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Articles by Sarah E. Chapman in JoVE

 JoVE Clinical and Translational Medicine

تجزئة والقياس من وحدات تخزين الدهون في الفئران نماذج السمنة عن طريق الأشعة السينية التصوير المقطعي


JoVE 3680 4/04/2012

1Carestream Molecular Imaging, 2Department of Chemistry and Biochemistry, University of Notre Dame, 3Freimann Life Science Center, University of Notre Dame, 4Research and Development, Oncovision, GEM-Imaging S.A.

ويجري بصورة روتينية الدهون تحليل المحتوى في دراسات استخدام نماذج البدانة الفئران. الأساليب المستجدة في حيوان صغير CT التصوير والتحليل وتقديم لمزيد من التفاصيل الغنية طولية تحليل محتوى الدهون. الخطوة هنا بالتفصيل ونحن من خلال إجراءات لتنفيذ خطوة صغيرة حيوان CT التصوير والتحليل والتصور.

 JoVE General

3D الطباعة الأشعة السينية ما قبل السريرية البيانات المحسوبة تصوير الشعاعي الطبقي مجموعات


JoVE 50250 3/22/2013

1Department of Chemistry and Biochemistry, University of Notre Dame, 2Freimann Life Science Center, University of Notre Dame, 3Department of Biological Sciences, University of Notre Dame, 4Notre Dame Integrated Imaging Facility, University of Notre Dame, 5MakerBot Industries LLC, 6Departments of Biological Sciences, Aerospace and Mechanical Engineering, and Anthropology, University of Notre Dame, 7Harper Cancer Research Institute, University of Notre Dame

باستخدام البثق البلاستيك الحديثة وتقنيات الطباعة، أصبح من الممكن الآن بسرعة وبتكاليف زهيدة إنتاج النماذج الفيزيائية للبيانات الأشعة السينية CT المتخذة في المختبر. طباعة ثلاثية الأبعاد للبيانات تصوير الشعاعي الطبقي هو التصور قوية، والبحوث، وأداة تعليمية يمكن الآن الوصول إليها من قبل المجتمع التصوير قبل السريرية.

Other articles by Sarah E. Chapman on PubMed

In Vivo Cell Death Mediated by Synthetic Ion Channels

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Dual Tracer Imaging of SPECT and PET Probes in Living Mice Using a Sequential Protocol

Over the past 20 years, multimodal imaging strategies have motivated the fusion of Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) scans with an X-ray computed tomography (CT) image to provide anatomical information, as well as a framework with which molecular and functional images may be co-registered. Recently, pre-clinical nuclear imaging technology has evolved to capture multiple SPECT or multiple PET tracers to further enhance the information content gathered within an imaging experiment. However, the use of SPECT and PET probes together, in the same animal, has remained a challenge. Here we describe a straightforward method using an integrated trimodal imaging system and a sequential dosing/acquisition protocol to achieve dual tracer imaging with (99m)Tc and (18)F isotopes, along with anatomical CT, on an individual specimen. Dosing and imaging is completed so that minimal animal manipulations are required, full trimodal fusion is conserved, and tracer crosstalk including down-scatter of the PET tracer in SPECT mode is avoided. This technique will enhance the ability of preclinical researchers to detect multiple disease targets and perform functional, molecular, and anatomical imaging on individual specimens to increase the information content gathered within longitudinal in vivo studies.

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