Mercedes Gonzalez-Juarrero Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology Colorado State University Biography Publications Institution JoVE Articles Mercedes Gonzalez-Juarrero has not added a biography. If you are Mercedes Gonzalez-Juarrero and would like to personalize this page please email our Author Liaison for assistance. Publications Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics Pharmaceutics. Jun, 2023 | Pubmed ID: 37376207 Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium Abscessus Burden Antimicrobial Agents and Chemotherapy. Jun, 2023 | Pubmed ID: 37154689 Characterization of Spectinamide 1599 Efficacy Against Different Mycobacterial Phenotypes Tuberculosis (Edinburgh, Scotland). May, 2023 | Pubmed ID: 37120915 Spray Dried Tigecycline Dry Powder Aerosols for the Treatment of Nontuberculous Mycobacterial Pulmonary Infections Tuberculosis (Edinburgh, Scotland). Mar, 2023 | Pubmed ID: 36716525 Microbiological Profile, Preclinical Pharmacokinetics and Efficacy of CRS0393, a Novel Antimycobacterial Agent Targeting MmpL3 Tuberculosis (Edinburgh, Scotland). Jan, 2023 | Pubmed ID: 36470124 Mucosal Exposure to Non-tuberculous Mycobacteria Elicits B Cell-mediated Immunity Against Pulmonary Tuberculosis Cell Reports. Dec, 2022 | Pubmed ID: 36516760 Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy Life (Basel, Switzerland). Jul, 2022 | Pubmed ID: 36013317 Mycobacterium Leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico Emerging Infectious Diseases. Mar, 2022 | Pubmed ID: 35202538 Therapeutic Efficacy of Antimalarial Drugs Targeting DosRS Signaling in Science Translational Medicine. Feb, 2022 | Pubmed ID: 35196022 Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium Frontiers in Microbiology. 2021 | Pubmed ID: 34777289 Lipid Nanoparticle Formulation of Niclosamide (nano NCM) Effectively Inhibits SARS-CoV-2 Replication Precision Nanomedicine. Apr, 2021 | Pubmed ID: 34676370 Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy Against Tuberculosis ACS Infectious Diseases. Oct, 2021 | Pubmed ID: 34546724 Neonatal and Infant Immunity for Tuberculosis Vaccine Development: Importance of Age-matched Animal Models Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32988990 Inhaled Tigecycline is Effective Against Mycobacterium Abscessus in Vitro and in Vivo The Journal of Antimicrobial Chemotherapy. Jul, 2020 | Pubmed ID: 32294173 Minipigs As a Neonatal Animal Model for Tuberculosis Vaccine Efficacy Testing Veterinary Immunology and Immunopathology. Sep, 2019 | Pubmed ID: 31420066 Sterilization of Mycobacterium Tuberculosis Infected Samples Using Methanol Preserves Anti-tuberculosis Drugs for Subsequent Pharmacological Testing Studies Tuberculosis (Edinburgh, Scotland). Jul, 2019 | Pubmed ID: 31378268 Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599 Pharmaceutical Research. Jul, 2019 | Pubmed ID: 31321552 Direct Inhibition of MmpL3 by Novel Antitubercular Compounds ACS Infectious Diseases. Jun, 2019 | Pubmed ID: 30882198 Comparative Pharmacokinetics of Spectinamide 1599 After Subcutaneous and Intrapulmonary Aerosol Administration in Mice Tuberculosis (Edinburgh, Scotland). Jan, 2019 | Pubmed ID: 30711150 Host Directed Therapy for Chronic Tuberculosis Via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway Scientific Reports. Nov, 2018 | Pubmed ID: 30413750 Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent Frontiers in Microbiology. 2018 | Pubmed ID: 30294313 Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Frontiers in Microbiology. 