Rajiv Chopra Imaging Research Sunnybrook Research Institute Biography Publications Institution JoVE Articles Rajiv Chopra has not added a biography. If you are Rajiv Chopra and would like to personalize this page please email our Author Liaison for assistance. Publications Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery Radiology. Feb, 2012 | Pubmed ID: 22344400 Investigation of Power and Frequency for 3D Conformal MRI-controlled Transurethral Ultrasound Therapy with a Dual Frequency Multi-element Transducer International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2012 | Pubmed ID: 22235788 Thermally-triggered 'off-on-off' Response of Gadolinium-hydrogel-lipid Hybrid Nanoparticles Defines a Customizable Temperature Window for Non-invasive Magnetic Resonance Imaging Thermometry Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2012 | Pubmed ID: 21939700 New Pyrazolyl and Thienyl Aminohydantoins As Potent BACE1 Inhibitors: Exploring the S2' Region Bioorganic & Medicinal Chemistry Letters. Sep, 2011 | Pubmed ID: 21835615 The Feasibility of Endorectal MR Elastography for Prostate Cancer Localization Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Dec, 2011 | Pubmed ID: 21574182 Development of a Platform for Co-registered Ultrasound and MR Contrast Imaging in Vivo Physics in Medicine and Biology. Feb, 2011 | Pubmed ID: 21242630 Localised Drug Release Using MRI-controlled Focused Ultrasound Hyperthermia International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2011 | Pubmed ID: 21158487 Transurethral Prostate Magnetic Resonance Elastography: Prospective Imaging Requirements Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Feb, 2011 | Pubmed ID: 20882673 MRI-controlled Transurethral Ultrasound Therapy for Localised Prostate Cancer International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2010 | Pubmed ID: 21043572 4-(Pyrazol-4-yl)-pyrimidines As Selective Inhibitors of Cyclin-dependent Kinase 4/6 Journal of Medicinal Chemistry. Nov, 2010 | Pubmed ID: 21038853 3D Conformal MRI-controlled Transurethral Ultrasound Prostate Therapy: Validation of Numerical Simulations and Demonstration in Tissue-mimicking Gel Phantoms Physics in Medicine and Biology. Nov, 2010 | Pubmed ID: 21030751 A Lead Discovery Strategy Driven by a Comprehensive Analysis of Proteases in the Peptide Substrate Space Protein Science : a Publication of the Protein Society. Nov, 2010 | Pubmed ID: 20799349 MRI-guided Transurethral Ultrasound Therapy of the Prostate Gland Using Real-time Thermal Mapping: Initial Studies Urology. Dec, 2010 | Pubmed ID: 20709381 Simulation Study on the Heating of the Surrounding Anatomy During Transurethral Ultrasound Prostate Therapy: a 3D Theoretical Analysis of Patient Safety Medical Physics. Jun, 2010 | Pubmed ID: 20632598 Influence of Exposure Time and Pressure Amplitude on Blood-brain-barrier Opening Using Transcranial Ultrasound Exposures ACS Chemical Neuroscience. May, 2010 | Pubmed ID: 20563295 Antibodies Targeted to the Brain with Image-guided Focused Ultrasound Reduces Amyloid-beta Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease PloS One. 2010 | Pubmed ID: 20485502 Novel Pyrrolyl 2-aminopyridines As Potent and Selective Human Beta-secretase (BACE1) Inhibitors Bioorganic & Medicinal Chemistry Letters. Apr, 2010 | Pubmed ID: 20223661 Pyridinyl Aminohydantoins As Small Molecule BACE1 Inhibitors Bioorganic & Medicinal Chemistry Letters. Apr, 2010 | Pubmed ID: 20202842 Di-substituted Pyridinyl Aminohydantoins As Potent and Highly Selective Human Beta-secretase (BACE1) Inhibitors Bioorganic & Medicinal Chemistry. Jan, 2010 | Pubmed ID: 20045648 Design and Synthesis of 5,5'-disubstituted Aminohydantoins As Potent and Selective Human Beta-secretase (BACE1) Inhibitors Journal of Medicinal Chemistry. Feb, 2010 | Pubmed ID: 19968289 Discovery and Initial Optimization of 5,5'-disubstituted Aminohydantoins As Potent Beta-secretase (BACE1) Inhibitors Bioorganic & Medicinal Chemistry Letters. Jan, 2010 | Pubmed ID: 19959359 MEK1 Mutations Confer Resistance to MEK and B-RAF Inhibition Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19915144 MR Acoustic Radiation Force Imaging: in Vivo Comparison to Ultrasound Motion Tracking Medical Physics. Jun, 2009 | Pubmed ID: 19610290 In Vivo MR Elastography of the Prostate Gland Using a Transurethral Actuator Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2009 | Pubmed ID: 19572390 An MRI-compatible System for Focused Ultrasound Experiments in Small Animal Models Medical Physics. May, 2009 | Pubmed ID: 19544806 Analysis of the Spatial and Temporal Accuracy of Heating in the Prostate Gland Using Transurethral Ultrasound Therapy and Active MR Temperature Feedback Physics in Medicine and Biology. May, 2009 | Pubmed ID: 19351975 Quantitative Analysis of 3-D Conformal MRI-guided Transurethral Ultrasound Therapy of the Prostate: Theoretical Simulations International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. Mar, 2009 | Pubmed ID: 19337912 Triad of Polar