Autonomic Dysfunction, Vasomotor Rhinitis, and Extraesophageal Manifestations of Gastroesophageal Reflux

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Apr, 2002  |  Pubmed ID: 11997777

Several recent reports suggest there may be a relationship between chronic rhinitis and extraesophageal manifestations of gastroesophageal reflux (EER). It is hypothesized that this relationship is a result of autonomic nervous system (ANS) dysfunction.

A Modified End-to-side Method for Peripheral Nerve Repair: Large Epineurial Window Helicoid Technique Versus Small Epineurial Window Standard End-to-side Technique

The Journal of Hand Surgery. May, 2002  |  Pubmed ID: 12015724

This study evaluated 2 end-to-side nerve repair techniques for ability to induce nerve sprouting and muscular recovery. Twenty-four rats underwent identical surgeries. The helicoid method of neurorrhaphy was used on the left (large epineurial window) side and the standard end-to-side (small epineurial window) repair on the right side of each rat to repair the peroneal nerve. The helicoid configuration markedly increases the area from which axons can sprout into the recipient nerve. At 11 months after surgery, axons were counted in donor and recipient nerves, and muscle moist weight of the extensor digitorum longus (EDL) and tetanic force were measured. Muscle volume, tetanic force, and moist weight of EDL muscles were significantly higher on the left side (helicoid) than on the right (end-to-side). Histologic analysis and nerve axon counting of the recipient peroneal nerve showed significantly more regenerative nerves on the left than on the right. There were no significant differences between sites above and below the repair site in the donor tibial nerve in regard to mean number of nerve fibers. Helicoid nerve repair can entice more nerve fiber sprouts from the intact donor nerve, improve muscular recovery, and maintain donor nerve health.

Morphology of the Cricopharyngeal Muscle in Zenker and Control Specimens

The Annals of Otology, Rhinology, and Laryngology. Jul, 2002  |  Pubmed ID: 12126011

The cricopharyngeal muscle (CPM) is essential for normal deglutition. Pharyngeal dysphagia commonly results from impaired or uncoordinated CPM dilation. Dysfunction of the CPM has also been implicated in the genesis of Zenker's (pharyngoesophageal) diverticulum. Despite the CPM's significance, little is understood about its morphology. We studied CPM biopsy specimens from 20 patients with Zenker's diverticulum and from 5 fresh cadaver patients with detailed histologic techniques to include fiber size and shape and adenosine triphosphatase, reduced nicotinamide adenine dinucleotide, trichrome, succinate dehydrogenase, cytochrome C oxidase, periodic acid-Schiff reaction, oil red O, acid phosphatase, Congo red, crystal violet, and monoadenylate deaminase stains. The normal CPM has unique morphological characteristics, with some myofibers having staining properties that are a hybrid between striated muscle and muscle spindle. The variable orientation of the muscle fibers is also different from that of most other striated musculature. Of the 20 Zenker CPM specimens, 4 specimens did not reveal any significant differences from controls (2 of which had insufficient amounts of tissue for complete analysis). In the remaining 16 specimens, several abnormalities existed, including excessive size variation (16/16), grouping of atrophic fibers (9/16), target or targetoid formations (4/16), cores (2/16), and ragged red fibers (2/16). The final pathological pattern of the 16 specimens was neurogenic in 7, myopathic in 4, and mixed (with neurogenic predominance) in the remaining 5. Two specimens contained significant lymphocytic inflammatory infiltrates. We conclude that the unique neuromuscular function of the CPM in deglutition is likely due to its fiber orientation and the hybrid nature of some of the myofibers. Morphological disturbances of the CPM impair its dilation and may account for the development of Zenker's diverticulum. This disturbance is most often due to progressive denervation of the CPM.

