Vince Castranova National Institute for Occupational Safety and Health Biography Publications Institution JoVE Articles Vince Castranova has not added a biography. If you are Vince Castranova and would like to personalize this page please email our Author Liaison for assistance. Publications Nanoparticle Inhalation Alters Systemic Arteriolar Vasoreactivity Through Sympathetic and Cyclooxygenase-mediated Pathways Nanotoxicology. Nov, 2012 | Pubmed ID: 21830860 MiR-190-mediated Downregulation of PHLPP Contributes to Arsenic-induced Akt Activation and Carcinogenesis Toxicological Sciences : an Official Journal of the Society of Toxicology. Oct, 2011 | Pubmed ID: 21750348 Microprocessor of MicroRNAs: Regulation and Potential for Therapeutic Intervention Molecular Cancer. 2010 | Pubmed ID: 20515486 Single- and Multi-wall Carbon Nanotubes Versus Asbestos: Are the Carbon Nanotubes a New Health Risk to Humans? Journal of Toxicology and Environmental Health. Part A. 2010 | Pubmed ID: 20155580 DNA Double-strand Breaks by Asbestos, Silica, and Titanium Dioxide: Possible Biomarker of Carcinogenic Potential? American Journal of Respiratory Cell and Molecular Biology. Aug, 2010 | Pubmed ID: 19783790 The Role of P53 in Silica-induced Cellular and Molecular Responses Associated with Carcinogenesis Journal of Toxicology and Environmental Health. Part A. 2009 | Pubmed ID: 20077225 Toxicology of Nanomaterials: Permanent Interactive Learning Particle and Fibre Toxicology. 2009 | Pubmed ID: 19863807 Overlapping Signature Genes Between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma European Journal of Gastroenterology & Hepatology. Nov, 2009 | Pubmed ID: 19826380 Signature Genes for Both Hepatoblastoma and Hepatocellular Carcinoma European Journal of Gastroenterology & Hepatology. Oct, 2009 | Pubmed ID: 19749507 JNK1 Activation Predicts the Prognostic Outcome of the Human Hepatocellular Carcinoma Molecular Cancer. 2009 | Pubmed ID: 19686584 JNK1, a Potential Therapeutic Target for Hepatocellular Carcinoma Biochimica Et Biophysica Acta. Dec, 2009 | Pubmed ID: 19591900 Understanding Biophysicochemical Interactions at the Nano-bio Interface Nature Materials. Jul, 2009 | Pubmed ID: 19525947 Lung Cancer-associated JmjC Domain Protein Mdig Suppresses Formation of Tri-methyl Lysine 9 of Histone H3 Cell Cycle (Georgetown, Tex.). Jul, 2009 | Pubmed ID: 19502796 Beyond Apoptosis of JNK1 in Liver Cancer Cell Cycle (Georgetown, Tex.). Apr, 2009 | Pubmed ID: 19270500 Reactive Oxygen Species- and Nitric Oxide-mediated Lung Inflammation and Mitochondrial Dysfunction in Wild-type and INOS-deficient Mice Exposed to Diesel Exhaust Particles Journal of Toxicology and Environmental Health. Part A. 2009 | Pubmed ID: 19267316 Sustained JNK1 Activation is Associated with Altered Histone H3 Methylations in Human Liver Cancer Journal of Hepatology. Feb, 2009 | Pubmed ID: 19041150 Characterization of an Alternatively Spliced GADD45alpha, GADD45alpha1 Isoform, in Arsenic-treated Epithelial Cells Molecular Carcinogenesis. May, 2009 | Pubmed ID: 18942077 Tumor Promoting or Tumor Suppressing of NF-kappa B, a Matter of Cell Context Dependency International Reviews of Immunology. 2008 | Pubmed ID: 18574736 Three-dimensional Localization and Quantification of PAF-induced Gap Formation in Intact Venular Microvessels American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2008 | Pubmed ID: 18515648 Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity American Journal of Respiratory Cell and Molecular Biology. May, 2008 | Pubmed ID: 18096873 Nuclear Factor-kappaB, an Unappreciated Tumor Suppressor Cancer Research. Dec, 2007 | Pubmed ID: 18056430 Incorporation of an Internal Ribosome Entry Site-dependent Mechanism in Arsenic-induced GADD45 Alpha Expression Cancer Research. Jul, 2007 | Pubmed ID: 17616671 Proteomic Analysis of Bronchoalveolar Lavage Fluid: Effect of Acute Exposure to Diesel Exhaust Particles in Rats Environmental Health Perspectives. May, 2007 | Pubmed ID: 17520064 Particle Size-dependent Radical Generation from Wildland Fire Smoke Toxicology. Jul, 2007 | Pubmed ID: 17482744 Comparative Cytotoxicity of Cadmium and Mercury in a Human Bronchial Epithelial Cell Line (BEAS-2B) and Its Role in Oxidative Stress and Induction of Heat Shock Protein 70 Journal of Toxicology and Environmental Health. Part A. May, 2007 | Pubmed ID: 17454561 Comparative in Vitro Toxicity of Grape- and Citrus-farm Dusts Journal of Toxicology and Environmental Health. Part A. Jan, 2007 | Pubmed ID: 17365569 Loss of Ikkbeta Promotes Migration and Proliferation of Mouse Embryo Fibroblast Cells The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 16966325 Predicting Cancer Drug Response by Proteomic Profiling Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2006 | Pubmed ID: 16899605 Constructing Molecular Classifiers for the Accurate Prognosis of Lung Adenocarcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2006 | Pubmed ID: 16740756 Nucleolin Links to Arsenic-induced Stabilization of GADD45alpha MRNA Nucleic Acids Research. 