In JoVE (1)

Other Publications (7)

Articles by Simon Michael Würth in JoVE

Other articles by Simon Michael Würth on PubMed

Pharmacokinetics and Safety of Valaciclovir in Children with Epstein-Barr Virus Illness

Drugs in R&D. 2002  |  Pubmed ID: 12516939

Valaciclovir has in vitro activity against Epstein-Barr virus (EBV) and, because of improved absorption with higher achievable serum concentrations, may be more effective than aciclovir in the treatment of EBV. No studies to date have evaluated the efficacy, safety or proper dosing of valaciclovir in children for the treatment of EBV infection. The objectives of this study were to determine the pharmacokinetics and safety of valaciclovir tablets and suspension in children with EBV illness.

Congenital Absence of the 5th Digital Ray and Its Proximal Segmental Structures

American Journal of Perinatology. Jan, 2003  |  Pubmed ID: 12638075

Limb reduction anomalies involving digits or parts of limbs are not uncommon. Most cases take the form of terminal transverse absence defects involving hypoplasia or aplasia of all structures distal to a particular level on a limb with relative preservation of the more proximal tissues. Longitudinal absence defects are a more rare form of limb reduction anomalies. Structures within one or more digital rays are typically involved. More proximal segmental tissues may also be affected with the most serious cases resulting in absence of the radius or ulna. We report a case of isolated, longitudinal absence of the 5th finger and its corresponding proximal segmental structures in a newborn infant. The embryology of limb development and possible etiologies for skeletal absence defects are summarized.

Occurrence of Epstein-Barr Virus Illness in Children Diagnosed with Group A Streptococcal Pharyngitis

Clinical Pediatrics. Jun, 2003  |  Pubmed ID: 12862344

Epstein-Barr virus mononucleosis and group A streptococcal pharyngitis are acute infectious processes similar in both their clinical manifestations. Coinfections may occur and be a direct result of a synergistic effect on inflamed pharyngeal and tonsillar tissue. It was our observation that a population of children diagnosed with group A streptococcal pharyngitis and not responding to appropriate antimicrobial therapy had Epstein-Barr virus illness.

The Effect of Amoxicillin-clavulanate, Cefixime and Azithromycin on Normal Throat Flora in Children with Group A Streptococcal Pharyngitis

Clinical Pediatrics. Jun, 2003  |  Pubmed ID: 12862350

Cutaneous Larva Migrans

Pediatric Emergency Care. Oct, 2003  |  Pubmed ID: 14578837

Cutaneous larva migrans is occasionally seen in pediatric emergency outpatient care settings. It results from infestation of hookworm larvae into the epidermis. The infestation is self-limited but may produce severe discomfort. The diagnosis relies entirely on clinical findings. Laboratory findings only support the clinical diagnosis but do not confirm it. Treatment is typically with topical thiabendazole, but oral thiabendazole may be indicated in severe cases.

Changes in Newborn Bathing Practices May Increase the Risk for Omphalitis

Clinical Pediatrics. Oct, 2004  |  Pubmed ID: 15494885

Aseptic cord care, in conjunction with antibacterial skin care, has reduced the incidence of omphalitis specifically caused by Staphylococcus aureus. However, this practice has resulted in the emergence of resistant organisms that may pose a greater risk for newborn infections. Subsequently, many institutions have changed to dry cord care and nonantiseptic whole-body baths, a practice that has not been adequately studied to determine potential infectious risks. Three cases of omphalitis occurring after an institutional change to nonantiseptic whole-body baths are presented. Clinical diagnosis and treatment of omphalitis are reviewed. Recommendations for surveillance of omphalitis are offered.

Immunogenicity and Safety of Human Papillomavirus-16/18 AS04-adjuvanted Vaccine Coadministered with Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine And/or Meningococcal Conjugate Vaccine to Healthy Girls 11 to 18 Years of Age: Results from a Randomized Open Trial

The Pediatric Infectious Disease Journal. Dec, 2011  |  Pubmed ID: 21817954

A combined immunization strategy for administration of human papillomavirus (HPV) vaccine with other routine vaccines may lead to better compliance. Reactions and immunologic interference with concomitantly administered vaccines are unpredictable, necessitating clinical evaluation.

simple hit counter