-sensing Receptor The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22886306 Inhibition of Hedgehog Signalling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis Annals of the Rheumatic Diseases. May, 2012 | Pubmed ID: 22402139 Hedgehog Signaling Controls Fibroblast Activation and Tissue Fibrosis in Systemic Sclerosis Arthritis and Rheumatism. Aug, 2012 | Pubmed ID: 22354771 Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity Journal of Medicinal Chemistry. Feb, 2012 | Pubmed ID: 22268551 Hedgehog Trafficking, Cilia and Brain Functions Differentiation; Research in Biological Diversity. Feb, 2012 | Pubmed ID: 22169886 [Shh Signal and Its Functional Roles in Normal and Diseased Brain] Médecine Sciences : M/S. Nov, 2011 | Pubmed ID: 22130025 An Inhibitory Effect of Extracellular Ca2+ on Ca2+-dependent Exocytosis PloS One. 2011 | Pubmed ID: 22028769 The Hedgehog Receptor Patched is Involved in Cholesterol Transport PloS One. 2011 | Pubmed ID: 21931618 Synthesis and Biological Evaluation of Desmethylveramiline, a Micromolar Hedgehog Inhibitor Bioorganic & Medicinal Chemistry Letters. Jun, 2011 | Pubmed ID: 21592788 Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antagonist Molecular Pharmacology. Mar, 2011 | Pubmed ID: 21177415 Design and Synthesis of Cyclic Sulfonamides and Sulfamates As New Calcium Sensing Receptor Agonists Bioorganic & Medicinal Chemistry Letters. Dec, 2010 | Pubmed ID: 21041081 Virtual Screening-based Discovery and Mechanistic Characterization of the Acylthiourea MRT-10 Family As Smoothened Antagonists Molecular Pharmacology. Oct, 2010 | Pubmed ID: 20664000 Sonic Hedgehog Signaling in the Mammalian Brain Journal of Neurochemistry. May, 2010 | Pubmed ID: 20218977 Presynaptic External Calcium Signaling Involves the Calcium-sensing Receptor in Neocortical Nerve Terminals PloS One. 2010 | Pubmed ID: 20052292 Calcium Sensing Receptor-dependent and Receptor-independent Activation of Osteoblast Replication and Survival by Strontium Ranelate Journal of Cellular and Molecular Medicine. Aug, 2009 | Pubmed ID: 20141614 Molecular Determinants of Non-competitive Antagonist Binding to the Mouse GPRC6A Receptor Cell Calcium. Nov-Dec, 2009 | Pubmed ID: 19836834 Functional Studies of Membrane-bound and Purified Human Hedgehog Receptor Patched Expressed in Yeast Biochimica Et Biophysica Acta. Sep, 2009 | Pubmed ID: 19463780 Chemoattractive Activity of Sonic Hedgehog in the Adult Subventricular Zone Modulates the Number of Neural Precursors Reaching the Olfactory Bulb Stem Cells (Dayton, Ohio). Sep, 2008 | Pubmed ID: 18617686 Evidence for the Presence of GPRC6A Receptors in Rat Mesenteric Arteries Cell Calcium. Aug, 2008 | Pubmed ID: 18221783 Oligodendrocyte Ablation Affects the Coordinated Interaction Between Granule and Purkinje Neurons During Cerebellum Development Experimental Cell Research. Aug, 2007 | Pubmed ID: 17544395 Distribution of Smoothened at Hippocampal Mossy Fiber Synapses Neuroreport. Mar, 2007 | Pubmed ID: 17435610 Identification and Characterization of Hedgehog Modulator Properties After Functional Coupling of Smoothened to G15 Biochemical and Biophysical Research Communications. Oct, 2006 | Pubmed ID: 16945339 N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) As a New Calcium Sensing Receptor Ligand Demonstrating Potent Calcilytic Activity Journal of Medicinal Chemistry. Aug, 2006 | Pubmed ID: 16913701 Increase of Proliferating Oligodendroglial Progenitors in the Adult Mouse Brain Upon Sonic Hedgehog Delivery in the Lateral Ventricle Journal of Neurochemistry. Jul, 2006 | Pubmed ID: 16805844 Transfer of Differentiation Signal by Membrane Microvesicles Harboring Hedgehog Morphogens Blood. Nov, 2006 | Pubmed ID: 16778137 Analysis of Hedgehog Interacting Protein in the Brain and Its Expression in Nitric Oxide