Martin McMahon

Publications

• BRAFV600E Cooperates with PI3'-Kinase Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation
  Molecular Cancer Research : MCR. Jan, 2014  |   Pubmed ID: 24425783
• Abnormal Ras Signaling in Costello Syndrome (CS) Negatively Regulates Enamel Formation
  Human Molecular Genetics. Feb, 2014  |   Pubmed ID: 24057668
• Differential AKT Dependency Displayed by Mouse Models of BRAFV600E-initiated Melanoma
  The Journal of Clinical Investigation. Dec, 2013  |   Pubmed ID: 24200692
• Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-lineage Cells Resistant to PLX4720
  Molecular Cancer Research : MCR. Dec, 2013  |   Pubmed ID: 24152792
• Phenformin Enhances the Therapeutic Benefit of BRAF(V600E) Inhibition in Melanoma
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013  |   Pubmed ID: 24145418
• Mutationally Activated PIK3CA(H1047R) Cooperates with BRAF(V600E) to Promote Lung Cancer Progression
  Cancer Research. Nov, 2013  |   Pubmed ID: 24019382
• Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-driven Lung Tumors
  Cancer Discovery. Nov, 2013  |   Pubmed ID: 23965987
• Modelling Vemurafenib Resistance in Melanoma Reveals a Strategy to Forestall Drug Resistance
  Nature. Feb, 2013  |   Pubmed ID: 23302800
• Elucidating Distinct Roles for NF1 in Melanomagenesis
  Cancer Discovery. Mar, 2013  |   Pubmed ID: 23171796
• Oncogene-dependent Control of MiRNA Biogenesis and Metastatic Progression in a Model of Undifferentiated Pleomorphic Sarcoma
  The Journal of Pathology. Jan, 2013  |   Pubmed ID: 22951975
• An Ultraviolet-radiation-independent Pathway to Melanoma Carcinogenesis in the Red Hair/fair Skin Background
  Nature. Nov, 2012  |   Pubmed ID: 23123854
• The Intermediate-activity (L597V)BRAF Mutant Acts As an Epistatic Modifier of Oncogenic RAS by Enhancing Signaling Through the RAF/MEK/ERK Pathway
  Genes & Development. Sep, 2012  |   Pubmed ID: 22892241
• B-Raf Activation Cooperates with PTEN Loss to Drive C-Myc Expression in Advanced Prostate Cancer
  Cancer Research. Sep, 2012  |   Pubmed ID: 22836754
• Analysis of MRNA Profiles After MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity
  Molecular Cancer Research : MCR. Dec, 2012  |   Pubmed ID: 22833572
• Regulated Temporal-spatial Astrocyte Precursor Cell Proliferation Involves BRAF Signalling in Mammalian Spinal Cord
  Development (Cambridge, England). Jul, 2012  |   Pubmed ID: 22675209
• A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
  Cancer Discovery. Aug, 2012  |   Pubmed ID: 22628411
• Cooperative Interactions of BRAFV600E Kinase and CDKN2A Locus Deficiency in Pediatric Malignant Astrocytoma As a Basis for Rational Therapy
  Proceedings of the National Academy of Sciences of the United States of America. May, 2012  |   Pubmed ID: 22586120
• Abrogation of BRAFV600E-induced Senescence by PI3K Pathway Activation Contributes to Melanomagenesis
  Genes & Development. May, 2012  |   Pubmed ID: 22549727
• E-cadherin Regulates the Behavior and Fate of Epithelial Stem Cells and Their Progeny in the Mouse Incisor
  Developmental Biology. Jun, 2012  |   Pubmed ID: 22537490
• MEK1/2 Inhibition Elicits Regression of Autochthonous Lung Tumors Induced by KRASG12D or BRAFV600E
  Cancer Research. Jun, 2012  |   Pubmed ID: 22511580
• β-catenin Signaling Controls Metastasis in Braf-activated Pten-deficient Melanomas
  Cancer Cell. Dec, 2011  |   Pubmed ID: 22172720
• Control of Mitotic Spindle Angle by the RAS-regulated ERK1/2 Pathway Determines Lung Tube Shape
  Science (New York, N.Y.). Jul, 2011  |   Pubmed ID: 21764747
• Mutationally Activated BRAF(V600E) Elicits Papillary Thyroid Cancer in the Adult Mouse
  Cancer Research. Jun, 2011  |   Pubmed ID: 21512141
• Costello and Cardio-facio-cutaneous Syndromes: Moving Toward Clinical Trials in RASopathies
  American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. May, 2011  |   Pubmed ID: 21495172
• Parsing out the Complexity of RAF Inhibitor Resistance
  Pigment Cell & Melanoma Research. Apr, 2011  |   Pubmed ID: 21392366
• RAF Translocations Expand Cancer Targets
  Nature Medicine. Jul, 2010  |   Pubmed ID: 20613748
• Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver
  Science Translational Medicine. Jan, 2010  |   Pubmed ID: 20371474
• Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell
  Cancer Research. Jan, 2010  |   Pubmed ID: 20048081
• Proceedings from the 2009 Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back
  American Journal of Medical Genetics. Part A. Jan, 2010  |   Pubmed ID: 20014119
• Down-regulation of Cdx2 in Colorectal Carcinoma Cells by the Raf-MEK-ERK 1/2 Pathway
  Cellular Signalling. Dec, 2009  |   Pubmed ID: 19686845
• Meeting Report: Consensus from the First and Second Global Workshops in Melanoma November 19-20, 2008
  Pigment Cell & Melanoma Research. Oct, 2009  |   Pubmed ID: 19659612
• Braf(V600E) Cooperates with Pten Loss to Induce Metastatic Melanoma
  Nature Genetics. May, 2009  |   Pubmed ID: 19282848
• Oncogenic BRAF(V600E) Inhibits BIM Expression to Promote Melanoma Cell Survival
  Pigment Cell & Melanoma Research. Oct, 2008  |   Pubmed ID: 18715233
• Meeting Report: Fourth International Congress of the Society for Melanoma Research
  Pigment Cell & Melanoma Research. Feb, 2008  |   Pubmed ID: 18353140
• A Model of Intussusceptive Angiogenesis
  Novartis Foundation Symposium. 2007  |   Pubmed ID: 18300412
• A New Mouse Model to Explore the Initiation, Progression, and Therapy of BRAFV600E-induced Lung Tumors
  Genes & Development. Feb, 2007  |   Pubmed ID: 17299132
• Diverse Toll-like Receptors Utilize Tpl2 to Activate Extracellular Signal-regulated Kinase (ERK) in Hemopoietic Cells
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006  |   Pubmed ID: 16484370
• Constitutive Activation of Akt by Flt3 Internal Tandem Duplications is Necessary for Increased Survival, Proliferation, and Myeloid Transformation
  Cancer Research. Nov, 2005  |   Pubmed ID: 16266983
• The Epidermal Growth Factor Receptor Gene Family As a Target for Therapeutic Intervention in Numerous Cancers: What's Genetics Got to Do with It?
  Expert Opinion on Therapeutic Targets. Oct, 2005  |   Pubmed ID: 16185155
• Pharmacologic Inhibition of RAF-->MEK-->ERK Signaling Elicits Pancreatic Cancer Cell Cycle Arrest Through Induced Expression of P27Kip1
  Cancer Research. Jun, 2005  |   Pubmed ID: 15930308
• Analysis of Genomic DNA Alterations and MRNA Expression Patterns in a Panel of Human Pancreatic Cancer Cell Lines
  Genes, Chromosomes & Cancer. Sep, 2005  |   Pubmed ID: 15929091
• Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines
  Cell Cycle (Georgetown, Tex.). Jun, 2005  |   Pubmed ID: 15917660
• Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor
  Molecular and Cellular Biology. Jan, 2005  |   Pubmed ID: 15601844
• Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT
  Molecular and Cellular Biology. Dec, 2004  |   Pubmed ID: 15572689
• Effects of a Conditionally Active V-ErbB and an EGF-R Inhibitor on Transformation of NIH-3T3 Cells and Abrogation of Cytokine Dependency of Hematopoietic Cells
  Oncogene. Oct, 2004  |   Pubmed ID: 15361836
• Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15128735
• Inactivation of Icmt Inhibits Transformation by Oncogenic K-Ras and B-Raf
  The Journal of Clinical Investigation. Feb, 2004  |   Pubmed ID: 14966563
• DeltaRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry
  Molecular and Cellular Biology. Dec, 2003  |   Pubmed ID: 14645540
• Hedgehog is an Early and Late Mediator of Pancreatic Cancer Tumorigenesis
  Nature. Oct, 2003  |   Pubmed ID: 14520413
• Ras-induced Serine Phosphorylation of the Focal Adhesion Protein Paxillin is Mediated by the Raf-->MEK-->ERK Pathway
  Experimental Cell Research. Jul, 2003  |   Pubmed ID: 12837288
• Inhibition of the Raf/MEK/ERK Pathway Up-regulates Expression of the Coxsackievirus and Adenovirus Receptor in Cancer Cells
  Cancer Research. May, 2003  |   Pubmed ID: 12727824
• Effects of the RAF/MEK/ERK and PI3K/AKT Signal Transduction Pathways on the Abrogation of Cytokine-dependence and Prevention of Apoptosis in Hematopoietic Cells
  Oncogene. Apr, 2003  |   Pubmed ID: 12717425
• De Novo Infection and Serial Transmission of Kaposi's Sarcoma-associated Herpesvirus in Cultured Endothelial Cells
  Journal of Virology. Mar, 2002  |   Pubmed ID: 11836422
• Induction of Tubulogenesis in Telomerase-immortalized Human Microvascular Endothelial Cells by Glioblastoma Cells
  Experimental Cell Research. Feb, 2002  |   Pubmed ID: 11795943