Mauricio Rojas Center for Respiratory Health Emory University Biography Publications Institution JoVE Articles Mauricio Rojas has not added a biography. If you are Mauricio Rojas and would like to personalize this page please email our Author Liaison for assistance. Publications Circulating Endothelial Progenitor Cells Inversely Associate with Organ Dysfunction in Sepsis Intensive Care Medicine. Feb, 2012 | Pubmed ID: 22331369 Stable Extracellular RNA Fragments of Mycobacterium Tuberculosis Induce Early Apoptosis in Human Monocytes Via a Caspase-8 Dependent Mechanism PloS One. 2012 | Pubmed ID: 22253841 Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis American Journal of Respiratory Cell and Molecular Biology. Jan, 2012 | Pubmed ID: 22227563 T Cell Responses to DosR and Rpf Proteins in Actively and Latently Infected Individuals from Colombia Tuberculosis (Edinburgh, Scotland). Jan, 2012 | Pubmed ID: 22226907 Mitochondrial Oxidative Stress in Aortic Stiffening With Age: The Role of Smooth Muscle Cell Function Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011 | Pubmed ID: 22199367 Predisposition for Disrepair in the Aged Lung The American Journal of the Medical Sciences. Dec, 2011 | Pubmed ID: 22173045 Wnt1/βcatenin Injury Response Activates the Epicardium and Cardiac Fibroblasts to Promote Cardiac Repair The EMBO Journal. 2011 | Pubmed ID: 22085926 Stem Cells and Cell Therapies in Lung Biology and Lung Diseases Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653527 Increased Frequency and Cell Death of CD16+ Monocytes with Mycobacterium Tuberculosis Infection Tuberculosis (Edinburgh, Scotland). Sep, 2011 | Pubmed ID: 21621464 Fatty Acid Profile During the Differentiation and Infection with Mycobacterium Tuberculosis of Mononuclear Phagocytes of Patients with TB and Healthy Individuals Cellular Immunology. 2011 | Pubmed ID: 21571261 Mycobacterium Tuberculosis Alters the Differentiation of Monocytes into Macrophages in Vitro Cellular Immunology. 2011 | Pubmed ID: 21420074 Airway and Plasma Leptin and Adiponectin in Lean and Obese Asthmatics and Controls The Journal of Asthma : Official Journal of the Association for the Care of Asthma. Apr, 2011 | Pubmed ID: 21332421 Age and Smoke: a Risky Combination American Journal of Respiratory and Critical Care Medicine. Feb, 2011 | Pubmed ID: 21325078 Wnt1 is a Proangiogenic Molecule, Enhances Human Endothelial Progenitor Function, and Increases Blood Flow to Ischemic Limbs in a HGF-dependent Manner FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2011 | Pubmed ID: 21321190 The Pathology of Bleomycin-induced Fibrosis is Associated with Loss of Resident Lung Mesenchymal Stem Cells That Regulate Effector T-cell Proliferation Stem Cells (Dayton, Ohio). Apr, 2011 | Pubmed ID: 21312316 Atherosclerosis Development in SLE Patients is Not Determined by Monocytes Ability to Bind/endocytose Ox-LDL Autoimmunity. May, 2011 | Pubmed ID: 21231894 Attenuation of Early Airway Obstruction by Mesenchymal Stem Cells in a Murine Model of Heterotopic Tracheal Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2011 | Pubmed ID: 21093298 Dipyrimidine Amines: a Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity Journal of Medicinal Chemistry. Dec, 2010 | Pubmed ID: 21105715 Effect of Bone Marrow-derived Mesenchymal Stem Cells on Endotoxin-induced Oxidation of Plasma Cysteine and Glutathione in Mice Stem Cells International. 2010 | Pubmed ID: 21048855 Aging and Interstitial Lung Diseases: Unraveling an Old Forgotten Player in the Pathogenesis of Lung Fibrosis Seminars in Respiratory and Critical Care Medicine. Oct, 2010 | Pubmed ID: 20941661 Characterization of CD4 and CD8 T Cells Producing IFN-γ in Human Latent and Active Tuberculosis Tuberculosis (Edinburgh, Scotland). Nov, 2010 | Pubmed ID: 20933471 [Alterations in Recruitment and Activation of Rab Proteins During Mycobacterial Infection] Biomédica : Revista Del Instituto Nacional De Salud. Apr-Jun, 2010 | Pubmed ID: 20890576 Monocyte Activation by Apoptotic Cells Removal in Systemic Lupus Erythematosus Patients Cellular Immunology. 