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In JoVE (1)
Other Publications (1)
Articles by Michael Zimmerman in JoVE
Use of a Hanging-weight System for Liver Ischemia in Mice
Michael Zimmerman1, Eunyoung Tak2, Maria Kaplan1, Mercedes Susan Mandell2, Holger K. Eltzschig2, Almut Grenz2
1UCH Transplant Center, University of Colorado, Denver, 2Department of Anesthesiology, University of Colorado, Denver
We established a novel murine model of a hanging weight system for portal triad occlusion. This technique may be useful for future investigations of ischemia in murine hepatic models.
Other articles by Michael Zimmerman on PubMed
Transplantation. Jan, 2011 | Pubmed ID: 21200363
Donation after cardiac death (DCD) kidneys suffer a high incidence of delayed graft function attributable to warm ischemia and cold ischemia (CI). Neither the mechanism of injury nor type of cell death has been described. Clinical studies suggest that perfusion storage (PS) of DCD kidneys may reduce injury although the mechanism of protection is unknown. In a porcine model of DCD, we hypothesized that DCD kidneys have increased caspase-1 due to warm ischemia (WI) and increased caspase-3 and apoptosis due to CI.