Interpreting Google Flu Trends Data for Pandemic H1N1 Influenza: the New Zealand Experience

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 2009  |  Pubmed ID: 19941777

For the period of the spread of pandemic H1N1 influenza in New Zealand during 2009, we compared results from Google Flu Trends with data from existing surveillance systems. The patterns from Google Flu Trends were closely aligned with (peaking a week before and a week after) two independent national surveillance systems for influenza-like illness (ILI) cases. It was much less congruent with (delayed by three weeks) data from ILI-related calls to a national free-phone Healthline and with media coverage of pandemic influenza. Some patterns were unique to Google Flu Trends and may not have reflected the actual ILI burden in the community. Overall, Google Flu Trends appears to provide a useful free surveillance system but it should probably be seen as supplementary rather than as an alternative.

Character Disposition and Behavior Type: Influences of Valence on Preschool Children's Social Judgments

The Journal of Genetic Psychology. Dec, 2009  |  Pubmed ID: 20034187

The authors studied the influences of valence information on preschool children's (n = 47) moral (good or bad), liking (liked or disliked by a friend), and consequence-of-behavior (reward or punishment) judgments. The authors presented 8 scenarios describing the behavior valence, positive valence (help, share), negative valence (verbal insult, physical aggression), and disposition valence (nice or mean) of characters in social interaction with a friend. Overall, character disposition and behavior valence significantly influenced children's judgments. Moral, liking, and consequence-of-behavior judgments varied significantly by character disposition for both positive behavior scenarios. In contrast, there were fewer significant findings as a function of character disposition for negative behavior scenarios, suggesting that the negative behavior cue somewhat diminished the effect of character disposition on children's judgments. The authors discuss preschool students' coordination of information about valence of behavior and character disposition and the students' reluctance to judge that misbehavior warrants punitive consequence.

Pandemic Influenza A(H1N1)v in New Zealand: the Experience from April to August 2009

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 2009  |  Pubmed ID: 19712648

Following the detection of imported cases of pandemic influenza A(H1N1)v on 25 April 2009, New Zealand implemented containment measures that appeared to slow establishment of the pandemic during May. The pandemic accelerated markedly in June, reaching a peak within four to six weeks, and has been declining since mid-July. By 23 August there had been 3,179 recorded cases (97.8% reported as confirmed), including 972 hospitalisations, 114 intensive care admissions, and 16 deaths. Influenza-like illness (ILI) surveillance in general practice suggests that 7.5% (95% CI: 3.4-11.2) of the population of New Zealand had symptomatic infection, giving a case fatality ratio of 0.005%. Hospitalisations were markedly higher for Māori (age standardised relative risk (RR)=3.0, 95% CI: 2.9-3.2) and Pacific peoples (RR=6.7, 95% CI: 6.2-7.1) compared with Europeans and others. The apparent decline of the pandemic (shown by all surveillance systems) cannot be fully explained. New Zealand remains in the middle of its traditional influenza season, the influenza A(H1N1)v virus appears relatively infectious, and we estimate that only about 11% of the population have been infected by this novel agent.

Do Ethnic and Socio-economic Inequalities in Mortality Vary by Region in New Zealand? An Application of Hierarchical Bayesian Modelling

Social Science & Medicine (1982). Oct, 2009  |  Pubmed ID: 19713021

We hypothesised that ethnic and socio-economic inequality in mortality might vary by region in New Zealand. Linked 2001-2004 census-mortality data were stratified by region (District Health Boards or DHBs), sex, age and ethnic groups, and income quintiles. To accommodate data sparseness, and to achieve accurate estimates of DHB-specific mortality rates and rate ratios by ethnicity and income, we used hierarchical Bayesian methods. To aid presentation of results, we used posterior mortality rates from the models to calculate directly standardised rates and rate ratios, with credible intervals. Māori-European/Other mortality rate ratios were often similar across DHBs, but Waitemata and Canterbury DHBs (both predominantly urban areas with low Māori population) had significantly lower rate ratios. In contrast, Bay of Plenty and Waikato DHBs (heterogeneous by both ethnicity and socio-economic position) had significantly higher rate ratios. There was little variation in mortality inequalities by income across DHBs. Examining the underlying rates for ethnic and income groups separately, there were significant variations across DHBs, but these were often correlated such that the ethnic or income rate ratio was similar across DHBs. The application of hierarchical Bayesian allowed more definitive conclusions than routine empirical methods when comparing small populations such as social groups across regions. The range of hierarchical Bayesian estimates of Māori mortality and Māori:European rate ratios across regions was considerably narrower than empirical standardisation estimates.

