Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 21 三体综合征相关的缺陷,在通过揭示人类原始造血诱导多能干细胞。 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 从人类胚胎干细胞生成的胚祖行自我更新。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 胚体分化的胚胎干细胞的高通量检测。 Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 血管内皮细胞巢诱导肝规范通过双重压制 Wnt 和槽口的信号。 Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 鼠标 ES 和 IPS 细胞可以形成类似明确内的胚层尽管印迹基因存在着差异。 The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 高吞吐量多路复用优化的人类胚胎干细胞的无血清分化议定书筛查结果分析。 Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 肝再生植株诱导多能干细胞。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 使用单个可抽税慢病毒干细胞卡带的转基因无肺疾病特定人类诱导多能干干细胞的生成。 Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 转录能力和活动标记的定义的转录因子在胚胎和诱导多能干细胞的组织特异性增强剂。 Genes & Development. Dec, 2009 | Pubmed ID: 20008934 干细胞解读卵黄囊造血功能。 Blood. Aug, 2009 | Pubmed ID: 19696206 表示对早期鼠标内胚层细胞表面分子的单克隆抗体的生成。 Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 表皮细胞加速重新编程。 Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 麻木介导 Wnt 和凹槽调节原始 Erythropoietic 规格从 Hemangioblast 之间的相互作用。 Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 Wnt、 激活素,和 BMP 信号调节血液从胚胎干细胞发育途径中的不同阶段。 Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 识别和 ROSA26 轨迹在人类胚胎干细胞的靶向。 Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 骨形态发生蛋白-4 是必需的肝内胚小鼠胚胎干细胞最终层的规范。 Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 需要原始纹形成使用胚胎干细胞体外模型的诱导 Wnt 和 TGF-β 信号。 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 胚层诱导胚胎干细胞。 Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 恢复的自然杀伤 T 细胞发育的 TCR Fyn 突变小鼠揭示了个体发育早期 NK T 细胞 Fyn 的一个必要条件。 Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 Mer 受体酪氨酸激酶: 表达式和函数建议在天然免疫中的作用。 European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 NK T 细胞前体展示鉴别细胞因子调节及需要 Itk 高效成熟的。 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 在人类多能干细胞中使用CRISPR-CAS9生成定义的基因组修饰 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics 代人类诱导多能干细胞从外周血中使用STEMCCA慢病毒载体 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
在人类多能干细胞中使用CRISPR-CAS9生成定义的基因组修饰 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics
代人类诱导多能干细胞从外周血中使用STEMCCA慢病毒载体 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology