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In JoVE (2)
- Murine Bioluminescent Hepatic Tumour Model
- Ex Vivo Culture of Patient Tissue & Examination of Gene Delivery
Other Publications (1)
Articles by Slawomir Salwa in JoVE
Murine Bioluminescent Hepatic Tumour Model
Simon Rajendran1, Slawomir Salwa1, Xuefeng Gao2, Sabin Tabirca2, Deirdre O'Hanlon3, Gerald C. O'Sullivan1, Mark Tangney1
1Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr. Laboratory, University College Cork, 2Department of Computer Science, University College Cork, 3South Infirmary Victoria University Hospital
This article describes a procedure for the induction of orthotopic bioluminescent liver tumours in mice, and subsequent analysis of tumour growth confined to the liver using live whole body luminescence imaging.
Ex Vivo Culture of Patient Tissue & Examination of Gene Delivery
Simon Rajendran1, Slawomir Salwa1, Xuefeng Gao2, Sabin Tabirca2, Deirdre O'Hanlon2, Gerald C. O'Sullivan1, Mark Tangney1
1Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr. Laboratory, University College Cork, 2Department of Computer Science, University College Cork
This article describes the culture of patient tissue slices for gene delivery studies and subsequent analysis of gene expression using IVIS bioluminescence imaging.
Other articles by Slawomir Salwa on PubMed
Electrochemotherapy As an Adjunct or Alternative to Other Treatments for Unresectable or In-transit Melanoma
Expert Review of Anticancer Therapy. Nov, 2009 | Pubmed ID: 19895245
Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions are not suitable for surgical resection and who have exhausted all other treatment modalities. ECT combines electroporation of tumor cells with the administration either of intravenous or intratumoral antineoplastic drugs, such as bleomycin or cisplatin. The cell membranes are thus rendered permeant to these impermeant hydrophilic drugs with a several hundred-fold increase in intracellular delivery and cytotoxicity. ECT is an effective treatment in the palliative management of unresectable recurrent disease with overall objective response rates of approximately 80-90%. ECT technology continues to evolve allowing application to deeper lesions. By combining ECT with tumor-specific immunostimulating approaches, such as perilesional IL-2, CpG oligonucleotides or prior immunogene therapy, there is a promise of both local and systemic control of this disease.