2010 | Pubmed ID: 20863485 Dual Targeting of CCR2 and CX3CR1 in an Arterial Injury Model of Vascular Inflammation Thrombosis Journal. 2010 | Pubmed ID: 20836883 Protease-activated Receptor 2 Deficiency Reduces Cardiac Ischemia/reperfusion Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2010 | Pubmed ID: 20724699 Obstructive Apneas Induce Early Activation of Mesenchymal Stem Cells and Enhancement of Endothelial Wound Healing Respiratory Research. 2010 | Pubmed ID: 20604943 Regulatory T Cell Frequency and Modulation of IFN-gamma and IL-17 in Active and Latent Tuberculosis Tuberculosis (Edinburgh, Scotland). Jul, 2010 | Pubmed ID: 20594914 Inhibition of NF-kappaB Signaling Reduces Virus Load and Gammaherpesvirus-induced Pulmonary Fibrosis The American Journal of Pathology. Aug, 2010 | Pubmed ID: 20566741 Human Monocyte Differentiation Stage Affects Response to Arachidonic Acid Cellular Immunology. 2010 | Pubmed ID: 20537616 A Senescence Accelerated Mouse Model to Study Aging in the Larynx Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Jun, 2010 | Pubmed ID: 20493362 Slow-release Nanoparticle-encapsulated Delivery System for Laryngeal Injection The Laryngoscope. May, 2010 | Pubmed ID: 20422696 Nox Activator 1: a Potential Target for Modulation of Vascular Reactive Oxygen Species in Atherosclerotic Arteries Circulation. Feb, 2010 | Pubmed ID: 20083677 Role of TLR2- and TLR4-mediated Signaling in Mycobacterium Tuberculosis-induced Macrophage Death Cellular Immunology. 2010 | Pubmed ID: 19919859 Twist: a Regulator of Epithelial-mesenchymal Transition in Lung Fibrosis PloS One. 2009 | Pubmed ID: 19851501 Reduced EGFR Causes Abnormal Valvular Differentiation Leading to Calcific Aortic Stenosis and Left Ventricular Hypertrophy in C57BL/6J but Not 129S1/SvImJ Mice American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2009 | Pubmed ID: 19448146 Transient Expression of FRNK Reveals Stage-specific Requirement for Focal Adhesion Kinase Activity in Cardiac Growth Circulation Research. May, 2009 | Pubmed ID: 19372463 Use of Senescence-accelerated Mouse Model in Bleomycin-induced Lung Injury Suggests That Bone Marrow-derived Cells Can Alter the Outcome of Lung Injury in Aged Mice The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jul, 2009 | Pubmed ID: 19359440 Cysteine Redox Potential Determines Pro-inflammatory IL-1beta Levels PloS One. 2009 | Pubmed ID: 19325908 Muscle Ring Finger 1 Mediates Cardiac Atrophy in Vivo American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2009 | Pubmed ID: 19168726 Regression of Pressure-induced Left Ventricular Hypertrophy is Characterized by a Distinct Gene Expression Profile The Journal of Thoracic and Cardiovascular Surgery. Jan, 2009 | Pubmed ID: 19154930 FAK Regulates Cardiomyocyte Survival Following Ischemia/reperfusion Journal of Molecular and Cellular Cardiology. Feb, 2009 | Pubmed ID: 19028502 Oxidation of Extracellular Cysteine/cystine Redox State in Bleomycin-induced Lung Fibrosis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2009 | Pubmed ID: 18931052 Oxidation of Plasma Cysteine/cystine Redox State in Endotoxin-induced Lung Injury American Journal of Respiratory Cell and Molecular Biology. Jan, 2009 | Pubmed ID: 18664641 Activation of Tissue Remodeling Precedes Obliterative Bronchiolitis in Lung Transplant Recipients Biomarker Insights. 