Urs Christen Pharmazentrum Frankfurt / ZAFES Goethe University Hospital Frankfurt Biography Publications Institution JoVE Articles Urs Christen has not added a biography. If you are Urs Christen and would like to personalize this page please email our Author Liaison for assistance. Publications Epitope Spreading of the Anti-CYP2D6 Antibody Response in Patients with Autoimmune Hepatitis and in the CYP2D6 Mouse Model Journal of Autoimmunity. Nov, 2011 | Pubmed ID: 21795021 Do Viral Infections Protect from or Enhance Type 1 Diabetes and How Can We Tell the Difference? Cellular & Molecular Immunology. May, 2011 | Pubmed ID: 21258361 Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to Live Borrelia Burgdorferi: the Role of Monocytes and Interleukin-1 PLoS Pathogens. 2010 | Pubmed ID: 20976193 CXCL10 Promotes Liver Fibrosis by Prevention of NK Cell Mediated Hepatic Stellate Cell Inactivation Journal of Autoimmunity. Dec, 2010 | Pubmed ID: 20932719 Cytochrome P450 2D6 As a Model Antigen Digestive Diseases (Basel, Switzerland). 2010 | Pubmed ID: 20460894 Enterovirus Infection of Human Beta-cells Activates Dendritic Cells and Triggers Innate Antiviral Responses: Are Enteroviruses Convicted Now? Diabetes. May, 2010 | Pubmed ID: 20427698 Viral Triggers for Autoimmunity: is the 'glass of Molecular Mimicry' Half Full or Half Empty? Journal of Autoimmunity. Feb, 2010 | Pubmed ID: 19716269 Adenovirus E3 MHC Inhibitory Genes but Not TNF/Fas Apoptotic Inhibitory Genes Expressed in Beta Cells Prevent Autoimmune Diabetes Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19887639 New Animal Models for Autoimmune Hepatitis Seminars in Liver Disease. Aug, 2009 | Pubmed ID: 19675999 Breaking Tolerance to the Natural Human Liver Autoantigen Cytochrome P450 2D6 by Virus Infection The Journal of Experimental Medicine. Jun, 2008 | Pubmed ID: 18474629 Viral Infection--a Cure for Type 1 Diabetes? Current Medicinal Chemistry. 2007 | Pubmed ID: 17691946 Systemic Anti-TNFalpha Treatment Restores Diabetes-impaired Skin Repair in Ob/ob Mice by Inactivation of Macrophages The Journal of Investigative Dermatology. Sep, 2007 | Pubmed ID: 17460730 Animal Models for Autoimmune Hepatitis Autoimmunity Reviews. Apr, 2007 | Pubmed ID: 17412303 Minimal Impact of a De Novo-expressed Beta-cell Autoantigen on Spontaneous Diabetes Development in NOD Mice Diabetes. Apr, 2007 | Pubmed ID: 17395746 Chemokines As Drug Targets in Type 1 Diabetes Endocrine, Metabolic & Immune Disorders Drug Targets. Mar, 2007 | Pubmed ID: 17346199 Cure of Chronic Viral Infection and Virus-induced Type 1 Diabetes by Neutralizing Antibodies Clinical & Developmental Immunology. Jun-Dec, 2006 | Pubmed ID: 17162375 SOCS-1 Protects from Virally-induced CD8 T Cell Mediated Type 1 Diabetes Journal of Autoimmunity. Nov, 2006 | Pubmed ID: 17045460 Cure of Chronic Viral Infection and Virus-induced Type 1 Diabetes by Neutralizing Antibodies Clinical & Developmental Immunology. Mar, 2006 | Pubmed ID: 16603445 Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease Clinical Microbiology Reviews. Jan, 2006 | Pubmed ID: 16418524 Islet-specific Expression of CXCL10 Causes Spontaneous Islet Infiltration and Accelerates Diabetes Development Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148094 Infections and Autoimmunity--good or Bad? Journal of Immunology (Baltimore, Md. : 1950). Jun, 2005 | Pubmed ID: 15944245 Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with IFN-gamma-inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15728483 IP-10 and Type 1 Diabetes: a Question of Time and Location Autoimmunity. Aug, 2004 | Pubmed ID: 15672495 Manipulating the Type 1 Vs Type 2 Balance in Type 1 Diabetes Immunologic Research. 2004 | Pubmed ID: 15531772 A Viral Epitope That Mimics a Self Antigen Can Accelerate but Not Initiate Autoimmune Diabetes The Journal of Clinical Investigation. Nov, 2004 | Pubmed ID: 15520861 IP-10 and Type 1 Diabetes: a Question of Time and Location Autoimmunity. Jun, 2004 | Pubmed ID: 15518041 Initiation of Autoimmunity Current Opinion in Immunology. Dec, 2004 | Pubmed ID: 15511670 CD8alphaalpha-mediated Survival and Differentiation of CD8 Memory T Cell Precursors Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15105501 Virally Induced Inflammation and Therapeutic Avenues in Type 1 Diabetes Endocrinology and Metabolism Clinics of North America. Mar, 2004 | Pubmed ID: 15053894 Induction, Acceleration or Prevention of Autoimmunity by Molecular Mimicry Molecular Immunology. Feb, 2004 | Pubmed ID: 15036917 Virally Induced Inflammation Triggers Fratricide of Fas-ligand-expressing Beta-cells Diabetes. Mar, 2004 | Pubmed ID: 14988242 Cure of Prediabetic Mice by Viral Infections Involves Lymphocyte Recruitment Along an IP-10 Gradient The Journal of Clinical Investigation. Jan, 2004 | Pubmed ID: 14702111 Among CXCR3 Chemokines, IFN-gamma-inducible Protein of 10 KDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-gamma (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14662890 Cytokines and Chemokines in Virus-induced Autoimmunity Advances in Experimental Medicine and Biology. 2003 | Pubmed ID: 12613580 CD4+ T Cells Are Required for Secondary Expansion and Memory in CD8+ T Lymphocytes Nature. Feb, 2003 | Pubmed ID: 12594515 Transgenic Animal Models for Type 1 Diabetes: Linking a Tetracycline-inducible Promoter with a Virus-inducible Mouse Model Transgenic Research. Dec, 2002 | Pubmed ID: 12509133 Molecular Anatomy of Antigen-specific CD8(+) T Cell Engagement and Synapse Formation in Vivo Nature Immunology. Oct, 2002 | Pubmed ID: 12352968 Discrete Proteolysis of Focal Contact and Adherens Junction Components in Porphyromonas Gingivalis-infected Oral Keratinocytes: a Strategy for Cell Adhesion and Migration Disabling Infection and Immunity. Oct, 2002 | Pubmed ID: 12228316 Apoptosis of Autoreactive CD8 Lymphocytes As a Potential Mechanism for the Abrogation of Type 1 Diabetes by Islet-specific TNF-alpha Expression at a Time when the Autoimmune Process is Already Ongoing Annals of the New York Academy of Sciences. Apr, 2002 | Pubmed ID: 12021099 The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice Edith Hintermann1, Janine Ehser1, Urs Christen1 1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt JoVE 3644 Medicine
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice Edith Hintermann1, Janine Ehser1, Urs Christen1 1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt JoVE 3644 Medicine