Silvia Deaglio Department of Medical Sciences, Human Genetics Foundation (HuGeF) University of Turin Biography Publications Institution JoVE Articles Silvia Deaglio has not added a biography. If you are Silvia Deaglio and would like to personalize this page please email our Author Liaison for assistance. Publications The Genetics of Nodal Marginal Zone Lymphoma Blood. Jun, 2016 | Pubmed ID: 27335277 MiR-214 and MiR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer Cancer Research. Jun, 2016 | Pubmed ID: 27328731 Involvement of the P2X7-NLRP3 Axis in Leukemic Cell Proliferation and Death Scientific Reports. 2016 | Pubmed ID: 27221966 SLAMF1 Regulation of Chemotaxis and Autophagy Determines CLL Patient Response The Journal of Clinical Investigation. Jan, 2016 | Pubmed ID: 26619119 Identification of a New Subclass of ALK-negative ALCL Expressing Aberrant Levels of ERBB4 Transcripts Blood. Jan, 2016 | Pubmed ID: 26463425 Lenalidomide Interferes with Tumor-promoting Properties of Nurse-like Cells in Chronic Lymphocytic Leukemia Haematologica. Feb, 2015 | Pubmed ID: 25398834 Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Promotes M2 Macrophage Polarization in Chronic Lymphocytic Leukemia Blood. Jan, 2015 | Pubmed ID: 25368373 Anti-CD44 MAb for the Treatment of B-cell Chronic Lymphocytic Leukemia and Other Hematological Malignancies: Evaluation of WO2013063498 Expert Opinion on Therapeutic Patents. Jul, 2014 | Pubmed ID: 24798704 HLA-G is a Component of the Chronic Lymphocytic Leukemia Escape Repertoire to Generate Immune Suppression: Impact of the HLA-G 14 Base Pair (rs66554220) Polymorphism Haematologica. May, 2014 | Pubmed ID: 24362551 Complementary and Alternative Medicine Use in Patients with Chronic Lymphocytic Leukemia: an Italian Multicentric Survey Leukemia & Lymphoma. Apr, 2014 | Pubmed ID: 23829282 Multiple Metamorphoses of CD38 from Prognostic Marker to Disease Modifier to Therapeutic Target in Chronic Lymphocytic Leukemia Current Topics in Medicinal Chemistry. 2013 | Pubmed ID: 24171772 Rs2072135, a Low-penetrance Variant for Chronic Lymphocytic Leukaemia? British Journal of Haematology. Jul, 2013 | Pubmed ID: 23668599 The Monocytic Population in Chronic Lymphocytic Leukemia Shows Altered Composition and Deregulation of Genes Involved in Phagocytosis and Inflammation Haematologica. Jul, 2013 | Pubmed ID: 23349302 The PD-1/PD-L1 Axis Contributes to T-cell Dysfunction in Chronic Lymphocytic Leukemia Haematologica. Jun, 2013 | Pubmed ID: 23300177 Biological Functions of Ecto-enzymes in Regulating Extracellular Adenosine Levels in Neoplastic and Inflammatory Disease States Journal of Molecular Medicine (Berlin, Germany). Feb, 2013 | Pubmed ID: 23292173 Targeting the Microenvironment in Chronic Lymphocytic Leukemia Offers Novel Therapeutic Options Cancer Letters. Jan, 2013 | Pubmed ID: 22910767 Chronic Lymphocytic Leukemia After Chronic Myeloid Leukemia in the Same Patient: Two Different Genomic Events and a Common Treatment? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2012 | Pubmed ID: 23008321 Regulatory T-cells in Chronic Lymphocytic Leukemia and Autoimmune Diseases Mediterranean Journal of Hematology and Infectious Diseases. 2012 | Pubmed ID: 22973497 The Coding Genome of Splenic Marginal Zone Lymphoma: Activation of NOTCH2 and Other Pathways Regulating Marginal Zone Development The Journal of Experimental Medicine. Aug, 2012 | Pubmed ID: 22891273 Different Aquaporin-4 Expression in Glioblastoma Multiforme Patients with and Without Seizures Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22714714 Microenvironmental Interactions in Chronic Lymphocytic Leukemia: Hints for Pathogenesis and Identification of Targets for Rational Therapy Current Pharmaceutical Design. 