Residues Implicated in PH Specificity of Acidic Mammalian Chitinase Protein Science : a Publication of the Protein Society. Mar, 2009 | Pubmed ID: 19241384 Crystal Structure of Human CDK4 in Complex with a D-type Cyclin Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19237565 In Vivo Monitoring of Focused Ultrasound Surgery Using Local Harmonic Motion Ultrasound in Medicine & Biology. Jan, 2009 | Pubmed ID: 18805626 Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796 Antimicrobial Agents and Chemotherapy. Sep, 2008 | Pubmed ID: 18559648 MRI-compatible Transurethral Ultrasound System for the Treatment of Localized Prostate Cancer Using Rotational Control Medical Physics. Apr, 2008 | Pubmed ID: 18491529 Discovery of Benzisoxazoles As Potent Inhibitors of Chaperone Heat Shock Protein 90 Journal of Medicinal Chemistry. Feb, 2008 | Pubmed ID: 18197612 Acylguanidine Inhibitors of Beta-secretase: Optimization of the Pyrrole Ring Substituents Extending into the S1 and S3 Substrate Binding Pockets Bioorganic & Medicinal Chemistry Letters. Feb, 2008 | Pubmed ID: 18162398 Acylguanidine Inhibitors of Beta-secretase: Optimization of the Pyrrole Ring Substituents Extending into the S1' Substrate Binding Pocket Bioorganic & Medicinal Chemistry Letters. Jan, 2008 | Pubmed ID: 18068983 Progress in Multimodality Imaging: Truly Simultaneous Ultrasound and Magnetic Resonance Imaging IEEE Transactions on Medical Imaging. Dec, 2007 | Pubmed ID: 18092742 Thiophene Substituted Acylguanidines As BACE1 Inhibitors Bioorganic & Medicinal Chemistry Letters. Oct, 2007 | Pubmed ID: 17761418 Prostate Tissue Analysis Immediately Following Magnetic Resonance Imaging Guided Transurethral Ultrasound Thermal Therapy The Journal of Urology. Sep, 2007 | Pubmed ID: 17644137 Naphthyl Tetronic Acids As Multi-target Inhibitors of Bacterial Peptidoglycan Biosynthesis ChemMedChem. Oct, 2007 | Pubmed ID: 17600795 Identification of Anthranilic Acid Derivatives As a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase Journal of Medicinal Chemistry. May, 2007 | Pubmed ID: 17402724 Acylguanidines As Small-molecule Beta-secretase Inhibitors Journal of Medicinal Chemistry. Oct, 2006 | Pubmed ID: 17034121 Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-dependent RNA Polymerase Inhibitor Antimicrobial Agents and Chemotherapy. Dec, 2006 | Pubmed ID: 16940072 Discovery of Proline Sulfonamides As Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site Journal of Medicinal Chemistry. Jun, 2006 | Pubmed ID: 16722622 A Novel Approach to Identifying Beta-secretase Inhibitors: Bis-statine Peptide Mimetics Discovered Using Structure and Spot Synthesis Peptides. Jul, 2006 | Pubmed ID: 16574278 Analysis of Factors Important for Transurethral Ultrasound Prostate Heating Using MR Temperature Feedback Physics in Medicine and Biology. Feb, 2006 | Pubmed ID: 16467581 3,5-dioxopyrazolidines, Novel Inhibitors of UDP-N- Acetylenolpyruvylglucosamine Reductase (MurB) with Activity Against Gram-positive Bacteria Antimicrobial Agents and Chemotherapy. Feb, 2006 | Pubmed ID: 16436710 Method for MRI-guided Conformal Thermal Therapy of Prostate with Planar Transurethral Ultrasound Heating Applicators Physics in Medicine and Biology. Nov, 2005 | Pubmed ID: 16237234 Synthesis and Structure-activity Relationship of Novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones As Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget Journal of Medicinal Chemistry. Aug, 2005 | Pubmed ID: 16078826 Multi-modality Tissue-mimicking Phantom for Thermal Therapy Physics in Medicine and Biology. Jul, 2004 | Pubmed ID: 15285246 Synthesis and SAR of Bis-statine Based Peptides As BACE 1 Inhibitors Bioorganic & Medicinal Chemistry Letters. Jul, 2004 | Pubmed ID: 15177452 Elongation of Synthetic RNA Templates by Hepatitis C Virus NS5B Polymerase The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14688285 Multifrequency Ultrasound Transducers for Conformal Interstitial Thermal Therapy IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Jul, 2003 | Pubmed ID: 12894921 Identification, Characterization, and Crystal Structure of Bacillus Subtilis Nicotinic Acid Mononucleotide Adenylyltransferase The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11704676 MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model Meaghan A. O'Reilly1, Adam C. Waspe1,2, Rajiv Chopra1,2, Kullervo Hynynen1,3 1Imaging Research, Sunnybrook Research Institute, 2Department of Medical Biophysics, University of Toronto, 3Department of Medical Biophysics, and Institute of Biomaterials & Biomedical Engineering (IBBME), University of Toronto JoVE 3555 Medicine
MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model Meaghan A. O'Reilly1, Adam C. Waspe1,2, Rajiv Chopra1,2, Kullervo Hynynen1,3 1Imaging Research, Sunnybrook Research Institute, 2Department of Medical Biophysics, University of Toronto, 3Department of Medical Biophysics, and Institute of Biomaterials & Biomedical Engineering (IBBME), University of Toronto JoVE 3555 Medicine
