JoVE Neuroscience
Jeffrey W. Grimm, Jesse Barnes, Kindsey North, Stefan Collins, Rachel Weber
Department of Psychology and Program in Behavioral Neuroscience, Western Washington University
Responding for food or drug-paired cues increases over the course of a period of abstinence and this may relate to an increased susceptibility to relapse behaviors. Here we detail a procedure for evaluating this "incubation of craving" in rats that have self-administered sucrose.
Psychopharmacology. Jul, 2011 | Pubmed ID: 21318562
Conditioned cues can elicit relapse to drug- and food-seeking behavior over prolonged periods of abstinence. If seeking behavior depends on mesolimbic dopamine D1 receptors, blocking these receptors should reduce seeking behavior.