Toshiki Ochi Princess Margaret Cancer Centre University Health Network Biography Publications Institution JoVE Articles Toshiki Ochi has not added a biography. If you are Toshiki Ochi and would like to personalize this page please email our Author Liaison for assistance. Publications BET Bromodomain Inhibition Enhances T Cell Persistence and Function in Adoptive Immunotherapy Models The Journal of Clinical Investigation. Sep, 2016 | Pubmed ID: 27548527 Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PloS One. 2016 | Pubmed ID: 27213277 CD4(+) and CD8(+) TCRβ Repertoires Possess Different Potentials to Generate Extraordinarily High-avidity T Cells Scientific Reports. Mar, 2016 | Pubmed ID: 27030642 CDR3β Sequence Motifs Regulate Autoreactivity of Human Invariant NKT Cell Receptors Journal of Autoimmunity. Apr, 2016 | Pubmed ID: 26748722 Induction of WT1-specific Human CD8+ T Cells from Human HSCs in HLA Class I Tg NOD/SCID/IL2rgKO Mice Blood. Feb, 2016 | Pubmed ID: 26702062 Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25943533 Specific Roles of Each TCR Hemichain in Generating Functional Chain-centric TCR Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25710913 Adoptive Transfer of Genetically Engineered WT1-specific Cytotoxic T Lymphocytes Does Not Induce Renal Injury Journal of Hematology & Oncology. Jan, 2014 | Pubmed ID: 24393438 Development of a Novel Redirected T-cell-based Adoptive Immunotherapy Targeting Human Telomerase Reverse Transcriptase for Adult T-cell Leukemia Blood. Jun, 2013 | Pubmed ID: 23641014 Co-introduced Functional CCR2 Potentiates in Vivo Anti-lung Cancer Functionality Mediated by T Cells Double Gene-modified to Express WT1-specific T-cell Receptor PloS One. 2013 | Pubmed ID: 23441216 Aurora Kinase A-specific T-cell Receptor Gene Transfer Redirects T Lymphocytes to Display Effective Antileukemia Reactivity Blood. Jan, 2012 | Pubmed ID: 22025529 Novel Adoptive T-cell Immunotherapy Using a WT1-specific TCR Vector Encoding Silencers for Endogenous TCRs Shows Marked Antileukemia Reactivity and Safety Blood. Aug, 2011 | Pubmed ID: 21673345 Gemcitabine Enhances Wilms' Tumor Gene WT1 Expression and Sensitizes Human Pancreatic Cancer Cells with WT1-specific T-cell-mediated Antitumor Immune Response Cancer Immunology, Immunotherapy : CII. Sep, 2011 | Pubmed ID: 21607557 Requisite Considerations for Successful Adoptive Immunotherapy with Engineered T-lymphocytes Using Tumor Antigen-specific T-cell Receptor Gene Transfer Expert Opinion on Biological Therapy. Jun, 2011 | Pubmed ID: 21413911 Adoptive T-cell Immunotherapy Using T-cell Receptor Gene Transfer: Aiming at a Cure for Cancer Immunotherapy. Feb, 2011 | Pubmed ID: 21322752 Activation of T-cell Receptor Signaling in Peripheral T-cell Lymphoma Cells Plays an Important Role in the Development of Lymphoma-associated Hemophagocytosis International Journal of Hematology. Feb, 2011 | Pubmed ID: 21229399 Subtypes of Familial Hemophagocytic Lymphohistiocytosis in Japan Based on Genetic and Functional Analyses of Cytotoxic T Lymphocytes PloS One. Nov, 2010 | Pubmed ID: 21152410 Generation of Functional Human T-cell Subsets with HLA-restricted Immune Responses in HLA Class I Expressing NOD/SCID/IL2r Gamma(null) Humanized Mice Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20615947 Human Herpesvirus 6 Infection Impairs Toll-like Receptor Signaling Virology Journal. May, 2010 | Pubmed ID: 20459723 Application of Adoptive T-cell Therapy Using Tumor Antigen-specific T-cell Receptor Gene Transfer for the Treatment of Human Leukemia Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20454585 Germ Cell Tumor Concomitant with Acquired Immune Deficiency Syndrome Internal Medicine (Tokyo, Japan). 2009 | Pubmed ID: 20009406 Aurora-A Kinase: a Novel Target Both for Cellular Immunotherapy and Molecular Target Therapy Against Human Leukemia Expert Opinion on Therapeutic Targets. Dec, 2009 | Pubmed ID: 19821797 HBZ is an Immunogenic Protein, but Not a Target Antigen for Human T-cell Leukemia Virus Type 1-specific Cytotoxic T Lymphocytes The Journal of General Virology. Aug, 2009 | Pubmed ID: 19423550 Identification of a Novel Epitope Derived from CML66 That is Recognized by Anti-leukaemia Cytotoxic T Lymphocytes British Journal of Haematology. Jun, 2009 | Pubmed ID: 19388930 Clinical Efficacy of WT1 Peptide Vaccination in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome American Journal of Hematology. May, 2009 | Pubmed ID: 19338044 Aurora-A Kinase: a Novel Target of Cellular Immunotherapy for Leukemia Blood. Jan, 2009 | Pubmed ID: 18820130 Identification of an Epitope Derived from CML66, a Novel Tumor-associated Antigen Expressed Broadly in Human Leukemia, Recognized by Human Leukocyte Antigen-A*2402-restricted Cytotoxic T Lymphocytes Cancer Science. Jul, 2008 | Pubmed ID: 18422754 Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunology and Infection
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunology and Infection