2012 | Pubmed ID: 22591383 A Shorter Time to the First Treatment May Be Predicted by the Absolute Number of Regulatory T-cells in Patients with Rai Stage 0 Chronic Lymphocytic Leukemia American Journal of Hematology. Jun, 2012 | Pubmed ID: 22460620 Disruption of BIRC3 Associates with Fludarabine Chemorefractoriness in TP53 Wild-type Chronic Lymphocytic Leukemia Blood. Mar, 2012 | Pubmed ID: 22308293 Physical Contact with Endothelial Cells Through β1- and β2- Integrins Rescues Chronic Lymphocytic Leukemia Cells from Spontaneous and Drug-induced Apoptosis and Induces a Peculiar Gene Expression Profile in Leukemic Cells Haematologica. Jun, 2012 | Pubmed ID: 22207686 Mutations of NOTCH1 Are an Independent Predictor of Survival in Chronic Lymphocytic Leukemia Blood. Jan, 2012 | Pubmed ID: 22077063 Mutations of the SF3B1 Splicing Factor in Chronic Lymphocytic Leukemia: Association with Progression and Fludarabine-refractoriness Blood. Dec, 2011 | Pubmed ID: 22039264 CD73-generated Extracellular Adenosine in Chronic Lymphocytic Leukemia Creates Local Conditions Counteracting Drug-induced Cell Death Blood. Dec, 2011 | Pubmed ID: 21998208 Alteration of BIRC3 and Multiple Other NF-κB Pathway Genes in Splenic Marginal Zone Lymphoma Blood. Nov, 2011 | Pubmed ID: 21881048 CD38 and Chronic Lymphocytic Leukemia: a Decade Later Blood. Sep, 2011 | Pubmed ID: 21765022 Ectonucleotidases As Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity Advances in Pharmacology (San Diego, Calif.). 2011 | Pubmed ID: 21586363 Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells Through Activation of the P53/miR-34a/SIRT1 Tumor Suppressor Network Cancer Research. Jul, 2011 | Pubmed ID: 21565980 Common Genetic Variation at 15q25.2 Impacts on Chronic Lymphocytic Leukaemia Risk British Journal of Haematology. Jul, 2011 | Pubmed ID: 21554262 A Highly Immunogenic Recombinant and Truncated Protein of the Secreted Aspartic Proteases Family (rSap2t) of Candida Albicans As a Mucosal Anticandidal Vaccine FEMS Immunology and Medical Microbiology. Jul, 2011 | Pubmed ID: 21535228 NAD+-metabolizing Ecto-enzymes Shape Tumor-host Interactions: the Chronic Lymphocytic Leukemia Model FEBS Letters. Jun, 2011 | Pubmed ID: 21514298 Oct-4+/Tenascin C+ Neuroblastoma Cells Serve As Progenitors of Tumor-derived Endothelial Cells Cell Research. Oct, 2011 | Pubmed ID: 21403679 A Variant of the LRP4 Gene Affects the Risk of Chronic Lymphocytic Leukaemia Transformation to Richter Syndrome British Journal of Haematology. Feb, 2011 | Pubmed ID: 21121903 Variable Impact of CD39 in Experimental Murine Colitis Digestive Diseases and Sciences. May, 2011 | Pubmed ID: 20936356 Regulatory T-cell Number is Increased in Chronic Lymphocytic Leukemia Patients and Correlates with Progressive Disease Leukemia Research. Mar, 2011 | Pubmed ID: 20880586 Multicentre Validation of a Prognostic Index for Overall Survival in Chronic Lymphocytic Leukaemia Hematological Oncology. Jun, 2011 | Pubmed ID: 20669154 Chronic Lymphocytic Leukemia-associated Immune Thrombocytopenia Treated with Rituximab: a Retrospective Study of 21 Patients European Journal of Haematology. Dec, 2010 | Pubmed ID: 20846302 CD38 As a Molecular Compass Guiding Topographical Decisions of Chronic Lymphocytic Leukemia Cells Seminars in Cancer Biology. Dec, 2010 | Pubmed ID: 20817095 The Hidden Life of NAD+-consuming Ectoenzymes in the Endocrine System Journal of Molecular Endocrinology. Oct, 2010 | Pubmed ID: 20660167 Transferrin Receptor 2 is Frequently and Highly Expressed in Glioblastomas Translational Oncology. Apr, 2010 | Pubmed ID: 20360937 Monocytes/macrophages but Not T Lymphocytes Are the Major Targets of the CCL3/CCL4 Chemokines Produced by CD38(+)CD49d(+) Chronic Lymphocytic Leukaemia Cells British Journal of Haematology. Jul, 2010 | Pubmed ID: 20346010 Genetic Modification of Primary Chronic Lymphocytic Leukemia Cells with a Lentivirus Expressing CD38 Haematologica. Mar, 2010 | Pubmed ID: 20207849 CD38/CD31 Interactions Activate Genetic Pathways Leading to Proliferation and Migration in Chronic Lymphocytic Leukemia Cells Molecular Medicine (Cambridge, Mass.). Mar, 2010 | Pubmed ID: 19956559 TfR2 Expression in Human Colon Carcinomas Blood Cells, Molecules & Diseases. Nov-Dec, 2009 | Pubmed ID: 19729324 Intrinsic and Extrinsic Factors Influencing the Clinical Course of B-cell Chronic Lymphocytic Leukemia: Prognostic Markers with Pathogenetic Relevance Journal of Translational Medicine. 2009 | Pubmed ID: 19715592 Stereotyped B-cell Receptor is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 19509140 Chronic Lymphocytic Leukemia Microenvironment: Shifting the Balance from Apoptosis to Proliferation Haematologica. Jun, 2009 | Pubmed ID: 19483151 CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival Cancer Research. May, 2009 | Pubmed ID: 19383907 CD38 and CD157 Ectoenzymes Mark Cell Subsets in the Human Corneal Limbus Molecular Medicine (Cambridge, Mass.). Mar-Apr, 2009 | Pubmed ID: 19052657 Regulation of Transferrin Receptor 2 in Human Cancer Cell Lines Blood Cells, Molecules & Diseases. Jan-Feb, 2009 | Pubmed ID: 19019709 Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology Physiological Reviews. Jul, 2008 | Pubmed ID: 18626062 CD38 Gene Polymorphism and Chronic Lymphocytic Leukemia: a Role in Transformation to Richter Syndrome? Blood. Jun, 2008 | Pubmed ID: 18424664 CD38 at the Junction Between Prognostic Marker and Therapeutic Target Trends in Molecular Medicine. May, 2008 | Pubmed ID: 18403265 CD39 and Control of Cellular Immune Responses Purinergic Signalling. Mar, 2007 | Pubmed ID: 18404431 Regulation of CD38 in Proliferating Chronic Lymphocytic Leukemia Cells Stimulated with CD154 and Interleukin-4 Haematologica. Oct, 2007 | Pubmed ID: 18024373 CD38 and ZAP-70 Are Functionally Linked and Mark CLL Cells with High Migratory Potential Blood. Dec, 2007 | Pubmed ID: 17699742 Prognostic Significance of Combined Analysis of ZAP-70 and CD38 in Chronic Lymphocytic Leukemia American Journal of Hematology. Sep, 2007 | Pubmed ID: 17534928 Adenosine Generation Catalyzed by CD39 and CD73 Expressed on Regulatory T Cells Mediates Immune Suppression The Journal of Experimental Medicine. Jun, 2007 | Pubmed ID: 17502665 Transferrin Receptor 2 is Frequently Expressed in Human Cancer Cell Lines Blood Cells, Molecules & Diseases. Jul-Aug, 2007 | Pubmed ID: 17428703 CD38/CD19: a Lipid Raft-dependent Signaling Complex in Human B Cells Blood. Jun, 2007 | Pubmed ID: 17327405 The CD38/CD157 Mammalian Gene Family: An Evolutionary Paradigm for Other Leukocyte Surface Enzymes Purinergic Signalling. Jun, 2006 | Pubmed ID: 18404481 The CD38 Ectoenzyme Family: Advances in Basic Science and Clinical Practice Molecular Medicine (Cambridge, Mass.). Nov-Dec, 2006 | Pubmed ID: 17380202 CD38 and CD157 As Receptors of the Immune System: a