Raymond Chuen-Chung Chang Laboratory of Neurodegenerative Disease, Li Ka Shing Faculty of Medicine University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (HK SAR) Biography Publications Institution JoVE Articles Raymond Chuen-Chung Chang has not added a biography. If you are Raymond Chuen-Chung Chang and would like to personalize this page please email our Author Liaison for assistance. Publications The Beneficial Effects of Physical Exercise in the Brain and Related Pathophysiological Mechanisms in Neurodegenerative Diseases Laboratory Investigation; a Journal of Technical Methods and Pathology. Feb, 2019 | Pubmed ID: 30808929 Palmitate and Stearate Are Increased in the Plasma in a 6-OHDA Model of Parkinson's Disease Metabolites. Feb, 2019 | Pubmed ID: 30781729 Varenicline Reduces DNA Damage, Tau Mislocalization and Post Surgical Cognitive Impairment in Aged Mice Neuropharmacology. 12, 2018 | Pubmed ID: 30273594 Silica Nanoparticles Induce Neurodegeneration-like Changes in Behavior, Neuropathology, and Affect Synapse Through MAPK Activation Particle and Fibre Toxicology. Jul, 2018 | Pubmed ID: 29970116 Evidence of the Impact of Systemic Inflammation on Neuroinflammation from a Non-bacterial Endotoxin Animal Model Journal of Neuroinflammation. May, 2018 | Pubmed ID: 29776428 Bringing CLARITY to the Human Brain: Visualization of Lewy Pathology in Three Dimensions Neuropathology and Applied Neurobiology. 10, 2016 | Pubmed ID: 26526972 Editorial: Bioactive Small Molecules in Regulating Inflammation and Metabolic Disorder Current Topics in Medicinal Chemistry. 2016 | Pubmed ID: 26381415 PKR Deficiency Alters E. Coli-induced Sickness Behaviors but Does Not Exacerbate Neuroimmune Responses or Bacterial Load Journal of Neuroinflammation. Nov, 2015 | Pubmed ID: 26585788 Sickness: From the Focus on Cytokines, Prostaglandins, and Complement Factors to the Perspectives of Neurons Neuroscience and Biobehavioral Reviews. Oct, 2015 | Pubmed ID: 26363665 Investigating Degeneration of the Retina in Young and Aged Tau P301L Mice Life Sciences. Mar, 2015 | Pubmed ID: 25592136 Neuropathology of Cigarette Smoking Acta Neuropathologica. Jan, 2014 | Pubmed ID: 24240736 From Small to Big Molecules: How Do We Prevent and Delay the Progression of Age-related Neurodegeneration? Current Pharmaceutical Design. 2012 | Pubmed ID: 22211681 Lycium Barbarum Polysaccharides Protect Mice Liver from Carbon Tetrachloride-induced Oxidative Stress and Necroinflammation Journal of Ethnopharmacology. Jan, 2012 | Pubmed ID: 22138659 Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis Journal of Alzheimer's Disease : JAD. Nov, 2011 | Pubmed ID: 22101233 Neurodegeneration of the Retina in Mouse Models of Alzheimer's Disease: What Can We Learn from the Retina? Age (Dordrecht, Netherlands). May, 2011 | Pubmed ID: 21559868 Drug Discovery from Chinese Medicine Against Neurodegeneration in Alzheimer's and Vascular Dementia Chinese Medicine. 2011 | Pubmed ID: 21513513 Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/reperfusion Injury PloS One. 2011 | Pubmed ID: 21298100 Light Deprivation Induces Depression-like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones Unguiculatus) Cell Transplantation. 2011 | Pubmed ID: 21054936 Temporal Relationship of Autophagy and Apoptosis in Neurons Challenged by Low Molecular Weight β-amyloid Peptide Journal of Cellular and Molecular Medicine. Feb, 2011 | Pubmed ID: 20015199 Sulfur-containing Constituents and One 1H-pyrrole-2-carboxylic Acid Derivative from Pineapple [Ananas Comosus (L.) Merr.] Fruit Phytochemistry. Dec, 2010 | Pubmed ID: 20843530 Modulation of Mitochondrial Calcium As a Pharmacological Target for Alzheimer's Disease Ageing Research Reviews. Oct, 2010 | Pubmed ID: 20553970 Beneficial Effects of Cinnamon Proanthocyanidins on the Formation of Specific Advanced Glycation Endproducts and Methylglyoxal-induced Impairment on Glucose Consumption Journal of Agricultural and Food Chemistry. Jun, 2010 | Pubmed ID: 20476737 The Putative Neurodegenerative Links Between Depression and Alzheimer's Disease Progress in Neurobiology. Aug, 2010 | Pubmed ID: 20441786 Up-regulation of Crystallins is Involved in the Neuroprotective Effect of Wolfberry on Survival of Retinal Ganglion Cells in Rat Ocular Hypertension Model Journal of Cellular Biochemistry. May, 2010 | Pubmed ID: 20336662 Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium Barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20157238 Transcriptional Regulation of Human FE65, a Ligand of Alzheimer's Disease Amyloid Precursor Protein, by Sp1 Journal of Cellular Biochemistry. Mar, 2010 | Pubmed ID: 20091743 Modulation of Morphological Changes of Microglia and Neuroprotection by Monocyte Chemoattractant Protein-1 in Experimental Glaucoma Cellular & Molecular Immunology. Jan, 2010 | Pubmed ID: 20081877 A Pro-drug of the Green Tea Polyphenol (-)-epigallocatechin-3-gallate (EGCG) Prevents Differentiated SH-SY5Y Cells from Toxicity Induced by 6-hydroxydopamine Neuroscience Letters. Jan, 2010 | Pubmed ID: 20026175 Anti-aging Herbal Medicine--how and Why Can They Be Used in Aging-associated Neurodegenerative Diseases? Ageing Research Reviews. Jul, 2010 | Pubmed ID: 19833234 Protective Effects of Pinostilbene, a Resveratrol Methylated Derivative, Against 6-hydroxydopamine-induced Neurotoxicity in SH-SY5Y Cells The Journal of Nutritional Biochemistry. Jun, 2010 | Pubmed ID: 19443200 Erratum: Modulation of Microglia by Wolfberry on the Survival of Retinal Ganglion Cells in a Rat Ocular Hypertension Model Journal of Ocular Biology, Diseases, and Informatics. Sep, 2009 | Pubmed ID: 20046845 Modulation of Neuroimmune Responses on Glia in the Central Nervous System: Implication in Therapeutic Intervention Against Neuroinflammation Cellular & Molecular Immunology. Oct, 2009 | Pubmed ID: 19887044 Could PKR Inhibition Modulate Human Neurodegeneration? Expert Review of Neurotherapeutics. Oct, 2009 | Pubmed ID: 19831834 Modulation of Microglia by Wolfberry on the Survival of Retinal Ganglion Cells in a Rat Ocular Hypertension Model Journal of Ocular Biology, Diseases, and Informatics. Jun, 2009 | Pubmed ID: 19672466 Calcium Dysregulation in Alzheimer's Disease: from Mechanisms to Therapeutic Opportunities Progress in Neurobiology. Nov, 2009 | Pubmed ID: 19664678 Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical Neurons Cellular and Molecular Neurobiology. Dec, 2009 | Pubmed ID: 19499323 Low Molecular Weight Abeta Induces Collapse of Endoplasmic Reticulum Molecular and Cellular Neurosciences. May, 2009 | Pubmed ID: 19386229 Effects of All-trans-retinoic Acid on Human SH-SY5Y Neuroblastoma As in Vitro Model in Neurotoxicity Research Neurotoxicology. Jan, 2009 | Pubmed ID: 19056420 Dietary Oxyresveratrol Prevents Parkinsonian Mimetic 6-hydroxydopamine Neurotoxicity Free Radical Biology & Medicine. Oct, 2008 | Pubmed ID: 18675900 Antagonizing Beta-amyloid Peptide Neurotoxicity of the Anti-aging Fungus Ganoderma Lucidum Brain Research. Jan, 2008 | Pubmed ID: 18083148 Use of Anti-aging Herbal Medicine, Lycium Barbarum, Against Aging-associated Diseases. What Do We Know So Far? Cellular and Molecular Neurobiology. Aug, 2008 | Pubmed ID: 17710531 Characterization of the Effects of Anti-aging Medicine Fructus Lycii on Beta-amyloid Peptide Neurotoxicity International Journal of Molecular Medicine. Aug, 2007 | Pubmed ID: 17611646 Characterizing the Neuroprotective Effects of Alkaline Extract of Lycium Barbarum on Beta-amyloid Peptide Neurotoxicity Brain Research. Jul, 2007 | Pubmed ID: 17568570 New Polysaccharide from Nerium Indicum Protects Neurons Via Stress Kinase Signaling Pathway Brain Research. Jun, 2007 | Pubmed ID: 17475226 Neuroprotective Effects of Lycium Barbarum Lynn on Protecting Retinal Ganglion Cells in an Ocular Hypertension Model of Glaucoma Experimental Neurology. Jan, 2007 | Pubmed ID: 17045262 Significance of Molecular Signaling for Protein Translation Control in Neurodegenerative Diseases Neuro-Signals. -2007, 2006 | Pubmed ID: 17496426 Cytoprotective Effects of Lycium Barbarum Against Reducing Stress on Endoplasmic Reticulum International Journal of Molecular Medicine. Jun, 2006 | Pubmed ID: 16685430 Beta-amyloid Peptides Induces Neuronal Apoptosis Via a Mechanism Independent of Unfolded Protein Responses Apoptosis : an International Journal on Programmed Cell Death. May, 2006 | Pubmed ID: 16532272 Novel Neuroprotective Effects of the Aqueous Extracts from Verbena Officinalis Linn Neuropharmacology. May, 2006 | Pubmed ID: 16406021 Immune Modulatory Effects of Prunella Vulgaris L. on Monocytes/macrophages International Journal of Molecular Medicine. Dec, 2005 | Pubmed ID: 16273294 Neuroprotective Effects of Anti-aging Oriental Medicine Lycium Barbarum Against Beta-amyloid Peptide Neurotoxicity Experimental