2018 | Pubmed ID: 30186246 Interactions of Free-living Amoebae with Rice Bacterial Pathogens Xanthomonas Oryzae Pathovars Oryzae and Oryzicola PloS One. 2018 | Pubmed ID: 30142182 Cell Mediated Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Strain Rev. 1 Veterinary Immunology and Immunopathology. Aug, 2018 | Pubmed ID: 30078602 Evidence of Zoonotic Leprosy in Pará, Brazilian Amazon, and Risks Associated with Human Contact or Consumption of Armadillos PLoS Neglected Tropical Diseases. Jun, 2018 | Pubmed ID: 29953440 Yersinia Pestis Survival and Replication in Potential Ameba Reservoir Emerging Infectious Diseases. Feb, 2018 | Pubmed ID: 29350155 Evaluation of Shedding, Tissue Burdens, and Humoral Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Vaccine Strain Rev. 1 PloS One. 2017 | Pubmed ID: 29028813 The Minipig As an Animal Model to Study Mycobacterium Tuberculosis Infection and Natural Transmission Tuberculosis (Edinburgh, Scotland). Sep, 2017 | Pubmed ID: 28802411 Mycobacterium Bovis Hosted by Free-living-amoebae Permits Their Long-term Persistence Survival Outside of Host Mammalian Cells and Remain Capable of Transmitting Disease to Mice Environmental Microbiology. Oct, 2017 | Pubmed ID: 28585299 Therapeutic Potential of the Mycobacterium Tuberculosis Mycolic Acid Transporter, MmpL3 Antimicrobial Agents and Chemotherapy. Sep, 2016 | Pubmed ID: 27297488 Potential and Development of Inhaled RNAi Therapeutics for the Treatment of Pulmonary Tuberculosis Advanced Drug Delivery Reviews. 07, 2016 | Pubmed ID: 27108702 Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ ACS Central Science. Sep, 2015 | Pubmed ID: 26436137 Presence of Multiple Lesion Types with Vastly Different Microenvironments in C3HeB/FeJ Mice Following Aerosol Infection with Mycobacterium Tuberculosis Disease Models & Mechanisms. Jun, 2015 | Pubmed ID: 26035867 Extended Culture of Macrophages from Different Sources and Maturation Results in a Common M2 Phenotype Journal of Biomedical Materials Research. Part A. Sep, 2015 | Pubmed ID: 25684281 Long-term Survival and Virulence of Mycobacterium Leprae in Amoebal Cysts PLoS Neglected Tropical Diseases. Dec, 2014 | Pubmed ID: 25521850 Microhemorrhage is an Early Event in the Pulmonary Fibrotic Disease of PECAM-1 Deficient FVB/n Mice Experimental and Molecular Pathology. Aug, 2014 | Pubmed ID: 24972347 Spectinamides: a New Class of Semisynthetic Antituberculosis Agents That Overcome Native Drug Efflux Nature Medicine. Feb, 2014 | Pubmed ID: 24464186 GM-CSF Knockout Mice for Preclinical Testing of Agents with Antimicrobial Activity Against Mycobacterium Abscessus The Journal of Antimicrobial Chemotherapy. Apr, 2014 | Pubmed ID: 24222613 Polar Lipids of Burkholderia Pseudomallei Induce Different Host Immune Responses PloS One. 2013 | Pubmed ID: 24260378 Correlates of Immune Protection Following Cutaneous Immunization with an Attenuated Burkholderia Pseudomallei Vaccine Infection and Immunity. Dec, 2013 | Pubmed ID: 24101688 Experimental Aerosol Mycobacterium Bovis Model of Infection in Goats Tuberculosis (Edinburgh, Scotland). Sep, 2013 | Pubmed ID: 23850102 Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23155047 Mouse Model for Efficacy Testing of Antituberculosis Agents Via Intrapulmonary Delivery Antimicrobial Agents and Chemotherapy. Jul, 2012 | Pubmed ID: 22547626 Immunity to TB and Targets for Immunotherapy Immunotherapy. Feb, 2012 | Pubmed ID: 22339461 Glycolytic and Non-glycolytic Functions of Mycobacterium Tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21949126 Local Pulmonary Immunotherapy with SiRNA Targeting TGFβ1 Enhances Antimicrobial Capacity in Mycobacterium Tuberculosis Infected Mice Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 21195670 Optimization of Inhaled Therapies for Tuberculosis: the Role of Macrophages and Dendritic Cells Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 20888298 Multiple M. Tuberculosis Phenotypes in Mouse and Guinea Pig Lung Tissue Revealed by a Dual-staining Approach PloS One. 2010 | Pubmed ID: 20559431 Differential Polarization of Alveolar Macrophages and Bone Marrow-derived Monocytes Following Chemically and Pathogen-induced Chronic Lung Inflammation Journal of Leukocyte Biology. Jul, 2010 | Pubmed ID: 20360403 Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials The American Journal of Pathology. Jul, 2009 | Pubmed ID: 19528351 Lack of IL-10 Alters Inflammatory and Immune Responses During Pulmonary Mycobacterium Tuberculosis Infection Tuberculosis (Edinburgh, Scotland). Mar, 2009 | Pubmed ID: 19213603 Intrapulmonary Delivery of XCL1-targeting Small Interfering RNA in Mice Chronically Infected