Peter Besmer Developmental Biology Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Peter Besmer has not added a biography. If you are Peter Besmer and would like to personalize this page please email our Author Liaison for assistance. Publications CD133 and CD44 Are Universally Overexpressed in GIST and Do Not Represent Cancer Stem Cell Markers Genes, Chromosomes & Cancer. Feb, 2012 | Pubmed ID: 22076958 Imatinib Potentiates Antitumor T Cell Responses in Gastrointestinal Stromal Tumor Through the Inhibition of Ido Nature Medicine. Sep, 2011 | Pubmed ID: 21873989 Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and is More Effective when Combined with Dasatinib Molecular Cancer Research : MCR. Sep, 2010 | Pubmed ID: 20736294 Kit Ligand Cytoplasmic Domain is Essential for Basolateral Sorting in Vivo and Has Roles in Spermatogenesis and Hematopoiesis Developmental Biology. Jan, 2010 | Pubmed ID: 19874813 Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: an in Vitro Mutagenesis Screen for Drug Resistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2009 | Pubmed ID: 19861442 Kit Signaling Via PI3K Promotes Ovarian Follicle Maturation but is Dispensable for Primordial Follicle Activation Developmental Biology. Jul, 2009 | Pubmed ID: 19447101 A KIT Juxtamembrane PY567 -directed Pathway Provides Nonredundant Signals for Erythroid Progenitor Cell Development and Stress Erythropoiesis Experimental Hematology. Feb, 2009 | Pubmed ID: 19100679 Changes in the Structure and Function of ICC Networks in ICC Hyperplasia and Gastrointestinal Stromal Tumors Gastroenterology. Feb, 2009 | Pubmed ID: 19032955 Novel V600E BRAF Mutations in Imatinib-naive and Imatinib-resistant Gastrointestinal Stromal Tumors Genes, Chromosomes & Cancer. Oct, 2008 | Pubmed ID: 18615679 Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008 | Pubmed ID: 18483389 Tumor Mitotic Rate, Size, and Location Independently Predict Recurrence After Resection of Primary Gastrointestinal Stromal Tumor (GIST) Cancer. Feb, 2008 | Pubmed ID: 18076015 Sorafenib Inhibits the Imatinib-resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2007 | Pubmed ID: 17699867 L576P KIT Mutation in Anal Melanomas Correlates with KIT Protein Expression and is Sensitive to Specific Kinase Inhibition International Journal of Cancer. Journal International Du Cancer. Jul, 2007 | Pubmed ID: 17372901 Histone H2AX is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis Following Treatment with Imatinib Mesylate Cancer Research. Mar, 2007 | Pubmed ID: 17363589 Different ADAMs Have Distinct Influences on Kit Ligand Processing: Phorbol-ester-stimulated Ectodomain Shedding of Kitl1 by ADAM17 is Reduced by ADAM19 Journal of Cell Science. Mar, 2007 | Pubmed ID: 17344430 Pathologic and Molecular Heterogeneity in Imatinib-stable or Imatinib-responsive Gastrointestinal Stromal Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2007 | Pubmed ID: 17200352 Comparative Ultrastructural Analysis and KIT/PDGFRA Genotype in 125 Gastrointestinal Stromal Tumors Ultrastructural Pathology. Nov-Dec, 2006 | Pubmed ID: 17182437 Oncogenic Kit Signaling and Therapeutic Intervention in a Mouse Model of Gastrointestinal Stromal Tumor Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16908864 The Scaffolding Adapter Gab2, Via Shp-2, Regulates Kit-evoked Mast Cell Proliferation by Activating the Rac/JNK Pathway The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16873377 A Distant Upstream Locus Control Region is Critical for Expression of the Kit Receptor Gene in Mast Cells Molecular and Cellular Biology. Aug, 2006 | Pubmed ID: 16847336 Lyn Kinase Promotes Erythroblast Expansion and Late-stage Development Blood. Sep, 2006 | Pubmed ID: 16705093 Extracellular KIT Receptor Mutants, Commonly Found in Core Binding Factor AML, Are Constitutively Active and Respond to Imatinib Mesylate Blood. Dec, 2005 | Pubmed ID: 16081693 Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2005 | Pubmed ID: 15930355 Gastrointestinal Stromal Tumors in Children and Young Adults: a Clinicopathologic, Molecular, and Genomic Study of 15 Cases and Review of the Literature Journal of Pediatric Hematology/oncology. Apr, 2005 | Pubmed ID: 15838387 Multiple Gastrointestinal Stromal Tumors in Type I Neurofibromatosis: a Pathologic and Molecular Study Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Apr, 2005 | Pubmed ID: 15540118 Gene Expression in Gastrointestinal Stromal Tumors is Distinguished by KIT Genotype and Anatomic Site Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2004 | Pubmed ID: 15161681 Critical Role for Kit-mediated Src Kinase but Not PI 3-kinase Signaling in Pro T and Pro B Cell Development The Journal of Experimental Medicine. Mar, 2004 | Pubmed ID: 15024050 Pleomorphic Characteristics of a Germ-line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2004 | Pubmed ID: 14977822 Association of KIT Exon 9 Mutations with Nongastric Primary Site and Aggressive Behavior: KIT Mutation Analysis and Clinical Correlates of 120 Gastrointestinal Stromal Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2003 | Pubmed ID: 12960119 A Role for Kit Receptor Signaling in Leydig Cell Steroidogenesis Biology of Reproduction. Sep, 2003 | Pubmed ID: 12773427 Gastrointestinal Stromal Tumors in a Mouse Model by Targeted Mutation of the Kit Receptor Tyrosine Kinase Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12754375 Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-ligand Cell. May, 2002 | Pubmed ID: 12062105 Avian Bic, a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-induced Lymphomas That Encodes a Noncoding RNA, Cooperates with C-myc in Lymphomagenesis and Erythroleukemogenesis Journal of Virology. May, 2002 | Pubmed ID: 11932393 Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice Yu Chen1,2, Tambudzai Shamu2, Hui Chen3, Peter Besmer3, Charles L. Sawyers2,4, Ping Chi1,5 1Department of Medicine, Memorial Sloan Kettering Cancer Center, 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Howard Hughes, Medical Institute, 5Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University JoVE 2802 Biology
Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice Yu Chen1,2, Tambudzai Shamu2, Hui Chen3, Peter Besmer3, Charles L. Sawyers2,4, Ping Chi1,5 1Department of Medicine, Memorial Sloan Kettering Cancer Center, 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Howard Hughes, Medical Institute, 5Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University JoVE 2802 Biology