Gerontology. Aug-Sep, 2005 | Pubmed ID: 16139464 Stable Expression of EBERs in Immortalized Nasopharyngeal Epithelial Cells Confers Resistance to Apoptotic Stress Molecular Carcinogenesis. Oct, 2005 | Pubmed ID: 16086371 Immune Modulatory Effects of Prunella Vulgaris L International Journal of Molecular Medicine. Mar, 2005 | Pubmed ID: 15702244 Characterization of Polysaccharides from the Flowers of Nerium Indicum and Their Neuroprotective Effects International Journal of Molecular Medicine. Nov, 2004 | Pubmed ID: 15492866 Modulation of Calcium/calmodulin Kinase-II Provides Partial Neuroprotection Against Beta-amyloid Peptide Toxicity The European Journal of Neuroscience. Apr, 2004 | Pubmed ID: 15090032 Reduction of Calcium Release from the Endoplasmic Reticulum Could Only Provide Partial Neuroprotection Against Beta-amyloid Peptide Toxicity Journal of Neurochemistry. Dec, 2003 | Pubmed ID: 14713297 Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/threonine Protein Kinase in Beta-amyloid Peptide Neurotoxicity The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 12975376 BAD and Bcl-2 Regulation Are Early Events Linking Neuronal Endoplasmic Reticulum Stress to Mitochondria-mediated Apoptosis Brain Research. Molecular Brain Research. Dec, 2002 | Pubmed ID: 12531534 Involvement of Double-stranded RNA-dependent Protein Kinase and Phosphorylation of Eukaryotic Initiation Factor-2alpha in Neuronal Degeneration Journal of Neurochemistry. Dec, 2002 | Pubmed ID: 12437593 Uma bateria de testes comportamentais para a avaliação repetida das habilidades motoras, humor e cognição em ratos Ran You1,2,3, Yan Liu3, Raymond Chuen-Chung Chang3 1Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, 2Nanjing Key Laboratory of Pediatrics, Nanjing Medical University, 3Laboratory of Neurodegenerative Disease, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (HK SAR) JoVE 58973 Behavior Análises morfométricas de secções da retina Tin Fung Chan1, Kin Chiu1, Carmen Ka Ming Lok1, Wing Lau Ho1, Kwok-Fai So1,2,3, Raymond Chuen-Chung Chang1,2,3 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, 2Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, 3State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong JoVE 3377 Neuroscience Labeling retrógrada de células ganglionares da retina através da aplicação de Fluoro-Gold na superfície do colículo superior Kin Chiu1, Wui-Man Lau1, Sze-chun Yeung1, Raymond Chuen-Chung Chang1, Kwok-Fai So1 1The University of Hong Kong - HKU JoVE 819 Biology Injeção intravítrea para o Estabelecimento de Modelo de Doenças Ocular Kin Chiu1, Raymond Chuen-Chung Chang1, Kwok-Fai So1 1The University of Hong Kong - HKU JoVE 313 Biology Micro-dissecção de cérebro de um rato para RNA ou Extração de Proteína da região específica do cérebro Kin Chiu1, Wui Man Lau1, Ho Tak Lau1, Kwok-Fai So1, Raymond Chuen-Chung Chang1 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong - HKU JoVE 269 Biology
Uma bateria de testes comportamentais para a avaliação repetida das habilidades motoras, humor e cognição em ratos Ran You1,2,3, Yan Liu3, Raymond Chuen-Chung Chang3 1Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, 2Nanjing Key Laboratory of Pediatrics, Nanjing Medical University, 3Laboratory of Neurodegenerative Disease, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region (HK SAR) JoVE 58973 Behavior
Análises morfométricas de secções da retina Tin Fung Chan1, Kin Chiu1, Carmen Ka Ming Lok1, Wing Lau Ho1, Kwok-Fai So1,2,3, Raymond Chuen-Chung Chang1,2,3 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, 2Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, 3State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong JoVE 3377 Neuroscience
Labeling retrógrada de células ganglionares da retina através da aplicação de Fluoro-Gold na superfície do colículo superior Kin Chiu1, Wui-Man Lau1, Sze-chun Yeung1, Raymond Chuen-Chung Chang1, Kwok-Fai So1 1The University of Hong Kong - HKU JoVE 819 Biology
Injeção intravítrea para o Estabelecimento de Modelo de Doenças Ocular Kin Chiu1, Raymond Chuen-Chung Chang1, Kwok-Fai So1 1The University of Hong Kong - HKU JoVE 313 Biology
Micro-dissecção de cérebro de um rato para RNA ou Extração de Proteína da região específica do cérebro Kin Chiu1, Wui Man Lau1, Ho Tak Lau1, Kwok-Fai So1, Raymond Chuen-Chung Chang1 1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong - HKU JoVE 269 Biology
