JoVE Immunology and Infection
Fengyang Lei, Rizwanul Haque, Xiaofang Xiong, Jianxun Song
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine
Generation of T lymphocytes from induced pluripotent stem (iPS) cells gives an alternative approach of using embryonic stem cells for T cell-based immunotherapy. The method shows that by utilizing either in vitro or in vivo induction system, iPS cells are able to differentiate into both conventional and antigen-specific T lymphocytes.