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Articles by Michael Chiang in JoVE

 JoVE Bioengineering

Gebruik van de Mens Perivasculaire stamcellen voor botregeneratie


JoVE 2952 5/25/2012

1Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, UCLA, 2UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, 3Department of Bioengineering, UCLA, 4Center for Cardiovascular Science, University of Edinburgh

Menselijke perivasculaire stamcellen (PSC's) zijn een nieuwe stamcel klasse voor het skelet weefselregeneratie vergelijkbaar met mesenchymale stamcellen (MSC's). PSC's kunnen worden geïsoleerd door FACS (fluorescentie geactiveerde cel sortering) uit vetweefsel verkregen tijdens standaard liposuctie procedures, dan gecombineerd met een osteoinductief steiger om botvorming te bereiken

Other articles by Michael Chiang on PubMed

Nardosinane Sesquiterpenoids from the Formosan Soft Coral Lemnalia Flava

Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 were shown to possess significant neuroprotective activity.

Retinopathy of Prematurity in Infants Weighing Less Than 500 Grams at Birth Enrolled in the Early Treatment for Retinopathy of Prematurity Study

To describe patient characteristics, classification, and onset of prethreshold retinopathy of prematurity (ROP), and ocular findings at 6 months corrected age in infants with birth weights <500 g who were enrolled in the Early Treatment for Retinopathy of Prematurity (ETROP) Study.

Secondary Metabolites from the Leaves of Neolitsea Hiiranensis and the Anti-inflammatory Activity of Some of Them

Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α-methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC(50) values of 21.86±3.97 and 25.78±4.77μM, respectively.

Sesquiterpenoids from the Formosan Soft Coral Lemnalia Flava

Four new nardosinane-type sesquiterpenoids, flavalins E-H (1-4) and two new nornardosinane-type norsesquiterpenoids, flavalins I (5) and J (6), along with five known compounds (7-11) have been isolated from a Formosan soft coral Lemnalia flava. The structures of these compounds were elucidated on the basis of their spectroscopic data. Moreover, the absolute configuration of 10 was further determined by Mosher's method.

Special Requirements for Electronic Health Record Systems in Ophthalmology

The field of ophthalmology has a number of unique features compared with other medical and surgical specialties regarding clinical workflow and data management. This has important implications for the design of electronic health record (EHR) systems that can be used intuitively and efficiently by ophthalmologists and that can promote improved quality of care. Ophthalmologists often lament the absence of these specialty-specific features in EHRs, particularly in systems that were developed originally for primary care physicians or other medical specialists. The purpose of this article is to summarize the special requirements of EHRs that are important for ophthalmology. The hope is that this will help ophthalmologists to identify important features when searching for EHR systems, to stimulate vendors to recognize and incorporate these functions into systems, and to assist federal agencies to develop future guidelines regarding meaningful use of EHRs. More broadly, the American Academy of Ophthalmology believes that these functions are elements of good system design that will improve access to relevant information at the point of care between the ophthalmologist and the patient, will enhance timely communications between primary care providers and ophthalmologists, will mitigate risk, and ultimately will improve the ability of physicians to deliver the highest-quality medical care. FINANCIAL DISCLOSURE(S): Proprietary or commercial interest disclosure may be found after the references.

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