Petr Džubák

Publications

• Synthesis and Cytostatic and Antiviral Profiling of Thieno-fused 7-Deazapurine Ribonucleosides
  Journal of Medicinal Chemistry. Feb, 2017  |   Pubmed ID: 28221790
• Cytotoxic Conjugates of Betulinic Acid and Substituted Triazoles Prepared by Huisgen Cycloaddition from 30-azidoderivatives
  PloS One. 2017  |   Pubmed ID: 28158265
• The Natural Cytokinin 2OH3MeOBAR Induces Cell Death by a Mechanism That is Different from That of the "classical" Cytokinin Ribosides
  Phytochemistry. Apr, 2017  |   Pubmed ID: 28153445
• Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid
  ChemMedChem. Jan, 2017  |   Pubmed ID: 28084676
• Cell-based DNA Demethylation Detection System for Screening of Epigenetic Drugs in 2D, 3D, and Xenograft Models
  Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Feb, 2017  |   Pubmed ID: 27911980
• Trilobolide-steroid Hybrids: Synthesis, Cytotoxic and Antimycobacterial Activity
  Steroids. Jan, 2017  |   Pubmed ID: 27543674
• Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response
  Current Pharmaceutical Design. 2016  |   Pubmed ID: 27573929
• The Dual Role of Asporin in Breast Cancer Progression
  Oncotarget. Aug, 2016  |   Pubmed ID: 27409832
• Lupane and 18α-oleanane Derivatives Substituted in the Position 2, Their Cytotoxicity and Influence on Cancer Cells
  European Journal of Medicinal Chemistry. Oct, 2016  |   Pubmed ID: 27236068
• Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation
  Journal of Biomolecular Screening. Oct, 2016  |   Pubmed ID: 27226477
• Biodegradable System for Drug Delivery of Hydrolytically Labile Azanucleoside Drugs
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2016  |   Pubmed ID: 27003313
• Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes
  BioMed Research International. 2016  |   Pubmed ID: 26942188
• 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action
  Molecular Cancer Therapeutics. May, 2016  |   Pubmed ID: 26819331
• Synthesis and Biological Profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides
  Bioorganic & Medicinal Chemistry. Dec, 2015  |   Pubmed ID: 26558518
• Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin
  Bioconjugate Chemistry. Dec, 2015  |   Pubmed ID: 26537839
• Synthesis of Cytotoxic 2,2-difluoroderivatives of Dihydrobetulinic Acid and Allobetulin and Study of Their Impact on Cancer Cells
  European Journal of Medicinal Chemistry. 2015  |   Pubmed ID: 25942059
• Caffeine-hydrazones As Anticancer Agents with Pronounced Selectivity Toward T-lymphoblastic Leukaemia Cells
  Bioorganic Chemistry. Jun, 2015  |   Pubmed ID: 25912310
• 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity
  ChemMedChem. Jun, 2015  |   Pubmed ID: 25882678
• Synthesis and Biological Activity Evaluation of Hydrazone Derivatives Based on a Tröger's Base Skeleton
  Bioorganic & Medicinal Chemistry. Apr, 2015  |   Pubmed ID: 25737088
• Affinity-based Methods in Drug-target Discovery
  Current Drug Targets. 2015  |   Pubmed ID: 25410410
• Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides
  Journal of Medicinal Chemistry. Oct, 2014  |   Pubmed ID: 25259627
• Hepcidin Levels in Diamond-Blackfan Anemia Reflect Erythropoietic Activity and Transfusion Dependency
  Haematologica. Jul, 2014  |   Pubmed ID: 24727814
• Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-substituted 7-(het)aryl-7-deazapurine Ribonucleosides
  Journal of Medicinal Chemistry. Feb, 2014  |   Pubmed ID: 24397620
• Combination of Prednisolone and Low Dosed Dexamethasone Exhibits Greater in Vitro Antileukemic Activity Than Equiactive Dose of Prednisolone and Overcomes Prednisolone Drug Resistance in Acute Childhood Lymphoblastic Leukemia
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Sep, 2014  |   Pubmed ID: 23128824
• Preparation, Preliminary Screening of New Types of Steroid Conjugates and Their Activities on Steroid Receptors
  Steroids. Mar, 2013  |   Pubmed ID: 23291595
• Cancer Cell Response to Anthracyclines Effects: Mysteries of the Hidden Proteins Associated with These Drugs
  International Journal of Molecular Sciences. Nov, 2012  |   Pubmed ID: 23443080
• Cytotoxic Heterocyclic Triterpenoids Derived from Betulin and Betulinic Acid
  Bioorganic & Medicinal Chemistry. Jun, 2012  |   Pubmed ID: 22551630
• Aurora Kinase Inhibitors: Progress Towards the Clinic