Bridge Between Innate and Adaptive Immunity Molecular Medicine (Cambridge, Mass.). Nov-Dec, 2006 | Pubmed ID: 17380201 TfR2 Localizes in Lipid Raft Domains and is Released in Exosomes to Activate Signal Transduction Along the MAPK Pathway Journal of Cell Science. Nov, 2006 | Pubmed ID: 17046995 In-tandem Insight from Basic Science Combined with Clinical Research: CD38 As Both Marker and Key Component of the Pathogenetic Network Underlying Chronic Lymphocytic Leukemia Blood. Aug, 2006 | Pubmed ID: 16621959 CD38 Orchestrates Migration, Survival, and Th1 Immune Response of Human Mature Dendritic Cells Blood. Mar, 2006 | Pubmed ID: 16293598 Immunodetection of Anti-MAG IgM Antibody by Cross-reactivity to LA-N-1 Neuroblastoma Cells Journal of Neuroimmunology. Apr, 2005 | Pubmed ID: 15748946 CD38 and CD100 Lead a Network of Surface Receptors Relaying Positive Signals for B-CLL Growth and Survival Blood. Apr, 2005 | Pubmed ID: 15613544 Transferrin Receptor 2 Protein is Not Expressed in Normal Erythroid Cells The Biochemical Journal. Aug, 2004 | Pubmed ID: 15084147 Death of T Cell Precursors in the Human Thymus: a Role for CD38 International Immunology. Sep, 2003 | Pubmed ID: 12917263 CD38 is a Signaling Molecule in B-cell Chronic Lymphocytic Leukemia Cells Blood. Sep, 2003 | Pubmed ID: 12763926 Role of CD31/platelet Endothelial Cell Adhesion Molecule-1 Expression in in Vitro and in Vivo Growth and Differentiation of Human Breast Cancer Cells The American Journal of Pathology. Apr, 2003 | Pubmed ID: 12651608 Simultaneous Expression of CD38 and Its Ligand CD31 by Chronic Lymphocytic Leukemia B-cells: Anecdotal Observation or Pathogenetic Hypothesis for the Clinical Outcome? Haematologica. Mar, 2003 | Pubmed ID: 12651280 Human CD38 Interferes with HIV-1 Fusion Through a Sequence Homologous to the V3 Loop of the Viral Envelope Glycoprotein Gp120 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2003 | Pubmed ID: 12551845 Expression of Ribosomal and Translation-associated Genes is Correlated with a Favorable Clinical Course in Chronic Lymphocytic Leukemia Blood. Apr, 2003 | Pubmed ID: 12456497 CD38 Ligation Plays a Direct Role in the Induction of IL-1beta, IL-6, and IL-10 Secretion in Resting Human Monocytes Cellular Immunology. Nov, 2002 | Pubmed ID: 12718937 Structural, Functional, and Tissue Distribution Analysis of Human Transferrin Receptor-2 by Murine Monoclonal Antibodies and a Polyclonal Antiserum Blood. Nov, 2002 | Pubmed ID: 12393650 Arsenic Trioxide and Breast Cancer: Analysis of the Apoptotic, Differentiative and Immunomodulatory Effects Breast Cancer Research and Treatment. May, 2002 | Pubmed ID: 12083632 Oxytocin is a Growth Factor for Kaposi's Sarcoma Cells: Evidence of Endocrine-immunological Cross-talk Cancer Research. Apr, 2002 | Pubmed ID: 11956104 Human CD38 and CD16 Are Functionally Dependent and Physically Associated in Natural Killer Cells Blood. Apr, 2002 | Pubmed ID: 11895784 Peripheral Blood CD38 Expression Predicts Time to Progression in B-cell Chronic Lymphocytic Leukemia After First-line Therapy with High-dose Chlorambucil Haematologica. Feb, 2002 | Pubmed ID: 11836173 HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells Sara Serra1, Silvia Deaglio1 1Department of Medical Sciences, Human Genetics Foundation (HuGeF), University of Turin JoVE 54124 Chemistry
HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells Sara Serra1, Silvia Deaglio1 1Department of Medical Sciences, Human Genetics Foundation (HuGeF), University of Turin JoVE 54124 Chemistry