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In JoVE (1)
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Articles by Nadjar Nitz in JoVE
JoVE Immunology and Infection
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
Chagas Disease Multidisciplinary Research Laboratory, University of Brasilia
The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.
