Articles by Morgan E. Webb in JoVE

Large Scale Zebrafish-Based In vivo Small Molecule Screen

JoVE 2243 12/30/2010

Jijun Hao¹, Charles H. Williams¹, Morgan E. Webb¹, Charles C. Hong^1,2,3,4

¹Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, ²Department of Pharmacology, Vanderbilt University School of Medicine, ³Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, ⁴Research Medicine, Veterans Affairs TVHS, Vanderbilt University School of Medicine

Zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.