Passive Range of Motion Functional Magnetic Resonance Imaging Localizing Sensorimotor Cortex in Sedated Children

Journal of Neurosurgery. Pediatrics. Oct, 2009  |  Pubmed ID: 19795962

In this study, the authors examined whether passive range of motion (ROM) under conscious sedation could be used to localize sensorimotor cortex using functional MR (fMR) imaging in children as part of their presurgical evaluation.

Safety of Prolonged, Repeated Administration of a Pulmonary Formulation of Tissue Plasminogen Activator in Mice

Pulmonary Pharmacology & Therapeutics. Apr, 2010  |  Pubmed ID: 19879371

Disruption of fibrinolytic homeostasis participates in the pathogenesis of severe lung diseases like acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF) and plastic bronchitis. We have developed a pulmonary formulation of tissue plasminogen activator (pf-tPA) that withstands nebulization and reaches the lower airways.

Vocal Competition in Male Xenopus Laevis Frogs

Behavioral Ecology and Sociobiology. Nov, 2010  |  Pubmed ID: 21442049

Male Xenopus laevis frogs produce underwater advertisement calls that attract gravid females and suppress calling by male competitors. Here we explore whether groups of males establish vocal ranks and whether auditory cues alone suffice for vocal suppression. Tests of male-male pairs within assigned groups reveal linear vocal dominance relations, in which each male has a defined rank. Both the duration over which males interact, as well as the number of competitive opportunities, affect linearity. Linear dominance across the group is stable for about 2 weeks; rank is dynamic. Males engage in physical interactions (clasping) while paired but clasping and vocal rank are not correlated. Playbacks of advertisement calls suppress calling and calls from high- and low-ranking males are equally effective. Thus, auditory cues alone suffice to suppress vocal behavior. Playback intensities equivalent to a nearby male advertising effectively suppress calling while low-intensity playbacks are either ineffective or stimulate vocal behavior. X. laevis advertisement calls are biphasic, composed of alternating fast and slow click trills. Approximately half the males tested are more vocally suppressed by all slow than by all fast trills; thus, these males can distinguish between the two phases. The fully aquatic family Pipidae diverged from terrestrial ancestors approximately 170 mya. Vocal suppression in the X. laevis mating system may represent the translation of an ancient anuran social strategy to underwater life.

White-matter Abnormalities in Brain During Early Abstinence from Methamphetamine Abuse

Psychopharmacology. Mar, 2010  |  Pubmed ID: 20101394

Previous studies revealed microstructural abnormalities in prefrontal white matter and corpus callosum of long-term abstinent chronic methamphetamine abusers. In view of the importance of the early abstinence period in treatment retention, we compared 23 methamphetamine-dependent subjects abstinent from methamphetamine for 7-13 days with 18 healthy comparison subjects. As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence.

Risk Perception and Moralization Among Smokers in the USA and Denmark: a Qualitative Approach

British Journal of Health Psychology. Nov, 2010  |  Pubmed ID: 20181322

The present research explored the role that culture plays in smokers' description of their risk perceptions and experiences as targets of moralization.

Application of a System Dynamics Model to Inform Investment in Smoking Cessation Services in New Zealand

American Journal of Public Health. Jul, 2010  |  Pubmed ID: 20466963

We estimated the long-term effects of smoking cessation interventions to inform government decision-making regarding investment in tobacco control.

The Health of Children in Sole-parent Families in New Zealand: Results of a Population-based Cross-sectional Survey

Australian and New Zealand Journal of Public Health. Jun, 2010  |  Pubmed ID: 20618269

To investigate whether children in sole-parent families in New Zealand bear excess risks of poor mental and physical health relative to children in two parent families. DATA SOURCES AND STATISTICAL METHODS: The data source was the 2006/07 New Zealand Health Survey, a nationally representative household survey that sampled 502 children (5-14 years) of sole mothers and 1,281 children of partnered mothers.

Acclimation of Photosynthetic Characteristics of the Moss Pleurozium Schreberi to Among-habitat and Within-canopy Light Gradients

Plant Biology (Stuttgart, Germany). Sep, 2010  |  Pubmed ID: 20701697

Light availability varies strongly among moss habitats and within the moss canopy, and vertical variation in light within the canopy further interacts with the age gradient. The interacting controls by habitat and canopy light gradient and senescence have not been studied extensively. We measured light profiles, chlorophyll (Chl), carotenoid (Car) and nitrogen (N) concentrations, and photosynthetic electron transport capacity (J(max)) along habitat and canopy light gradients in the widespread, temperate moss Pleurozium schreberi to separate sources of variation in moss chemical and physiological traits. We hypothesised that this species, like typical feather mosses with both apical and lateral growth, exhibits greater plasticity in the canopy than between habitats due to deeper within-canopy light gradients. For the among-habitat light gradient, Chl, Chl/N and Chl/Car ratio increased with decreasing light availability, indicating enhanced light harvesting in lower light and higher capacity for photoprotection in higher light. N and J(max) were independent of habitat light availability. Within the upper canopy, until 50-60% above-canopy light, changes in moss chemistry and photosynthetic characteristics were analogous to patterns observed for the between-habitat light gradient. In contrast, deeper canopy layers reflected senescence of moss shoots, with pigment and nitrogen concentrations and photosynthetic capacity decreasing with light availability. Thus, variation in chemical and physiological traits within the moss canopy is a balance between acclimation and senescence. This study demonstrates extensive light-dependent variation in moss photosynthetic traits, but also that between-habitat and within-canopy light gradient affects moss physiology and chemistry differently.

Racism and Health in New Zealand

Ethnicity & Health. Aug, 2010  |  Pubmed ID: 21171223

All-trans Retinoic Acid Modulates Cancer Stem Cells of Glioblastoma Multiforme in an MAPK-dependent Manner

Anticancer Research. Dec, 2010  |  Pubmed ID: 21187470

Glioblastoma multiforme (GBM), a grade IV glioma, appears to harbor therapy-resistant cancer stem cells (CSCs) that are the major cause of recurrence. All-trans retinoic acid (ATRA), a derivative of retinoid, is capable of differentiating a variety of stem cells, as well as normal neural progenitor cells, and down-regulates expression of the stem cell marker nestin. This study investigated the effects of ATRA on differentiation, proliferation, self-renewal, and signaling pathways of CSCs in GBM. CSCs differentiated into glial and neuronal lineages at low concentrations of ATRA (10 μM). Proliferation and self renewal of neurospheres were reduced following ATRA, although ATRA induced apopotsis at higher (40 μM) concentrations. Analysis of mitogen-activated protein kinase signaling pathways, specifically extracellular signal-regulated kinases (ERK1/2), showed that ATRA-induced alterations in ERK1/2 were associated with regulation of differentiation, proliferation and apoptosis. These results emphasize that low doses of ATRA may have therapeutic potential by differentiating GBM CSCs and rendering them sensitive to targeted therapy.

Web Servers and Services for Electrostatics Calculations with APBS and PDB2PQR

Journal of Computational Chemistry. May, 2011  |  Pubmed ID: 21425296

APBS and PDB2PQR are widely utilized free software packages for biomolecular electrostatics calculations. Using the Opal toolkit, we have developed a Web services framework for these software packages that enables the use of APBS and PDB2PQR by users who do not have local access to the necessary amount of computational capabilities. This not only increases accessibility of the software to a wider range of scientists, educators, and students but also increases the availability of electrostatics calculations on portable computing platforms. Users can access this new functionality in two ways. First, an Opal-enabled version of APBS is provided in current distributions, available freely on the web. Second, we have extended the PDB2PQR web server to provide an interface for the setup, execution, and visualization of electrostatic potentials as calculated by APBS. This web interface also uses the Opal framework which ensures the scalability needed to support the large APBS user community. Both of these resources are available from the APBS/PDB2PQR website: http://www.poissonboltzmann.org/.

Description of a New Octoploid Frog Species (Anura: Pipidae: Xenopus) from the Democratic Republic of the Congo, with a Discussion of the Biogeography of African Clawed Frogs in the Albertine Rift

Journal of Zoology (London, England : 1987). Apr, 2011  |  Pubmed ID: 21546992

We describe a new octoploid species of African clawed frog (Xenopus) from the Lendu Plateau in the northern Albertine Rift of eastern Democratic Republic of the Congo. This species is the sister taxon of Xenopus vestitus (another octoploid), but is distinguished by a unique morphology, vocalization and molecular divergence in mitochondrial and autosomal DNA. Using a comprehensive genetic sample, we provide new information on the species ranges and intra-specific diversity of African clawed frogs from the Albertine Rift, including the details of a small range extension for the critically endangered Xenopus itombwensis and previously uncharacterized variation in Xenopus laevis. We also detail a new method for generating cytogenetic preparations in the field that can be stored at room temperature for up to 3 weeks. While extending our understanding of the extant diversity in the Albertine Rift, this new species highlights components of species diversity in ancestral African clawed frogs that are not represented by known extant descendants.