2008 | Pubmed ID: 19578518 Attenuation of Obliterative Bronchiolitis by a CXCR4 Antagonist in the Murine Heterotopic Tracheal Transplant Model The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Dec, 2008 | Pubmed ID: 19059110 FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2008 | Pubmed ID: 18787183 Aging and Lung Injury Repair: a Role for Bone Marrow Derived Mesenchymal Stem Cells Journal of Cellular Biochemistry. Oct, 2008 | Pubmed ID: 18759327 Discordant On/off Switching of Gene Expression in Myocytes During Cardiac Hypertrophy in Vivo Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18755891 Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure Circulation Research. Sep, 2008 | Pubmed ID: 18703779 Flagellin Treatment Protects Against Chemicals, Bacteria, Viruses, and Radiation Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18523294 Monitoring of Endothelial Dysfunction in Critically Ill Patients: the Role of Endothelial Progenitor Cells Current Opinion in Critical Care. Jun, 2008 | Pubmed ID: 18467899 Anti-inflammatory Effects of Mesenchymal Stem Cells: Novel Concept for Future Therapies Expert Opinion on Biological Therapy. May, 2008 | Pubmed ID: 18407762 Targeted Deletion of Dicer in the Heart Leads to Dilated Cardiomyopathy and Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18256189 Activation of Apoptosis, but Not Necrosis, During Mycobacterium Tuberculosis Infection Correlated with Decreased Bacterial Growth: Role of TNF-alpha, IL-10, Caspases and Phospholipase A2 Cellular Immunology. Oct, 2007 | Pubmed ID: 18160064 Progression of Pulmonary Tuberculosis and Efficiency of Bacillus Calmette-Guérin Vaccination Are Genetically Controlled Via a Common Sst1-mediated Mechanism of Innate Immunity Journal of Immunology (Baltimore, Md. : 1950). Nov, 2007 | Pubmed ID: 17982083 The Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligand Rosiglitazone Modulates Bronchoalveolar Lavage Levels of Leptin, Adiponectin, and Inflammatory Cytokines in Lean and Obese Mice Lung. Dec, 2007 | Pubmed ID: 17909895 Age-related Changes in the Murine Larynx: Initial Validation of a Mouse Model The Annals of Otology, Rhinology, and Laryngology. Aug, 2007 | Pubmed ID: 17847730 Atherosclerosis is Attenuated by Limiting Superoxide Generation in Both Macrophages and Vessel Wall Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2007 | Pubmed ID: 17823367 Abnormal Humoral Immune Response to Influenza Vaccination in Pediatric Type-1 Human Immunodeficiency Virus Infected Patients Receiving Highly Active Antiretroviral Therapy Memórias Do Instituto Oswaldo Cruz. Jun, 2007 | Pubmed ID: 17612772 Characterization of a Model to Independently Study Regression of Ventricular Hypertrophy The Journal of Surgical Research. Oct, 2007 | Pubmed ID: 17574596 Leukocyte Antigen-related Deficiency Enhances Insulin-like Growth Factor-1 Signaling in Vascular Smooth Muscle Cells and Promotes Neointima Formation in Response to Vascular Injury The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17500057 Expression of MicroRNAs is Dynamically Regulated During Cardiomyocyte Hypertrophy Journal of Molecular and Cellular Cardiology. Jun, 2007 | Pubmed ID: 17498736 Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and Fibrosis American Journal of Respiratory Cell and Molecular Biology. Sep, 2007 | Pubmed ID: 17463394 Body Mass Index is Associated with Reduced Exhaled Nitric Oxide and Higher Exhaled 8-isoprostanes in Asthmatics Respiratory Research. 2007 | Pubmed ID: 17437645 Prevention of Endotoxin-induced Systemic Response by Bone Marrow-derived Mesenchymal Stem Cells in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2007 | Pubmed ID: 17416739 Control of Virus Reactivation Arrests Pulmonary Herpesvirus-induced Fibrosis in IFN-gamma Receptor-deficient Mice American Journal of Respiratory and Critical Care Medicine. Jun, 2007 | Pubmed ID: 17363768 Cardiac Response to Pressure Overload in 129S1/SvImJ and C57BL/6J Mice: Temporal- and Background-dependent Development of Concentric Left Ventricular Hypertrophy American Journal of Physiology. Heart and Circulatory Physiology. May, 2007 | Pubmed ID: 17172276 Src Family Kinases Mediate Neutrophil Adhesion to Adherent Platelets Blood. Mar, 2007 | Pubmed ID: 17095622 Selective Ablation of Matrix Metalloproteinase-2 Exacerbates Experimental Colitis: Contrasting Role of Gelatinases in the Pathogenesis of Colitis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16951375 