Articles by R. Nika Nudelman in JoVE

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

JoVE 2257 8/04/2011

Marcella A. Calfon¹, Amir Rosenthal^1,2, Georgios Mallas^1,3, Adam Mauskapf¹, R. Nika Nudelman², Vasilis Ntziachristos², Farouc A. Jaffer¹

¹Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, ²Institute for Biological and Medical Imaging, Helmholtz Zentrum München und Technische Universität München, ³Department of Electrical and Computer Engineering, Northeastern University

We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy that utilizes a novel in vivo intravascular NIRF catheter to image and quantify inflammatory plaque in proteolytically active inflamed rabbit atheromata.