Melanie H. Cobb

Publications

• WNK Pathways in Cancer Signaling Networks
  Cell Communication and Signaling : CCS. 11, 2018  |   Pubmed ID: 30390653
• Chromomycin A Potently Inhibits Glucose-stimulated Insulin Secretion from Pancreatic β Cells
  The Journal of General Physiology. Dec, 2018  |   Pubmed ID: 30352794
• Pulling a MAST1 on Cisplatin Resistance
  Cancer Cell. 08, 2018  |   Pubmed ID: 30107173
• OSR1 Regulates a Subset of Inward Rectifier Potassium Channels Via a Binding Motif Variant
  Proceedings of the National Academy of Sciences of the United States of America. 04, 2018  |   Pubmed ID: 29581290
• Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization
  Developmental Cell. 03, 2018  |   Pubmed ID: 29503158
• The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors
  Translational Oncology. Apr, 2018  |   Pubmed ID: 29413762
• Differential Abundance of CK1α Provides Selectivity for Pharmacological CK1α Activators to Target WNT-dependent Tumors
  Science Signaling. Jun, 2017  |   Pubmed ID: 28655862
• Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell
  Pharmacology & Therapeutics. Nov, 2017  |   Pubmed ID: 28527919
• WNK1 is an Unexpected Autophagy Inhibitor
  Autophagy. Feb, 2017  |   Pubmed ID: 28282258
• Sucralose Activates an ERK1/2-ribosomal Protein S6 Signaling Axis
  FEBS Open Bio. Feb, 2017  |   Pubmed ID: 28174684
• Chemoattractant Concentration-dependent Tuning of ERK Signaling Dynamics in Migrating Neutrophils
  Science Signaling. Dec, 2016  |   Pubmed ID: 27965424
• Multistep Regulation of Autophagy by WNK1
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2016  |   Pubmed ID: 27911840
• Insulin Promoter-driven Gaussia Luciferase-based Insulin Secretion Biosensor Assay for Discovery of β-cell Glucose-sensing Pathways
  ACS Sensors. Oct, 2016  |   Pubmed ID: 27819058
• Amino Acids Regulate MTORC1 by an Obligate Two-step Mechanism
  The Journal of Biological Chemistry. Oct, 2016  |   Pubmed ID: 27587390
• Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis Via Nonmuscle Myosin II
  Circulation Research. Sep, 2016  |   Pubmed ID: 27486147
• ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs
  Cell Reports. Aug, 2016  |   Pubmed ID: 27452466
• Hypertension: the Missing WNKs
  American Journal of Physiology. Renal Physiology. Jul, 2016  |   Pubmed ID: 27009339
• Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding
  Biochemistry. Mar, 2016  |   Pubmed ID: 26950759
• Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
  Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Apr, 2016  |   Pubmed ID: 26829312
• Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells
  ACS Chemical Biology. Apr, 2016  |   Pubmed ID: 26828310
• A Kinase Divided
  Cancer Cell. Aug, 2015  |   Pubmed ID: 26267529
• Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK
  Biochemistry. Aug, 2015  |   Pubmed ID: 26208601
• Differential Regulation of ERK1/2 and MTORC1 Through T1R1/T1R3 in MIN6 Cells
  Molecular Endocrinology (Baltimore, Md.). Aug, 2015  |   Pubmed ID: 26168033
• Actions of the Protein Kinase WNK1 on Endothelial Cells Are Differentially Mediated by Its Substrate Kinases OSR1 and SPAK
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014  |   Pubmed ID: 25362046
• ASCL1 is a Lineage Oncogene Providing Therapeutic Targets for High-grade Neuroendocrine Lung Cancers
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014  |   Pubmed ID: 25267614
• Menin Determines K-RAS Proliferative Outputs in Endocrine Cells
  The Journal of Clinical Investigation. Sep, 2014  |   Pubmed ID: 25133424
• ERK5 Signaling Gets XIAPed: a Role for Ubiquitin in the Disassembly of a MAPK Cascade
  The EMBO Journal. Aug, 2014  |   Pubmed ID: 25012518
• Ras Transformation Uncouples the Kinesin-coordinated Cellular Nutrient Response
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25002494
• Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation
  Science Signaling. May, 2014  |   Pubmed ID: 24803536
• G Protein-coupled Receptors and the Regulation of Autophagy
  Trends in Endocrinology and Metabolism: TEM. May, 2014  |   Pubmed ID: 24751357
