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In JoVE (1)
Other Publications (1)
Articles by Sara Dolatshahi Pirooz in JoVE
Measurement of γHV68 Infection in Mice
Sara Dolatshahi Pirooz, Joo-Hyung Lee, Zhen Zhao, Duojiao Ni, Soohwan Oh, Chengyu Liang
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles
γ-Herpesviruses (γ-HVs) establish life-long persistency in their host. Infection of mice with γ-HV68 provides a genetically tractable in vivo model for the characterization of the lifecycle/pathogenesis of γHVs. This protocol describes the detection and quantitation of γHV68 infection at acute and latent stages following infection by plaque-forming, infectious center, and qPCR assays.
Other articles by Sara Dolatshahi Pirooz on PubMed
Autophagy. Feb, 2011 | Pubmed ID: 21099349
Bcl-2, originally identified as a universal inhibitor of apoptotic cell death, has since been implicated in suppressing autophagy, the cell's quality control mechanism. Our recent study demonstrates that the anti-autophagic aspect of Bcl-2 can function as a promoter of oncogenic growth, independently of its role in apoptosis signaling. It is likely that the increase in Bcl-2 often seen in breast and other cancers might render cells error-prone by blunting autophagy, while concomitantly keeping damaged cells alive. The outcome of such a 'double hit' of Bcl-2 may synergistically promote tumor growth and increase the chance of cancer development and drug resistance.