Videofluoroscopic Swallow Studies in Unilateral Cricopharyngeal Dysfunction

The Laryngoscope. Jun, 2003  |  Pubmed ID: 12782808

Although the cricopharyngeus muscle is a ring-like structure, unilateral cricopharyngeal dysfunction can produce significant dysphagia. This entity has not been well described in the literature. The aims of the study were to identify the characteristic findings on videofluoroscopic swallow studies in patients with dysphagia secondary to unilateral cricopharyngeal dysfunction, to note the associated vagal nerve injury, and to evaluate patient outcomes following ipsilateral cricopharyngeal myotomy.

Evaluation of the Autonomic Nervous System

Physical Medicine and Rehabilitation Clinics of North America. May, 2003  |  Pubmed ID: 12795517

This article has reviewed the laboratory evaluation of autonomic disorders. Autonomic testing can be divided into the assessment of three functional domains: sudomotor (assessed best by the thermoregulatory sweat test or QSART), cardiovagal (assessed by the Valsalva ratio and heart rate response to deep breathing or standing up), and adrenergic (assessed by the blood pressure response to the Valsalva maneuver or head-upright tilt). Tables 2 and 3 summarize the test findings in a variety of clinical disorders affecting autonomic nervous system function.

Hereditary Neuropathies

Journal of Clinical Neuromuscular Disease. Dec, 2003  |  Pubmed ID: 19078724

The spectrum of hereditary neuropathies has evolved recently as a result of the exponential growth of genetic research. For the purpose of this review, we will use Charcot-Marie-Tooth (CMT), hereditary liability to pressure palsy (HNPP) and hereditary sensory and autonomic neuropathies (HSAN) to illustrate the current clinical and genetic approach to such neuropathies.

Muscle, Nerve, and Skin Biopsy

Neurologic Clinics. Aug, 2004  |  Pubmed ID: 15207875

The diagnostic approach to neuromuscular disorders begins with clinical evaluation and electromyographic examination. The histology of the muscle, nerve, and skin are the subsequent essential steps in establishing the diagnosis.

Autonomic Nervous System Evaluation in Allergic Rhinitis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Jan, 2007  |  Pubmed ID: 17210333

To evaluate the relationship between allergic rhinitis (AR) and autonomic nervous system (ANS) dysfunction.

CNS Blastomycosis in a Young Man Working in Fields After Hurricane Katrina

Neurology. May, 2007  |  Pubmed ID: 17502562

Myosin Heavy Chain Composition and Fiber Size of the Cricopharyngeus Muscle in Patients with Achalasia and Normal Subjects

The Annals of Otology, Rhinology, and Laryngology. Sep, 2007  |  Pubmed ID: 17926584

Cricopharyngeal achalasia (CA) can be defined as inadequate opening of the cricopharyngeus muscle (CPM) resulting in dysphagia. Myosin heavy chain (MHC) isoform fiber type composition and size are key determinants of muscle function. These parameters have not been described in CA. It is hypothesized that there is a difference between the MHC isoform composition of the CPM in patients with the clinical diagnosis of CA and that in normal subjects.

Refining the Sensory and Motor Ratunculus of the Rat Upper Extremity Using FMRI and Direct Nerve Stimulation

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Nov, 2007  |  Pubmed ID: 17969116

It is well understood that the different regions of the body have cortical representations in proportion to the degree of innervation. Our current understanding of the rat upper extremity has been enhanced using functional MRI (fMRI), but these studies are often limited to the rat forepaw. The purpose of this study is to describe a new technique that allows us to refine the sensory and motor representations in the cerebral cortex by surgically implanting electrodes on the major nerves of the rat upper extremity and providing direct electrical nerve stimulation while acquiring fMRI images. This technique was used to stimulate the ulnar, median, radial, and musculocutaneous nerves in the rat upper extremity using four different stimulation sequences that varied in frequency (5 Hz vs. 10 Hz) and current (0.5 mA vs. 1.0 mA). A distinct pattern of cortical activation was found for each nerve. The higher stimulation current resulted in a dramatic increase in the level of cortical activation. The higher stimulation frequency resulted in both increases and attenuation of cortical activation in different regions of the brain, depending on which nerve was stimulated.

