JoVE Neuroscience
Gregory J. Gage1, Colin R. Stoetzner1, Thomas Richner2, Sarah K. Brodnick2, Justin C. Williams2, Daryl R. Kipke1,3
1Biomedical Engineering, University of Michigan, 2Biomedical Engineering, University of Wisconsin-Madison, 3NeuroNexus Technologies
Nós fornecemos informações úteis para os cirurgiões que estão aprendendo o processo de implantação de eletrodos de registro crônicas neurais. Técnicas para sistemas de eléctrodos de ambos penetrantes e de superfície são descritos em um modelo animal de roedores.
JoVE Neuroscience
Seth J. Wilks1, Tom J. Richner2, Sarah K. Brodnick2, Daryl R. Kipke3, Justin C. Williams2, Kevin J. Otto1,4
1Weldon School of Biomedical Engineering, Purdue University, 2Biomedical Engineering, University of Wisconsin-Madison, 3Biomedical Engineering, University of Michigan, 4Department of Biological Sciences, Purdue University
A interface eletrodo-tecido de eletrodos de registro neurais podem ser caracterizados com espectroscopia de impedância elétrica (EIS) e voltametria cíclica (CV). Aplicação de capacidade de gravação de tensão de polarização alterações das propriedades eletroquímicas da interface eletrodo-tecido e pode melhorar. Tensão de polarização, EIS, CV, e gravações neurais são complementares.
Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS). Oct, 2011 | Pubmed ID: 22208124
Over the past decade, electrocorticography (ECoG) has been used for a wide set of clinical and experimental applications. Recently, there have been efforts in the clinic to adapt traditional ECoG arrays to include smaller recording contacts and spacing. These devices, which may be collectively called "micro-ECoG" arrays, are loosely defined as intercranial devices that record brain electrical activity on the sub-millimeter scale. An extensible 3D-platform of thin film flexible micro-scale ECoG arrays appropriate for Brain-Computer Interface (BCI) application, as well as monitoring epileptic activity, is presented. The designs utilize flexible film electrodes to keep the array in place without applying significant pressure to the brain and to enable radial subcranial deployment of multiple electrodes from a single craniotomy. Deployment techniques were tested in non-human primates, and stimulus-evoked activity and spontaneous epileptic activity were recorded. Further tests in BCI and epilepsy applications will make the electrode platform ready for initial human testing.