• NeuroD1 Mediates Nicotine-induced Migration and Invasion Via Regulation of the Nicotinic Acetylcholine Receptor Subunits in a Subset of Neural and Neuroendocrine Carcinomas
  Molecular Biology of the Cell. Jun, 2014  |   Pubmed ID: 24719457
• Muscarinic Control of MIN6 Pancreatic β Cells is Enhanced by Impaired Amino Acid Signaling
  The Journal of Biological Chemistry. May, 2014  |   Pubmed ID: 24695728
• Regulation of OSR1 and the Sodium, Potassium, Two Chloride Cotransporter by Convergent Signals
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013  |   Pubmed ID: 24191005
• Off-target Effects of MEK Inhibitors
  Biochemistry. Aug, 2013  |   Pubmed ID: 23848362
• Minireview: Nutrient Sensing by G Protein-coupled Receptors
  Molecular Endocrinology (Baltimore, Md.). Aug, 2013  |   Pubmed ID: 23820899
• NeuroD1 Regulates Survival and Migration of Neuroendocrine Lung Carcinomas Via Signaling Molecules TrkB and NCAM
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013  |   Pubmed ID: 23553831
• Chromatin-tethered MAPKs
  Current Opinion in Cell Biology. Apr, 2013  |   Pubmed ID: 23434067
• Amino Acid Regulation of Autophagy Through the GPCR TAS1R1-TAS1R3
  Autophagy. Mar, 2013  |   Pubmed ID: 23222068
• Protein Kinase WNK3 Regulates the Neuronal Splicing Factor Fox-1
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23027929
• Interactions with WNK (with No Lysine) Family Members Regulate Oxidative Stress Response 1 and Ion Co-transporter Activity
  The Journal of Biological Chemistry. Nov, 2012  |   Pubmed ID: 22989884
• The G Protein-coupled Taste Receptor T1R1/T1R3 Regulates MTORC1 and Autophagy
  Molecular Cell. Sep, 2012  |   Pubmed ID: 22959271
• Signal Control Through Raf: in Sickness and in Health
  Cell Research. Jan, 2012  |   Pubmed ID: 22143568
• A Small Molecule Differentiation Inducer Increases Insulin Production by Pancreatic β Cells
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011  |   Pubmed ID: 22143803
• WNK1 is Required for Mitosis and Abscission
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21220314
• Exposing Contingency Plans for Kinase Networks
  Cell. Dec, 2010  |   Pubmed ID: 21145453
• Calcineurin Increases Glucose Activation of ERK1/2 by Reversing Negative Feedback
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2010  |   Pubmed ID: 21135229
• Reconstitution of the Nuclear Transport of the MAP Kinase ERK2
  Methods in Molecular Biology (Clifton, N.J.). 2010  |   Pubmed ID: 20811989
• Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members
  The Journal of Biological Chemistry. Aug, 2010  |   Pubmed ID: 20525693
• Regulation of CCAAT/enhancer-binding Protein Homologous Protein (CHOP) Expression by Interleukin-1 Beta in Pancreatic Beta Cells
  The Journal of Biological Chemistry. Jun, 2010  |   Pubmed ID: 20424162
• Multiple Chromatin-bound Protein Kinases Assemble Factors That Regulate Insulin Gene Transcription
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009  |   Pubmed ID: 20018749
• WNK Kinases and Blood Pressure Control
  Current Hypertension Reports. Dec, 2009  |   Pubmed ID: 19895753
• MAP-ping Unconventional Protein-DNA Interactions
  Cell. Oct, 2009  |   Pubmed ID: 19879834
• Radial Spoke Protein 3 is a Mammalian Protein Kinase A-anchoring Protein That Binds ERK1/2
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19684019
• FAK Phosphorylation by ERK Primes Ras-induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST
  Molecular Cell. Jul, 2009  |   Pubmed ID: 19595712
• Crystal Structure of Domain-swapped STE20 OSR1 Kinase Domain
  Protein Science : a Publication of the Protein Society. Feb, 2009  |   Pubmed ID: 19177573
• The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer
  Structure (London, England : 1993). Jan, 2009  |   Pubmed ID: 19141286
• PTMap--a Sequence Alignment Software for Unrestricted, Accurate, and Full-spectrum Identification of Post-translational Modification Sites
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009  |   Pubmed ID: 19136633
