Nadia Rosenthal National Heart and Lung Institute Imperial College London Biography Publications Institution JoVE Articles Nadia Rosenthal has not added a biography. If you are Nadia Rosenthal and would like to personalize this page please email our Author Liaison for assistance. Publications Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-angiogenesis Following Myocardial Infarction PloS One. 2013 | Pubmed ID: 24265802 Cardiac Fibrosis in Mice Expressing an Inducible Myocardial-specific Cre Driver Disease Models & Mechanisms. Nov, 2013 | Pubmed ID: 23929940 Macrophages Are Required for Adult Salamander Limb Regeneration Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23690624 Functional Characterization of a Novel Mutation in NKX2-5 Associated with Congenital Heart Disease and Adult-Onset Cardiomyopathy Circulation. Cardiovascular Genetics. May, 2013 | Pubmed ID: 23661673 Isolation and Analysis of Single Cells from the Mouse Heart Journal of Immunological Methods. Jul, 2013 | Pubmed ID: 23578979 Nerve Growth Factor Stimulates Cardiac Regeneration Via Cardiomyocyte Proliferation in Experimental Heart Failure PloS One. 2012 | Pubmed ID: 23300892 E-peptides Control Bioavailability of IGF-1 PloS One. 2012 | Pubmed ID: 23251442 The Mammalian Gene Function Resource: the International Knockout Mouse Consortium Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012 | Pubmed ID: 22968824 Beyond Knockouts: Cre Resources for Conditional Mutagenesis Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012 | Pubmed ID: 22926223 Follistatin-like 3 Mediates Paracrine Fibroblast Activation by Cardiomyocytes Journal of Cardiovascular Translational Research. Dec, 2012 | Pubmed ID: 22915069 CreZOO--the European Virtual Repository of Cre and Other Targeted Conditional Driver Strains Database : the Journal of Biological Databases and Curation. 2012 | Pubmed ID: 22730454 Myocardial Regenerative Properties of Macrophage Populations and Stem Cells Journal of Cardiovascular Translational Research. Oct, 2012 | Pubmed ID: 22684511 An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-activated Macrophage Profile PloS One. 2012 | Pubmed ID: 22590615 Locally Expressed IGF1 Propeptide Improves Mouse Heart Function in Induced Dilated Cardiomyopathy by Blocking Myocardial Fibrosis and SRF-dependent CTGF Induction Disease Models & Mechanisms. Jul, 2012 | Pubmed ID: 22563064 In Search of a Wide-angle Perspective Differentiation; Research in Biological Diversity. Mar, 2012 | Pubmed ID: 22364883 Proximal Tubule Overexpression of a Locally Acting IGF Isoform, Igf-1Ea, Increases Inflammation After Ischemic Injury Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society. Feb, 2012 | Pubmed ID: 22197584 MIGF-1/JNK1/SirT1 Signaling Confers Protection Against Oxidative Stress in the Heart Aging Cell. Feb, 2012 | Pubmed ID: 22051242 Insulin-like Growth Factor-1 Overexpression in Cardiomyocytes Diminishes Ex Vivo Heart Functional Recovery After Acute Ischemia Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Jan-Feb, 2012 | Pubmed ID: 21266309 Increased Cardiogenesis in P19-GFP Teratocarcinoma Cells Expressing the Propeptide IGF-1Ea Biochemical and Biophysical Research Communications. Dec, 2011 | Pubmed ID: 22100652 Complex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5 PloS One. 2011 | Pubmed ID: 21931855 MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation Circulation Research. Oct, 2011 | Pubmed ID: 21903938 Calcineurin Splicing Variant Calcineurin Aβ1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy Circulation. Jun, 2011 | Pubmed ID: 21632490 IGF-1Ea Induces Vessel Formation After Injury and Mediates Bone Marrow and Heart Cross-talk Through the Expression of Specific Cytokines Biochemical and Biophysical Research Communications. Jul, 2011 | Pubmed ID: 21621517 Cre Recombinase Resources for Conditional Mouse Mutagenesis Methods (San Diego, Calif.). Apr, 2011 | Pubmed ID: 21195764 Research Funding. Sustaining the Data and Bioresource Commons Science (New York, N.Y.). Oct, 2010 | Pubmed ID: 21030633 Regulation of Muscle Atrophy in Aging and Disease Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20886766 Finding and Sharing: New Approaches to Registries of Databases and Services for the Biomedical Sciences Database : the Journal of Biological Databases and Curation. 2010 | Pubmed ID: 20627863 Mouse Resource Browser--a Database of Mouse Databases Database : the Journal of Biological Databases and Curation. 