Cortical Brain Mapping of Peripheral Nerves Using Functional Magnetic Resonance Imaging in a Rodent Model

Journal of Reconstructive Microsurgery. Nov, 2008  |  Pubmed ID: 18924070

The regions of the body have cortical and subcortical representation in proportion to their degree of innervation. The rat forepaw has been studied extensively in recent years using functional magnetic resonance imaging (fMRI), typically by stimulation using electrodes directly inserted into the skin of the forepaw. Here we stimulate the nerve directly using surgically implanted electrodes. A major distinction is that stimulation of the skin of the forepaw is mostly sensory, whereas direct nerve stimulation reveals not only the sensory system but also deep brain structures associated with motor activity. In this article, we seek to define both the motor and sensory cortical and subcortical representations associated with the four major nerves of the rodent upper extremity. We electrically stimulated each nerve (median, ulnar, radial, and musculocutaneous) during fMRI acquisition using a 9.4-T Bruker scanner (Bruker BioSpin, Billerica, MA). A current level of 0.5 to 1.0 mA and a frequency of 5 Hz were used while keeping the duration constant. A distinct pattern of cortical activation was found for each nerve that can be correlated with known sensorimotor afferent and efferent pathways to the rat forepaw. This direct nerve stimulation rat model can provide insight into peripheral nerve injury.

The Correlation Between Calcium Absorption and Electrophysiological Recovery in Crushed Rat Peripheral Nerves

Microsurgery. 2010  |  Pubmed ID: 19790186

The correlation between calcium ion (Ca2+) concentration and electrophysiological recovery in crushed peripheral nerves has not been studied. Observing and quantifying the Ca2+ intensity in live normal and crushed peripheral nerves was performed using a novel microfine tearing technique and Calcium Green-1 Acetoxymethyl ester stain, a fluorescent Ca2+ indicator. Ca2+ was shown to be homogeneously distributed in the myelinated sheaths. After a crush injury, there was significant stasis in the injured zone and the portion distal to the injury. The Ca2+ has been almost completely absorbed after 24 weeks in the injured nerve to be similar to the controls. The process of the calcium absorption was correlated with the Compound Muscle Action Potential recovery process of the injured nerves. This correlation was statistically significant (r = -0.81, P < 0.05). The better understanding of this process will help us to improve nerve regeneration after peripheral nerve injury.

A New Noninvasive Method for Determination of Laryngeal Sensory Function

The Laryngoscope. Jan, 2011  |  Pubmed ID: 21120827

We report a new surface technique for studying sensory conduction in the superior laryngeal nerve (SLN).

Helicoid End-to-side and Oblique Attachment Technique in Repair of the Musculocutaneous Nerve Injury with the Phrenic Nerve As a Donor: an Experimental Study in Rats

Microsurgery. Feb, 2011  |  Pubmed ID: 21268106

The purpose of this study was to identify if a modified end-to-side repair can achieve equal results of nerve regeneration compared to an end-to-end repair using donor phrenic nerves in repair of the musculocutaneous nerve and also pulmonary protection. Eighteen rats were divided into three groups of six each comparing two nerve graft techniques: helicoid end-to-side plus distal oblique repair vs. traditional end-to-end repair, using a donor phrenic nerve. The saphenous nerve was used as a graft between the phrenic nerve and the musculocutaneous nerve. The third group was used as control; the musculocutaneous nerve was transected without any repair. Three months postoperatively, electrophysiology, tetanic force, moist muscle weight, histology, nerve fiber counting, and chest X-ray were evaluated. All results have shown that this modified end-to-side repair was superior to the end-to-end repair. The former did not compromise the diaphragm function, but the latter showed an elevation of the diaphragm. Little recovery was seen in the third group. The conclusion is that this modified end-to-side repair can replace the traditional end-to-end repair using donor phrenic nerves with better results of nerve regeneration without diaphragm compromise.