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In JoVE (1)
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Articles by Sonali Chaturvedi in JoVE
JoVE Immunology and Infection
Eenvoudige en robuuste In vivo En In vitro Aanpak voor het bestuderen van Virus Vergadering
1Department of Plant Pathology and Microbiology, University of California, Riverside, 2Department of Bioengineering, University of California, Riverside
Een eenvoudige, efficiënte en robuuste manier om de levering van meerdere virale componenten synchroniseren met plantencellen via
Other articles by Sonali Chaturvedi on PubMed
Evaluation of Gastric Tolerability, Antinociceptive and Antiinflammatory Activity of Combination NSAIDs in Rats
Non-steroidal antiinflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in clinical practice. Presently, several varieties of fixed dose combinations (FDCs) of NSAIDs are available over the counter and are being prescribed too. There is paucity of literature regarding comparative efficacy of these combinations against their individual component. Various clinical studies have documented increased incidence of gastric ulcerations with usage of more than one NSAID simultaneously.
Packaging and Structural Phenotype of Brome Mosaic Virus Capsid Protein with Altered N-terminal β-hexamer Structure
The first 45 amino acid region of brome mosaic virus (BMV) capsid protein (CP) contains RNA binding and structural domains that are implicated in the assembly of infectious virions. One such important structural domain encompassing amino acids 28QPVIV32, highly conserved between BMV and cowpea chlorotic mottle virus (CCMV), exhibits a β-hexamer structure. In this study we report that alteration of the β-hexamer structure by mutating 28QPVIV32 to 28AAAAA32 had no effect either on symptom phenotype, local and systemic movement in Chenopodium quinoa and RNA profile of in vivo assembled virions. However, sensitivity to RNase and assembly phenotypes distinguished virions assembled with CP subunits having β-hexamer from those of wild type. A comparison of 3-D models obtained by cryo electron microscopy revealed overall similar structural features for wild type and mutant virions, with small but significant differences near the 3-fold axes of symmetry.