2010 | Pubmed ID: 20627861 Revealing New Mouse Epicardial Cell Markers Through Transcriptomics PloS One. 2010 | Pubmed ID: 20596535 Serum and Glucocorticoid-inducible Kinase 1 (SGK1) is Necessary for Vascular Remodeling During Angiogenesis Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2010 | Pubmed ID: 20568246 Comments on Point:Counterpoint: IGF Is/is Not the Major Physiological Regulator of Muscle Mass. IGF-1 is a Major Regulator of Muscle Mass During Growth but Not for Adult Myofiber Hypertrophy Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2010 | Pubmed ID: 20527703 SirT1 in Muscle Physiology and Disease: Lessons from Mouse Models Disease Models & Mechanisms. May-Jun, 2010 | Pubmed ID: 20354108 Local IGF-1 Isoform Protects Cardiomyocytes from Hypertrophic and Oxidative Stresses Via SirT1 Activity Aging. 2010 | Pubmed ID: 20228935 Analysis of Cardiac Myocyte Biology in Transgenic Mice: a Protocol for Preparation of Neonatal Mouse Cardiac Myocyte Cultures Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20204624 A Growth Stimulus is Needed for IGF-1 to Induce Skeletal Muscle Hypertrophy in Vivo Journal of Cell Science. Mar, 2010 | Pubmed ID: 20179101 Insights into the Organization of Dorsal Spinal Cord Pathways from an Evolutionarily Conserved Raldh2 Intronic Enhancer Development (Cambridge, England). Feb, 2010 | Pubmed ID: 20081195 Distinct Roles for Cell-autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart Circulation Research. Feb, 2010 | Pubmed ID: 20007915 Models for Financial Sustainability of Biological Databases and Resources Database : the Journal of Biological Databases and Curation. 2009 | Pubmed ID: 20157490 A CREB-C/EBPbeta Cascade Induces M2 Macrophage-specific Gene Expression and Promotes Muscle Injury Repair Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19805133 Post-publication Sharing of Data and Tools Nature. Sep, 2009 | Pubmed ID: 19741686 Multiple Congenital Malformations of Wolf-Hirschhorn Syndrome Are Recapitulated in Fgfrl1 Null Mice Disease Models & Mechanisms. May-Jun, 2009 | Pubmed ID: 19383940 Skeletal Muscle is a Primary Target of SOD1G93A-mediated Toxicity Cell Metabolism. Nov, 2008 | Pubmed ID: 19046573 Overexpression of MIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice The American Journal of Pathology. Nov, 2008 | Pubmed ID: 18832567 Analysis of CRE-mediated Recombination Driven by Myosin Light Chain 1/3 Regulatory Elements in Embryonic and Adult Skeletal Muscle: a Tool to Study Fiber Specification Genesis (New York, N.Y. : 2000). Aug, 2008 | Pubmed ID: 18693277 Expression of Follistatin-related Genes is Altered in Heart Failure Endocrinology. Nov, 2008 | Pubmed ID: 18617621 Interleukin-10 from Transplanted Bone Marrow Mononuclear Cells Contributes to Cardiac Protection After Myocardial Infarction Circulation Research. Jul, 2008 | Pubmed ID: 18566343 Reliability, Robustness, and Reproducibility in Mouse Behavioral Phenotyping: a Cross-laboratory Study Physiological Genomics. Aug, 2008 | Pubmed ID: 18505770 NF-kappaB Signaling in Skeletal Muscle: Prospects for Intervention in Muscle Diseases Journal of Molecular Medicine (Berlin, Germany). Jul, 2008 | Pubmed ID: 18246321 Derive and Conquer: Sourcing and Differentiating Stem Cells for Therapeutic Applications Nature Reviews. Drug Discovery. Feb, 2008 | Pubmed ID: 18079756 A Naturally Occurring Calcineurin Variant Inhibits FoxO Activity and Enhances Skeletal Muscle Regeneration The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086917 The Mouse Ascending: Perspectives for Human-disease Models Nature Cell Biology. Sep, 2007 | Pubmed ID: 17762889 Phenostat: Visualization and Statistical Tool for Analysis of Phenotyping Data Mammalian Genome : Official Journal of the International Mammalian Genome Society. Sep, 2007 | Pubmed ID: 17674099 ROCK2 and Its Alternatively Spliced Isoform ROCK2m Positively Control the Maturation of the Myogenic Program Molecular and Cellular Biology. Sep, 2007 | Pubmed ID: 17606625 Immune Response to Stem Cells and Strategies to Induce Tolerance Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Aug, 2007 | Pubmed ID: 17584730 Enhancing Repair of the Mammalian Heart Circulation Research. Jun, 2007 | Pubmed ID: 17525368 Identification of Novel Peptide Hormones in the Human Proteome by Hidden Markov Model Screening Genome Research. Mar, 2007 | Pubmed ID: 17284679 Local Expression of IGF-1 Accelerates Muscle Regeneration by Rapidly Modulating Inflammatory Cytokines and Chemokines FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2007 | Pubmed ID: 17264161 The Neuroprotective Effects of a Locally Acting IGF-1 Isoform Experimental Gerontology. Jan-Feb, 2007 | Pubmed ID: 16782294 Targeted Ablation of IKK2 Improves Skeletal Muscle Strength, Maintains Mass, and Promotes Regeneration The Journal of Clinical Investigation. Nov, 2006 | Pubmed ID: 17080195 Signalling Pathways in Cardiac Regeneration Novartis Foundation Symposium. 