• Regulation of a Third Conserved Phosphorylation Site in SGK1
  The Journal of Biological Chemistry. Feb, 2009  |   Pubmed ID: 19068477
• Sumoylation Regulates the Transcriptional Activity of MafA in Pancreatic Beta Cells
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 19029092
• Chromatin-bound Mitogen-activated Protein Kinases Transmit Dynamic Signals in Transcription Complexes in Beta-cells
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008  |   Pubmed ID: 18755896
• The Roles of MAPKs in Disease
  Cell Research. Apr, 2008  |   Pubmed ID: 18347614
• WNKs: Protein Kinases with a Unique Kinase Domain
  Experimental & Molecular Medicine. Oct, 2007  |   Pubmed ID: 18059132
• WNK1 is a Novel Regulator of Munc18c-syntaxin 4 Complex Formation in Soluble NSF Attachment Protein Receptor (SNARE)-mediated Vesicle Exocytosis
  The Journal of Biological Chemistry. Nov, 2007  |   Pubmed ID: 17848561
• Mutations in ERK2 Binding Sites Affect Nuclear Entry
  The Journal of Biological Chemistry. Sep, 2007  |   Pubmed ID: 17656361
• Differential Regulation of CHOP-10/GADD153 Gene Expression by MAPK Signaling in Pancreatic Beta-cells
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007  |   Pubmed ID: 17615236
• TAO Kinases Mediate Activation of P38 in Response to DNA Damage
  The EMBO Journal. Apr, 2007  |   Pubmed ID: 17396146
• Biological Cross-talk Between WNK1 and the Transforming Growth Factor Beta-Smad Signaling Pathway
  The Journal of Biological Chemistry. Jun, 2007  |   Pubmed ID: 17392271
• Mxi2 Promotes Stimulus-independent ERK Nuclear Translocation
  The EMBO Journal. Feb, 2007  |   Pubmed ID: 17255949
• Characterization of Mitogen-activated Protein Kinase (MAPK) Dimers
  Biochemistry. Nov, 2006  |   Pubmed ID: 17073439
• Expression and Characterization of MAP Kinases in Bacteria
  Methods (San Diego, Calif.). Nov, 2006  |   Pubmed ID: 16908184
• WNK1 and OSR1 Regulate the Na+, K+, 2Cl- Cotransporter in HeLa Cells
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006  |   Pubmed ID: 16832045
• The Transcriptional ETS2 Repressor Factor Associates with Active and Inactive Erks Through Distinct FXF Motifs
  The Journal of Biological Chemistry. Sep, 2006  |   Pubmed ID: 16799155
• Role of With-no-lysine [K] Kinases in the Pathogenesis of Gordon's Syndrome
  Pediatric Nephrology (Berlin, Germany). Sep, 2006  |   Pubmed ID: 16683163
• The MAP Kinase ERK5 Binds to and Phosphorylates P90 RSK
  Archives of Biochemistry and Biophysics. May, 2006  |   Pubmed ID: 16626623
• The Nuclear Localization of ERK2 Occurs by Mechanisms Both Independent of and Dependent on Energy
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16595679
• Cyclic AMP Selectively Uncouples Mitogen-activated Protein Kinase Cascades from Activating Signals
  Molecular and Cellular Biology. Apr, 2006  |   Pubmed ID: 16581779
• Inhibition of Glucose-stimulated Activation of Extracellular Signal-regulated Protein Kinases 1 and 2 by Epinephrine in Pancreatic Beta-cells
  Diabetes. Apr, 2006  |   Pubmed ID: 16567530
• TGF-beta Regulation by Emilin1: New Links in the Etiology of Hypertension
  Cell. Mar, 2006  |   Pubmed ID: 16530037
• Activation of MEKK1 by Rho GTPases
  Methods in Enzymology. 2006  |   Pubmed ID: 16472679
• WNK1 Activates SGK1 by a Phosphatidylinositol 3-kinase-dependent and Non-catalytic Mechanism
  The Journal of Biological Chemistry. Oct, 2005  |   Pubmed ID: 16081417
• WNK1 Activates SGK1 to Regulate the Epithelial Sodium Channel
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005  |   Pubmed ID: 16006511
• ERK1/2-dependent Activation of Transcription Factors Required for Acute and Chronic Effects of Glucose on the Insulin Gene Promoter
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15899886
• Properties of WNK1 and Implications for Other Family Members
  The Journal of Biological Chemistry. Jul, 2005  |   Pubmed ID: 15883153
• Context-dependent Regulation of NeuroD Activity and Protein Accumulation
  Molecular and Cellular Neurosciences. Apr, 2005  |   Pubmed ID: 15797719
• WNK1: Analysis of Protein Kinase Structure, Downstream Targets, and Potential Roles in Hypertension