Global Control of Diabetes: Information for Action

Lancet. Jul, 2011  |  Pubmed ID: 21705073

Mortality Among the Working Age Population Receiving Incapacity Benefits in New Zealand, 1981-2004

Social Science & Medicine (1982). Aug, 2011  |  Pubmed ID: 21778007

Like many OECD countries New Zealand has experienced a large increase in the number of working-age people receiving incapacity benefits in the last 3 decades, despite apparent improvements in population health. This paper examines trends in mortality rates of people receiving sickness benefit or invalid's benefit (SBIB) between 1981 and 2004 using repeated cohort studies (linking the 1981, 1986, 1991, 1996, and 2001 censuses to mortality data). Mortality rates, standardised for age and ethnicity, were calculated for each census cohort for 25-64 year olds by benefit receipt status. Standardised rate differences and rate ratios and 95% confidence intervals were calculated to measure disparities on both absolute and relative scales. Between 1981 and 2004 overall SBIB receipt increased from 2% to 5% of the working age population. Mortality rates were at least three times higher in the SBIB than the non-SBIB group at all points in time for men and women. Mortality rates declined in all groups, for example in men receiving SBIB, mortality decreased from 2354/100,000 in the 1981-84 cohort to 1371/100,000 in the 2001-04 cohort. Absolute inequalities between SBIB and non-SBIB declined in both men and women (for example in women standardised rate differences decreased from 954/100,000 to 688/100,000) but relative inequalities remained largely stable (for example in men the risk ratio increased from 4.27 to 4.54). Mortality rates declined more in sickness benefit than invalid's benefit recipients. The substantial expansion of SBIB receipt in New Zealand has not been accompanied by any reduction in the excess mortality risk experienced by SBIB recipients. These findings are likely to reflect the changing nature of the economy, labour force and disability experience in New Zealand.

The Pervasive Effects of Racism: Experiences of Racial Discrimination in New Zealand over Time and Associations with Multiple Health Domains

Social Science & Medicine (1982). Feb, 2012  |  Pubmed ID: 22204840

Self-reported experience of racial discrimination has been linked to a range of health outcomes in various countries and for different ethnic groups. This study builds on previous work in New Zealand to further investigate the prevalence of self-reported experience of racial discrimination by ethnicity, changes over time and associations with multiple health measures. The study uses data from the 2002/03 (n=12,500) and 2006/07 (n=12,488) New Zealand Health Surveys, nationally representative population-based surveys of adults (15+ years). Reported experience of racial discrimination was measured in both surveys and covered 5 items: experience of an ethnically motivated physical or verbal attack; and unfair treatment because of ethnicity by a health professional, in work, or when gaining housing. Ethnicity was classified as Maori, Pacific, Asian or European. Health indicators included measures of: mental health (SF36 mental health scale, psychological distress, doctor diagnosed mental health condition); physical health (self-rated health, SF36 physical functioning scale, cardiovascular disease); and health risk (smoking, hazardous drinking, excess body fat). Logistic regression was used to examine changes in prevalence of reported experience of racial discrimination over time and associations with health. Reported experience of racial discrimination increased between 2002/03 (28.1% ever) and 2006/07 (35.0% ever) among Asian peoples but remained largely unchanged for other ethnic groupings (Maori 29.5%, Pacific 23.0%, European 13.5%). Experience of racial discrimination was associated with all negative health measures except excess body fat. Where there were significant associations, a dose-response relationship was also evident. We conclude that racial discrimination experienced across a range of settings has the potential to impact on a wide range of health outcomes and risk factors. While ongoing research is needed to understand the multifarious nature of racism and the pathways by which it leads to poor health, it is feasible to monitor experiences of racial discrimination in national surveys.

Cigarette Smoking and White Matter Microstructure

Psychopharmacology. Jan, 2012  |  Pubmed ID: 22215225

RATIONALE: Diffusion tensor imaging has been used before in testing associations between cigarette smoking and white matter integrity, with inconsistent results. Published reports indicate higher fractional anisotropy (FA, a measure of linear water diffusion) in some brain regions and lower FA in others in adult smokers compared to nonsmokers. Adolescent smokers exhibited elevated FA at several brain regions and a positive correlation of FA in the genu corpus callosum with exposure to smoking (pack-years). OBJECTIVE: To help resolve prior discrepancies, we studied adults, sampling multiple brain regions, and testing for relationships to clinical features of nicotine dependence and exposure to smoking. METHODS: Brain MRI scans (1.5 T) were acquired, and FA and apparent diffusion coefficient (ADC, a measure of random diffusion) were assayed in corpus callosum and prefrontal white matter, corona radiata, internal capsule, cingulum bundle, and hippocampal perforant fibers in 18 smokers (33.7 ± 7.9 years of age) and 18 age- and gender-matched nonsmokers. RESULTS: ADC showed no group difference, but smokers had higher (4.3-21.1%) FA than nonsmokers. The differences were significant in right prefrontal white matter, cingulum, and genu corpus callosum. FA in several regions was negatively correlated with nicotine dependence or cigarettes/day. CONCLUSIONS: Combined with earlier findings, these results suggest a model of changing trajectories whereby FA is higher with tobacco exposure during adolescence and declines with continued smoking in adulthood. This notion is supported by the observation that, at multiple sampling sites, participants who had started smoking earlier in life had higher FA than those who had started later.