2006 | Pubmed ID: 17019815 Growth Factor Enhancement of Cardiac Regeneration Cell Transplantation. 2006 | Pubmed ID: 16826794 The Future of Regenerative Therapy in Patients with Chronic Heart Failure Nature Clinical Practice. Cardiovascular Medicine. Mar, 2006 | Pubmed ID: 16501620 IGF-1, Inflammation and Stem Cells: Interactions During Muscle Regeneration Trends in Immunology. Oct, 2005 | Pubmed ID: 16109502 Transgenic Overexpression of Locally Acting Insulin-like Growth Factor-1 Inhibits Ubiquitin-mediated Muscle Atrophy in Chronic Left-ventricular Dysfunction Circulation Research. Sep, 2005 | Pubmed ID: 16051886 Youthful Prospects for Human Stem-cell Therapy. In Another Few Decades, Revised Attitudes Toward Stem Cells Could Lead to Disease Prevention and Life Extension EMBO Reports. Jul, 2005 | Pubmed ID: 15995658 Vasopressin-dependent Myogenic Cell Differentiation is Mediated by Both Ca2+/calmodulin-dependent Kinase and Calcineurin Pathways Molecular Biology of the Cell. Aug, 2005 | Pubmed ID: 15930130 Insulin-like Growth Factor I-mediated Skeletal Muscle Hypertrophy is Characterized by Increased MTOR-p70S6K Signaling Without Increased Akt Phosphorylation Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research. Apr, 2005 | Pubmed ID: 15921033 Reconciling Data from Transgenic Mice That Overexpress IGF-I Specifically in Skeletal Muscle Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society. Feb, 2005 | Pubmed ID: 15701567 Muscle Expression of a Local Igf-1 Isoform Protects Motor Neurons in an ALS Mouse Model The Journal of Cell Biology. Jan, 2005 | Pubmed ID: 15657392 Muscle-specific Expression of IGF-1 Blocks Angiotensin II-induced Skeletal Muscle Wasting The Journal of Clinical Investigation. Feb, 2005 | Pubmed ID: 15650772 Human Hepatocytes in Mice Receiving Pre-immune Injection with Human Cord Blood Cells Biochemical and Biophysical Research Communications. Jan, 2005 | Pubmed ID: 15567153 Targeted Expression of Insulin-like Growth Factor-I Reduces Early Myofiber Necrosis in Dystrophic Mdx Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2004 | Pubmed ID: 15509501 The European Dimension for the Mouse Genome Mutagenesis Program Nature Genetics. Sep, 2004 | Pubmed ID: 15340424 The Stem Cell Challenge Scientific American. Jun, 2004 | Pubmed ID: 15195398 Stem Cell-mediated Muscle Regeneration is Enhanced by Local Isoform of Insulin-like Growth Factor 1 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14745025 A Caudorostral Wave of RALDH2 Conveys Anteroposterior Information to the Cardiac Field Development (Cambridge, England). Nov, 2003 | Pubmed ID: 13129847 Developmental Basis of Evolutionary Digit Loss in the Australian Lizard Hemiergis Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution. Jun, 2003 | Pubmed ID: 12955843 Prometheus's Vulture and the Stem-cell Promise The New England Journal of Medicine. Jul, 2003 | Pubmed ID: 12867611 Normal Female Sexual Development Requires Neuregulin-erbB Receptor Signaling in Hypothalamic Astrocytes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2003 | Pubmed ID: 12514220 Machinations of the Marrow The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12511584 Taking Stock of Our Models: the Function and Future of Stock Centres Nature Reviews. Genetics. Sep, 2002 | Pubmed ID: 12209145 Gene Therapy for Cardiac Cachexia? International Journal of Cardiology. Sep, 2002 | Pubmed ID: 12163223 The Role of Stem Cells in Skeletal and Cardiac Muscle Repair The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. May, 2002 | Pubmed ID: 11967271 Muscle-specific Expression of Insulin-like Growth Factor I Counters Muscle Decline in Mdx Mice The Journal of Cell Biology. Apr, 2002 | Pubmed ID: 11927606 Targeted Deletion of the MLC1f/3f Downstream Enhancer Results in Precocious MLC Expression and Mesoderm Ablation Developmental Biology. Mar, 2002 | Pubmed ID: 11884037 Different Modes of Hypertrophy in Skeletal Muscle Fibers The Journal of Cell Biology. Feb, 2002 | Pubmed ID: 11839766 Intramyocardial Cell Delivery: Observations in Murine Hearts Tommaso Poggioli1,2, Padmini Sarathchandra1,2, Nadia Rosenthal2,3, Maria P. Santini1,2 1Magdi Yacoub Institute, Imperial College London, 2National Heart and Lung Institute, Imperial College London, 3Australian Regenerative Medicine Institute, Monash University JoVE 51064 Medicine
Intramyocardial Cell Delivery: Observations in Murine Hearts Tommaso Poggioli1,2, Padmini Sarathchandra1,2, Nadia Rosenthal2,3, Maria P. Santini1,2 1Magdi Yacoub Institute, Imperial College London, 2National Heart and Lung Institute, Imperial College London, 3Australian Regenerative Medicine Institute, Monash University JoVE 51064 Medicine