  Investigational New Drugs. Dec, 2012  |   Pubmed ID: 22350019
• Synthesis of Various 5-alkoxymethyluracil Analogues and Structure-cytotoxic Activity Relationship Study
  Carbohydrate Research. Oct, 2011  |   Pubmed ID: 21864833
• Synthesis and Significant Cytostatic Activity of 7-hetaryl-7-deazaadenosines
  Journal of Medicinal Chemistry. Aug, 2011  |   Pubmed ID: 21711054
• 2-phenylsubstituted-3-hydroxyquinolin-4(1H)-one-carboxamides: Structure-cytotoxic Activity Relationship Study
  ACS Combinatorial Science. Jan, 2011  |   Pubmed ID: 21247123
• Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and Study of Their Cytotoxic Activity
  European Journal of Medicinal Chemistry. Sep, 2010  |   Pubmed ID: 20605656
• Anticancer Activity of Natural Cytokinins: a Structure-activity Relationship Study
  Phytochemistry. Aug, 2010  |   Pubmed ID: 20553699
• 6-(Het)aryl-7-deazapurine Ribonucleosides As Novel Potent Cytostatic Agents
  Journal of Medicinal Chemistry. Jan, 2010  |   Pubmed ID: 19929004
• Utilization of High-accuracy FTICR-MS Data in Protein Quantitation Experiments
  Journal of Mass Spectrometry : JMS. Nov, 2009  |   Pubmed ID: 19536796
• The Anti-inflammatory Effects of Inhaled Corticosteroids Versus Anti-leukotrienes on the Lymphocyte P-glycoprotein (PGP) Expression in Asthmatic Children
  The Journal of Asthma : Official Journal of the Association for the Care of Asthma. May, 2009  |   Pubmed ID: 19484671
• Functional P53 in Cells Contributes to the Anticancer Effect of the Cyclin-dependent Kinase Inhibitor Roscovitine
  Journal of Cellular Biochemistry. Jun, 2009  |   Pubmed ID: 19308936
• Cyclocondensation Reaction of Heterocyclic Carbonyl Compounds. Part XIII: Synthesis and Cytotoxic Activity of Some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines
  European Journal of Medicinal Chemistry. Feb, 2009  |   Pubmed ID: 18632190
• Aurora Kinases: Structure, Functions and Their Association with Cancer
  Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2008  |   Pubmed ID: 18795071
• Synthesis and Cytotoxic Activity of Various 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils in Their Racemic Form
  Bioorganic & Medicinal Chemistry Letters. Dec, 2007  |   Pubmed ID: 17935983
• 4-arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects
  Journal of Medicinal Chemistry. Nov, 2006  |   Pubmed ID: 17064068
• Comblike Dendrimers Containing Tn Antigen Modulate Natural Killing and Induce the Production of Tn Specific Antibodies
  Journal of Medicinal Chemistry. Oct, 2006  |   Pubmed ID: 17034145
• Pharmacological Activities of Natural Triterpenoids and Their Therapeutic Implications
  Natural Product Reports. Jun, 2006  |   Pubmed ID: 16741586
• New Derivatives of Silybin and 2,3-dehydrosilybin and Their Cytotoxic and P-glycoprotein Modulatory Activity
  Bioorganic & Medicinal Chemistry. Jun, 2006  |   Pubmed ID: 16466920
• Influence of Esterification and Modification of A-ring in a Group of Lupane Acids on Their Cytotoxicity
  Bioorganic & Medicinal Chemistry. Oct, 2005  |   Pubmed ID: 16087342
• Protein Fingerprints of Anti-cancer Effects of Cyclin-dependent Kinase Inhibition: Identification of Candidate Biomarkers Using 2-D Liquid Phase Separation Coupled to Mass Spectrometry
  Technology in Cancer Research & Treatment. Aug, 2005  |   Pubmed ID: 16029063
• Synthesis of Phthalates of Betulinic Acid and Betulin with Cytotoxic Activity
  Bioorganic & Medicinal Chemistry. May, 2005  |   Pubmed ID: 15848757
• The Synthetic Ligand of Peroxisome Proliferator-activated Receptor-gamma Ciglitazone Affects Human Glioblastoma Cell Lines
  The Journal of Pharmacology and Experimental Therapeutics. Jun, 2004  |   Pubmed ID: 14988421
• New Lupane Derived Compounds with Pro-apoptotic Activity in Cancer Cells: Synthesis and Structure-activity Relationships
  Journal of Medicinal Chemistry. Dec, 2003  |   Pubmed ID: 14640549
• Analysis of State-specific Phosphorylation of Proteins by Two-dimensional Gel Electrophoresis Approach
  Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Apr, 2003  |   Pubmed ID: 12659733
• Application of Proteomics in the Search for Novel Proteins Associated with the Anti-cancer Effect of the Synthetic Cyclin-dependent Kinases Inhibitor, Bohemine
  Technology in Cancer Research & Treatment. Aug, 2002  |   Pubmed ID: 12625783