with Mycobacterium Tuberculosis American Journal of Respiratory Cell and Molecular Biology. Aug, 2009 | Pubmed ID: 19097989 Immune Response to Mycobacterium Tuberculosis and Identification of Molecular Markers of Disease American Journal of Respiratory Cell and Molecular Biology. Apr, 2009 | Pubmed ID: 18787176 Phenotypic Non-equivalence of Murine (monocyte-) Macrophage Cells in Biomaterial and Inflammatory Models Journal of Biomedical Materials Research. Part A. Mar, 2009 | Pubmed ID: 18357567 Interleukin-10 Promotes Mycobacterium Tuberculosis Disease Progression in CBA/J Mice Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18832712 Relative Levels of M-CSF and GM-CSF Influence the Specific Generation of Macrophage Populations During Infection with Mycobacterium Tuberculosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354213 Animal Models of M. Tuberculosis Infection Current Protocols in Microbiology. Nov, 2007 | Pubmed ID: 18770606 XCL1 (lymphotactin) Chemokine Produced by Activated CD8 T Cells During the Chronic Stage of Infection with Mycobacterium Tuberculosis Negatively Affects Production of IFN-gamma by CD4 T Cells and Participates in Granuloma Stability Journal of Leukocyte Biology. Nov, 2007 | Pubmed ID: 17699612 Cross-reaction of Anti-human CD Monoclonal Antibodies on Guinea Pig Cells: a Summary of the Guinea Pig Section of the HLDA8 Animal Homologues Data Veterinary Immunology and Immunopathology. Sep, 2007 | Pubmed ID: 17658620 Enhanced Macrophage Activity in Granulomatous Lesions of Immune Mice Challenged with Mycobacterium Tuberculosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585589 Virulent Clinical Isolates of Mycobacterium Tuberculosis Grow Rapidly and Induce Cellular Necrosis but Minimal Apoptosis in Murine Macrophages Journal of Leukocyte Biology. Jan, 2006 | Pubmed ID: 16275894 Foamy Macrophages Within Lung Granulomas of Mice Infected with Mycobacterium Tuberculosis Express Molecules Characteristic of Dendritic Cells and Antiapoptotic Markers of the TNF Receptor-associated Factor Family Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148133 Factors Associated with Severe Granulomatous Pneumonia in Mycobacterium Tuberculosis-infected Mice Vaccinated Therapeutically with Hsp65 DNA Infection and Immunity. Aug, 2005 | Pubmed ID: 16041037 Interleukin-10 Production by Lung Macrophages in CBA Xid Mutant Mice Infected with Mycobacterium Tuberculosis Immunology. Jun, 2005 | Pubmed ID: 15885131 Disruption of Granulocyte Macrophage-colony Stimulating Factor Production in the Lungs Severely Affects the Ability of Mice to Control Mycobacterium Tuberculosis Infection Journal of Leukocyte Biology. Jun, 2005 | Pubmed ID: 15767289 Stable T-cell Population Expressing an Effector Cell Surface Phenotype in the Lungs of Mice Chronically Infected with Mycobacterium Tuberculosis Infection and Immunity. Jan, 2004 | Pubmed ID: 14688138 NK Cells Respond to Pulmonary Infection with Mycobacterium Tuberculosis, but Play a Minimal Role in Protection Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634116 Dynamics of Macrophage Cell Populations During Murine Pulmonary Tuberculosis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12960339 Florid Pulmonary Inflammatory Responses in Mice Vaccinated with Antigen-85 Pulsed Dendritic Cells and Challenged by Aerosol with Mycobacterium Tuberculosis Cellular Immunology. Nov, 2002 | Pubmed ID: 12718935 In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002 | Pubmed ID: 12444141 Temporal and Spatial Arrangement of Lymphocytes Within Lung Granulomas Induced by Aerosol Infection with Mycobacterium Tuberculosis Infection and Immunity. Mar, 2001 | Pubmed ID: 11179349 Characterization of Murine Lung Dendritic Cells Infected with Mycobacterium Tuberculosis Infection and Immunity. Feb, 2001 | Pubmed ID: 11160010 Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Medicine Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunology and Infection
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Medicine
Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunology and Infection
