Roger Y. Tsien Biography Publications JoVE Articles Roger Y. Tsien has not added a biography. If you are Roger Y. Tsien and would like to personalize this page please email our Author Liaison for assistance. Publications Optically Monitoring Voltage in Neurons by Photo-induced Electron Transfer Through Molecular Wires Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22308458 Concurrent Imaging of Synaptic Vesicle Recycling and Calcium Dynamics Frontiers in Molecular Neuroscience. 2011 | Pubmed ID: 22065946 A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms PLoS Biology. Apr, 2011 | Pubmed ID: 21483721 Improved Facial Nerve Identification with Novel Fluorescently Labeled Probe The Laryngoscope. Apr, 2011 | Pubmed ID: 21328585 Fluorescent Peptides Highlight Peripheral Nerves During Surgery in Mice Nature Biotechnology. Apr, 2011 | Pubmed ID: 21297616 Fluorescent Labeling of Tetracysteine-tagged Proteins in Intact Cells Nature Protocols. Sep, 2010 | Pubmed ID: 20885379 Fast 18F Labeling of a Near-infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes Bioconjugate Chemistry. Oct, 2010 | Pubmed ID: 20873712 Neuroligin Trafficking Deficiencies Arising from Mutations in the Alpha/beta-hydrolase Fold Protein Family The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20615874 Nobel Lecture: Constructing and Exploiting the Fluorescent Protein Paintbox Integrative Biology : Quantitative Biosciences from Nano to Macro. Mar, 2010 | Pubmed ID: 20473386 Parallel in Vivo and in Vitro Selection Using Phage Display Identifies Protease-dependent Tumor-targeting Peptides The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20460372 Simultaneous Visualization of Protumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer Cancer Research. Mar, 2010 | Pubmed ID: 20197470 Surgery with Molecular Fluorescence Imaging Using Activatable Cell-penetrating Peptides Decreases Residual Cancer and Improves Survival Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20160097 Activatable Cell Penetrating Peptides Linked to Nanoparticles As Dual Probes for in Vivo Fluorescence and MR Imaging of Proteases Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20160077 TimeSTAMP Tagging of Newly Synthesized Proteins Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [et Al.]. Feb, 2010 | Pubmed ID: 20155731 Indicators Based on Fluorescence Resonance Energy Transfer (FRET) Cold Spring Harbor Protocols. Jul, 2009 | Pubmed ID: 20147227 In Vivo Characterization of Activatable Cell Penetrating Peptides for Targeting Protease Activity in Cancer Integrative Biology : Quantitative Biosciences from Nano to Macro. Jun, 2009 | Pubmed ID: 20023745 Systemic in Vivo Distribution of Activatable Cell Penetrating Peptides is Superior to That of Cell Penetrating Peptides Integrative Biology : Quantitative Biosciences from Nano to Macro. Jun, 2009 | Pubmed ID: 20023744 Photoswitching Mechanism of Cyanine Dyes Journal of the American Chemical Society. Dec, 2009 | Pubmed ID: 19961226 Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals Chemistry & Biology. Nov, 2009 | Pubmed ID: 19942140 Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture) Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19565590 Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome Science (New York, N.Y.). May, 2009 | Pubmed ID: 19423828 Hairpin Structure of a Biarsenical-tetracysteine Motif Determined by NMR Spectroscopy Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19281235 Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics Biophysical Journal. Mar, 2009 | Pubmed ID: 19254539 Single-spike Detection in Vitro and in Vivo with a Genetic Ca2+ Sensor Nature Methods. Sep, 2008 | Pubmed ID: 19160514 Preparation of the Membrane-permeant Biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for Fluorescent Labeling of Tetracysteine-tagged Proteins Nature Protocols. 2008 | Pubmed ID: 18772880 A Drug-controllable Tag for Visualizing Newly Synthesized Proteins in Cells and Whole Animals Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18511556 Improving the Photostability of Bright Monomeric Orange and Red Fluorescent Proteins Nature Methods. Jun, 2008 | Pubmed ID: 18454154 Optical Measurement of Synaptic Glutamate Spillover and Reuptake by Linker Optimized Glutamate-sensitive Fluorescent Reporters Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18332427 Isoform-specific PKA Dynamics Revealed by Dye-triggered Aggregation and DAKAP1alpha-mediated Localization in Living Cells Chemistry & Biology. Sep, 2007 | Pubmed ID: 17884635 Calcium Green FlAsH As a Genetically Targeted Small-molecule Calcium Indicator Nature Chemical Biology. Jul, 2007 | Pubmed ID: 17572670 Exploration of New Chromophore Structures Leads to the Identification of Improved Blue Fluorescent Proteins Biochemistry. May, 2007 | Pubmed ID: 17444659 A Hexahistidine-Zn2+-dye Label Reveals STIM1 Surface Exposure Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360414 Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17189263 Evolving Proteins in Mammalian Cells Using Somatic Hypermutation Nature Protocols. 2006 | Pubmed ID: 17406421 Measuring Calcium Signaling Using Genetically Targetable Fluorescent Indicators Nature Protocols. 