Synthase-positive Cells Neuroreport. Nov, 2005 | Pubmed ID: 16272887 Delineating a Ca2+ Binding Pocket Within the Venus Flytrap Module of the Human Calcium-sensing Receptor The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16147994 Calindol, a Positive Allosteric Modulator of the Human Ca(2+) Receptor, Activates an Extracellular Ligand-binding Domain-deleted Rhodopsin-like Seven-transmembrane Structure in the Absence of Ca(2+) The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16135510 Sonic Hedgehog Signalling in Neurons of Adult Ventrolateral Nucleus Tractus Solitarius The European Journal of Neuroscience. Jul, 2005 | Pubmed ID: 16045492 Evidence in Favor of a Calcium-sensing Receptor in Arterial Endothelial Cells: Studies with Calindol and Calhex 231 Circulation Research. Aug, 2005 | Pubmed ID: 16037572 [New Insights into the Pharmacology of the Extracellular Calcium Sensing Receptor] Médecine Sciences : M/S. Nov, 2004 | Pubmed ID: 15525493 In Vitro Effects of Strontium Ranelate on the Extracellular Calcium-sensing Receptor Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15451421 N(1)-Arylsulfonyl-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes: a New Class of Calcilytic Agents Acting at the Calcium-sensing Receptor Chembiochem : a European Journal of Chemical Biology. Aug, 2004 | Pubmed ID: 15300839 Functional Characterization of Sonic Hedgehog Mutations Associated with Holoprosencephaly The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15292211 Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients Cancer Research. May, 2004 | Pubmed ID: 15150112 N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and Conformationally Restrained Indole Analogues: Development of Calindol As a New Calcimimetic Acting at the Calcium Sensing Receptor Bioorganic & Medicinal Chemistry Letters. Jun, 2004 | Pubmed ID: 15149704 Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact Within Overlapping but Not Identical Binding Sites in the Transmembrane Domain The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14976203 [Pharmacology of the Extracellular Calcium Ion Receptor] Thérapie. Sep-Oct, 2003 | Pubmed ID: 14682186 Modeling and Mutagenesis of the Binding Site of Calhex 231, a Novel Negative Allosteric Modulator of the Extracellular Ca(2+)-sensing Receptor The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14506236 Developmental Expression of the Cellular Prion Protein in Elongating Axons The European Journal of Neuroscience. Apr, 2002 | Pubmed ID: 11982627 Sonic Hedgehog Signalling in the Developing and Adult Brain Journal of Physiology, Paris. Jan-Mar, 2002 | Pubmed ID: 11755778 Cell Sortering av Neural stilk og stamceller fra Adult Mouse subventricular Zone og Live-avbildning av deres Cell Cycle Dynamics Mathieu Daynac*1,2,3,4,5, Lise Morizur*1,2,3,4, Thierry Kortulewski1,2,3,4, Laurent R. Gauthier1,2,3,4, Martial Ruat5, Marc-André Mouthon1,2,3,4, François D. Boussin1,2,3,4 1CEA DSV iRCM SCSR, Laboratoire de Radiopathologie, UMR 967, 2INSERM, UMR 967, 3Université Paris Diderot, Sorbonne Paris Cité, UMR 967, 4Université Paris Sud, UMR 967, 5CNRS, Université Paris Sud, UMR 9197, Neuroscience Paris-Saclay Institute, Molecules Circuits Department Neuroscience
Cell Sortering av Neural stilk og stamceller fra Adult Mouse subventricular Zone og Live-avbildning av deres Cell Cycle Dynamics Mathieu Daynac*1,2,3,4,5, Lise Morizur*1,2,3,4, Thierry Kortulewski1,2,3,4, Laurent R. Gauthier1,2,3,4, Martial Ruat5, Marc-André Mouthon1,2,3,4, François D. Boussin1,2,3,4 1CEA DSV iRCM SCSR, Laboratoire de Radiopathologie, UMR 967, 2INSERM, UMR 967, 3Université Paris Diderot, Sorbonne Paris Cité, UMR 967, 4Université Paris Sud, UMR 967, 5CNRS, Université Paris Sud, UMR 9197, Neuroscience Paris-Saclay Institute, Molecules Circuits Department Neuroscience