  Cell Research. Jan, 2005  |   Pubmed ID: 15686619
• Stimulus-coupled Spatial Restriction of Extracellular Signal-regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-response Pathways
  Molecular and Cellular Biology. Dec, 2004  |   Pubmed ID: 15542825
• Crystal Structure of the TAO2 Kinase Domain: Activation and Specificity of a Ste20p MAP3K
  Structure (London, England : 1993). Oct, 2004  |   Pubmed ID: 15458637
• WNK1 Phosphorylates Synaptotagmin 2 and Modulates Its Membrane Binding
  Molecular Cell. Sep, 2004  |   Pubmed ID: 15350218
• MAP Kinases and Their Roles in Pancreatic Beta-cells
  Cell Biochemistry and Biophysics. 2004  |   Pubmed ID: 15289654
• Protein Kinase Function and Glutathionylation
  The Biochemical Journal. Aug, 2004  |   Pubmed ID: 15270699
• Crystal Structure of the Kinase Domain of WNK1, a Kinase That Causes a Hereditary Form of Hypertension
  Structure (London, England : 1993). Jul, 2004  |   Pubmed ID: 15242606
• Structure of MAPKs
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 14755085
• The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions
  The Journal of Biological Chemistry. Mar, 2004  |   Pubmed ID: 14707138
• Characterization of OSR1, a Member of the Mammalian Ste20p/germinal Center Kinase Subfamily
  The Journal of Biological Chemistry. Mar, 2004  |   Pubmed ID: 14707132
• WNK1 Activates ERK5 by an MEKK2/3-dependent Mechanism
  The Journal of Biological Chemistry. Feb, 2004  |   Pubmed ID: 14681216
• RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity
  The Journal of Biological Chemistry. Jan, 2004  |   Pubmed ID: 14581471
• MAP Kinase Modules: Many Roads Home
  Current Biology : CB. Nov, 2003  |   Pubmed ID: 14614847
• Regulation of Insulin Gene Transcription by ERK1 and ERK2 in Pancreatic Beta Cells
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12810726
• Regulation of ERK1 and ERK2 by Glucose and Peptide Hormones in Pancreatic Beta Cells
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12783880
• TAO (thousand-and-one Amino Acid) Protein Kinases Mediate Signaling from Carbachol to P38 Mitogen-activated Protein Kinase and Ternary Complex Factors
  The Journal of Biological Chemistry. Jun, 2003  |   Pubmed ID: 12665513
• Overview of the Alliance for Cellular Signaling
  Nature. Dec, 2002  |   Pubmed ID: 12478301
• Regulation of WNK1 by an Autoinhibitory Domain and Autophosphorylation
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12374799
• Stimulus-specific Requirements for MAP3 Kinases in Activating the JNK Pathway
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12351623
• Cell Condition-dependent Regulation of ERK5 by CAMP
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12297510
• Binding of JNK/SAPK to MEKK1 is Regulated by Phosphorylation
  The Journal of Biological Chemistry. Nov, 2002  |   Pubmed ID: 12228228
• P115 Rho GTPase Activating Protein Interacts with MEKK1
  Journal of Cellular Physiology. Aug, 2002  |   Pubmed ID: 12115726
• Crystal Structures of MAP Kinase P38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b
  Molecular Cell. Jun, 2002  |   Pubmed ID: 12086621
• The PHD Domain of MEKK1 Acts As an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2
  Molecular Cell. May, 2002  |   Pubmed ID: 12049732
• ERK2 Enters the Nucleus by a Carrier-independent Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. May, 2002  |   Pubmed ID: 12032311
• Sulindac Enhances Tumor Necrosis Factor-alpha-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-kappaB
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002  |   Pubmed ID: 11839649
• Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1
  The Journal of Biological Chemistry. Apr, 2002  |   Pubmed ID: 11823456
• Pharmacological Inhibitors of MAPK Pathways
  Trends in Pharmacological Sciences. Jan, 2002  |   Pubmed ID: 11804650
• Different Domains of the Mitogen-activated Protein Kinases ERK3 and ERK2 Direct Subcellular Localization and Upstream Specificity in Vivo
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11741894