2006 | Pubmed ID: 17406387 Breeding and Building Molecules to Spy on Cells and Tumors The Keio Journal of Medicine. Dec, 2006 | Pubmed ID: 17191067 Imaging of CAMP Levels and Protein Kinase A Activity Reveals That Retinal Waves Drive Oscillations in Second-messenger Cascades The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2006 | Pubmed ID: 17151284 Golgi Twins in Late Mitosis Revealed by Genetically Encoded Tags for Live Cell Imaging and Correlated Electron Microscopy Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17101980 Systems Analysis of PKA-mediated Phosphorylation Gradients in Live Cardiac Myocytes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16905651 Novel Chromophores and Buried Charges Control Color in MFruits Biochemistry. Aug, 2006 | Pubmed ID: 16893165 Ca2+ Indicators Based on Computationally Redesigned Calmodulin-peptide Pairs Chemistry & Biology. May, 2006 | Pubmed ID: 16720273 The Fluorescent Toolbox for Assessing Protein Location and Function Science (New York, N.Y.). Apr, 2006 | Pubmed ID: 16614209 Control of Mammalian Translation by MRNA Structure Near Caps RNA (New York, N.Y.). May, 2006 | Pubmed ID: 16540693 Dynamics of the Upper 50-kDa Domain of Myosin V Examined with Fluorescence Resonance Energy Transfer The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16377637 Molecular Biology and Mutation of Green Fluorescent Protein Methods of Biochemical Analysis. 2006 | Pubmed ID: 16335711 A Guide to Choosing Fluorescent Proteins Nature Methods. Dec, 2005 | Pubmed ID: 16299475 Insulin Disrupts Beta-adrenergic Signalling to Protein Kinase A in Adipocytes Nature. Sep, 2005 | Pubmed ID: 16177793 Mammalian Cell-based Optimization of the Biarsenical-binding Tetracysteine Motif for Improved Fluorescence and Affinity Nature Biotechnology. Oct, 2005 | Pubmed ID: 16155565 Visualizing the Mechanical Activation of Src Nature. Apr, 2005 | Pubmed ID: 15846350 A FlAsH-based FRET Approach to Determine G Protein-coupled Receptor Activation in Living Cells Nature Methods. Mar, 2005 | Pubmed ID: 15782185 Building and Breeding Molecules to Spy on Cells and Tumors FEBS Letters. Feb, 2005 | Pubmed ID: 15680976 Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15583002 Tumor Imaging by Means of Proteolytic Activation of Cell-penetrating Peptides Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15601762 Bcl-2-mediated Alterations in Endoplasmic Reticulum Ca2+ Analyzed with an Improved Genetically Encoded Fluorescent Sensor Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15585581 Improved Monomeric Red, Orange and Yellow Fluorescent Proteins Derived from Discosoma Sp. Red Fluorescent Protein Nature Biotechnology. Dec, 2004 | Pubmed ID: 15558047 Evolution of New Nonantibody Proteins Via Iterative Somatic Hypermutation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15556995 BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress Molecular Cell. Aug, 2004 | Pubmed ID: 15304216 Bhc-cNMPs As Either Water-soluble or Membrane-permeant Photoreleasable Cyclic Nucleotides for Both One- and Two-photon Excitation Chembiochem : a European Journal of Chemical Biology. Aug, 2004 | Pubmed ID: 15300837 Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice Under TET Control PLoS Biology. Jun, 2004 | Pubmed ID: 15208716 Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 14985369 Imaging Tri-fusion Multimodality Reporter Gene Expression in Living Subjects Cancer Research. Feb, 2004 | Pubmed ID: 14973078 Activity-dependent Regulation of Dendritic Synthesis and Trafficking of AMPA Receptors Nature Neuroscience. Mar, 2004 | Pubmed ID: 14770185 Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14722062 Novel Fluorogenic Substrates for Imaging Beta-lactamase Gene Expression Journal of the American Chemical Society. Sep, 2003 | Pubmed ID: 16220906 Breeding Molecules to Spy on Cells Harvey Lectures. -2004, 2003 | Pubmed ID: 15984552 Tetracysteine Genetic Tags Complexed with Biarsenical Ligands As a Tool for Investigating Gap Junction Structure and Dynamics Cell Communication & Adhesion. Jul-Dec, 2003 | Pubmed ID: 14681013 Reversing Cerebellar Long-term Depression Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14671315 Imaging Tetrahymena Ribozyme Splicing Activity in Single Live Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14645710 Aptamers Switch on Fluorescence of Triphenylmethane Dyes Journal of the American Chemical Society. Dec, 2003 | Pubmed ID: 14640641 Genetically Targeted Chromophore-assisted Light Inactivation Nature Biotechnology. Dec, 2003 | Pubmed ID: 14625562 Imagining Imaging's Future Nature Reviews. Molecular Cell Biology. Sep, 2003 | Pubmed ID: 14587522 All-optical Histology Using Ultrashort Laser Pulses Neuron. Jul, 2003 | Pubmed ID: 12848930 A Genetically Encoded Fluorescent Reporter Reveals Oscillatory Phosphorylation by Protein Kinase C The Journal of Cell Biology. Jun, 2003 | Pubmed ID: 12782683 Detection of Calcium Transients in Drosophila Mushroom Body Neurons with Camgaroo Reporters The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2003 | Pubmed ID: 12514202 Overview of the Alliance for Cellular Signaling Nature. Dec, 2002 | Pubmed ID: 12478301 Creating New Fluorescent Probes for Cell Biology Nature Reviews. Molecular Cell Biology. Dec, 2002 | Pubmed ID: 12461557 A Monomeric Red Fluorescent Protein Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12060735 A New Form of Cerebellar Long-term Potentiation is Postsynaptic and Depends on Nitric Oxide but Not CAMP Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12048250 New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications Journal of the American Chemical Society. May, 2002 | Pubmed ID: 12022841 Partitioning of Lipid-modified Monomeric GFPs into Membrane Microdomains of Live Cells Science (New York, N.Y.). May, 2002 | Pubmed ID: 11988576 Multicolor and Electron Microscopic Imaging of Connexin Trafficking Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11964472 2009 Линдау лауреат Нобелевской премии собрания: Roger Y. Цяня, химии 2008 Roger Y. Tsien JoVE 1575 Editorial
2009 Линдау лауреат Нобелевской премии собрания: Roger Y. Цяня, химии 2008 Roger Y. Tsien JoVE 1575 Editorial