Myocyte-restricted Focal Adhesion Kinase Deletion Attenuates Pressure Overload-induced Hypertrophy Circulation Research. Sep, 2006 | Pubmed ID: 16902179 Functional and Phenotypic Changes in Monocytes from Patients with Tuberculosis Are Reversed with Treatment Microbes and Infection / Institut Pasteur. Aug, 2006 | Pubmed ID: 16872859 CX3CR1 Deficiency Confers Protection from Intimal Hyperplasia After Arterial Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2006 | Pubmed ID: 16809547 Activation of Alveolar Macrophages Via the Alternative Pathway in Herpesvirus-induced Lung Fibrosis American Journal of Respiratory Cell and Molecular Biology. Oct, 2006 | Pubmed ID: 16709958 Increased Bleomycin-induced Lung Injury in Mice Deficient in the Transcription Factor T-bet American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2006 | Pubmed ID: 16648243 Thrombin and NAD(P)H Oxidase-mediated Regulation of CD44 and BMP4-Id Pathway in VSMC, Restenosis, and Atherosclerosis Circulation Research. May, 2006 | Pubmed ID: 16601225 Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-derived MMP Gastroenterology. Dec, 2005 | Pubmed ID: 16344067 Increased Circulating Endothelial Progenitor Cells Are Associated with Survival in Acute Lung Injury American Journal of Respiratory and Critical Care Medicine. Oct, 2005 | Pubmed ID: 15976374 Prevention of NF-kappaB Activation in Vivo by a Cell-permeable NF-kappaB Inhibitor Peptide American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2005 | Pubmed ID: 15951331 Bone Marrow-derived Mesenchymal Stem Cells in Repair of the Injured Lung American Journal of Respiratory Cell and Molecular Biology. Aug, 2005 | Pubmed ID: 15891110 Ipr1 Gene Mediates Innate Immunity to Tuberculosis Nature. Apr, 2005 | Pubmed ID: 15815631 Lung Infection with Gamma-herpesvirus Induces Progressive Pulmonary Fibrosis in Th2-biased Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2005 | Pubmed ID: 15734789 Endotoxin-induced Lung Injury in Mice: Structural, Functional, and Biochemical Responses American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2005 | Pubmed ID: 15475380 The Host Resistance Locus Sst1 Controls Innate Immunity to Listeria Monocytogenes Infection in Immunodeficient Mice Journal of Immunology (Baltimore, Md. : 1950). Oct, 2004 | Pubmed ID: 15470055 Differential Induction of Apoptosis and Necrosis in Monocytes from Patients with Tuberculosis and Healthy Control Subjects The Journal of Infectious Diseases. Jun, 2004 | Pubmed ID: 15143481 Structure and Function of CD72 in the Non-obese Diabetic (NOD) Mouse Autoimmunity. Jun, 2003 | Pubmed ID: 14563017 Modulation of Macrophage Apoptosis by Antimycobacterial Therapy: Physiological Role of Apoptosis in the Control of Mycobacterium Tuberculosis Toxicology and Applied Pharmacology. Jul, 2003 | Pubmed ID: 12878041 Activation of JAK2/STAT1-alpha-dependent Signaling Events During Mycobacterium Tuberculosis-induced Macrophage Apoptosis Cellular Immunology. May-Jun, 2002 | Pubmed ID: 12426001 Mycobacterial Lipoarabinomannans: Modulators of Dendritic Cell Function and the Apoptotic Response Microbes and Infection / Institut Pasteur. Jul, 2002 | Pubmed ID: 12106787 Differential Modulation of Apoptosis and Necrosis by Antioxidants in Immunosuppressed Human Lymphocytes Toxicology and Applied Pharmacology. Apr, 2002 | Pubmed ID: 11969373 Direct Tracheal Instillation of Solutes into Mouse Lung My N. Helms1,2, Edilson Torres-Gonzalez2,3, Preston Goodson1, Mauricio Rojas2,3 1Department of Physiology, Emory University, 2Center for Respiratory Health, Emory University, 3Department of Medicine, Emory University JoVE 1941 Biology
Direct Tracheal Instillation of Solutes into Mouse Lung My N. Helms1,2, Edilson Torres-Gonzalez2,3, Preston Goodson1, Mauricio Rojas2,3 1Department of Physiology, Emory University, 2Center for Respiratory Health, Emory University, 3Department of Medicine, Emory University JoVE 1941 Biology