2006 | Pubmed ID: 16421274 Involvement of Protein Kinase C in Crystalline Silica-induced Activation of the MAP Kinase and AP-1 Pathway American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2006 | Pubmed ID: 16169898 Deficiency in Ikkbeta Gene Enhances Arsenic-induced Gadd45alpha Expression Molecular and Cellular Biochemistry. Nov, 2005 | Pubmed ID: 16283526 Heat Shock Protein 70 As an Indicator of Early Lung Injury Caused by Exposure to Arsenic Molecular and Cellular Biochemistry. Sep, 2005 | Pubmed ID: 16132727 Testing of Fibrous Particles: Short-term Assays and Strategies Inhalation Toxicology. Sep, 2005 | Pubmed ID: 16040559 The Human Mineral Dust-induced Gene, Mdig, is a Cell Growth Regulating Gene Associated with Lung Cancer Oncogene. Jul, 2005 | Pubmed ID: 15897898 Inhibition of NF-kappaB Stabilizes Gadd45alpha MRNA Biochemical and Biophysical Research Communications. Apr, 2005 | Pubmed ID: 15721278 Essential Role of P53 in Silica-induced Apoptosis American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2005 | Pubmed ID: 15557088 Loss of Caveolin-1 Polarity Impedes Endothelial Cell Polarization and Directional Movement The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15504729 FMLP-stimulated Neutrophils Increase Endothelial [Ca2+]i and Microvessel Permeability in the Absence of Adhesion: Role of Reactive Oxygen Species American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2005 | Pubmed ID: 15498822 Cdc42 Regulates Arsenic-induced NADPH Oxidase Activation and Cell Migration Through Actin Filament Reorganization The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15492012 The Sources of Inflammatory Mediators in the Lung After Silica Exposure Environmental Health Perspectives. Dec, 2004 | Pubmed ID: 15579413 Blackberry Extracts Inhibit Activating Protein 1 Activation and Cell Transformation by Perturbing the Mitogenic Signaling Pathway Nutrition and Cancer. 2004 | Pubmed ID: 15572301 PbCrO4 Mediates Cellular Responses Via Reactive Oxygen Species Molecular and Cellular Biochemistry. Jan, 2004 | Pubmed ID: 14971658 Inhibition of AP-1 and Neoplastic Transformation by Fresh Apple Peel Extract The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14665633 Internalization of Caveolin-1 Scaffolding Domain Facilitated by Antennapedia Homeodomain Attenuates PAF-induced Increase in Microvessel Permeability American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2004 | Pubmed ID: 12946927 Inhibitor of Nuclear Factor KappaB Kinase Deficiency Enhances Oxidative Stress and Prolongs C-Jun NH2-terminal Kinase Activation Induced by Arsenic Cancer Research. Nov, 2003 | Pubmed ID: 14633691 New Perspectives in Arsenic-induced Cell Signal Transduction Journal of Inorganic Biochemistry. Aug, 2003 | Pubmed ID: 12888263 Inhalation Exposure of Rats to Asphalt Fumes Generated at Paving Temperatures Alters Pulmonary Xenobiotic Metabolism Pathways Without Lung Injury Environmental Health Perspectives. Jul, 2003 | Pubmed ID: 12842776 Effect of Chlorogenic Acid on Hydroxyl Radical Molecular and Cellular Biochemistry. May, 2003 | Pubmed ID: 12841649 Role of Reactive Oxygen Species and MAPKs in Vanadate-induced G(2)/M Phase Arrest Free Radical Biology & Medicine. May, 2003 | Pubmed ID: 12726921 P38 Signaling-mediated Hypoxia-inducible Factor 1alpha and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12213806 In Vivo Bioassays of Acute Asbestosis and Its Correlation with ESR Spectroscopy and Imaging in Redox Status Molecular and Cellular Biochemistry. May-Jun, 2002 | Pubmed ID: 12162455 Generation of Reactive Oxygen Species in the Enzymatic Reduction of PbCrO4 and Related DNA Damage Molecular and Cellular Biochemistry. May-Jun, 2002 | Pubmed ID: 12162449 Arsenite-induced Cdc25C Degradation is Through the KEN-box and Ubiquitin-proteasome Pathway Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11842186 Protective Roles of NF-kappa B for Chromium(VI)-induced Cytotoxicity is Revealed by Expression of Ikappa B Kinase-beta Mutant The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11726646 Whole-Body Nanoparticle Aerosol Inhalation Exposures Jinghai Yi1,2, Bean T. Chen3, Diane Schwegler-Berry3, Dave Frazer3, Vince Castranova3, Carroll McBride1, Travis L. Knuckles1,2, Phoebe A. Stapleton1,2, Valerie C. Minarchick1,2, Timothy R. Nurkiewicz1,2 1Department of Physiology and Pharmacology, School of Medicine, West Virginia University, 2Center for Cardiovascular and Respiratory Sciences, West Virginia University, 3National Institute for Occupational Safety and Health JoVE 50263 Biology
Whole-Body Nanoparticle Aerosol Inhalation Exposures Jinghai Yi1,2, Bean T. Chen3, Diane Schwegler-Berry3, Dave Frazer3, Vince Castranova3, Carroll McBride1, Travis L. Knuckles1,2, Phoebe A. Stapleton1,2, Valerie C. Minarchick1,2, Timothy R. Nurkiewicz1,2 1Department of Physiology and Pharmacology, School of Medicine, West Virginia University, 2Center for Cardiovascular and Respiratory Sciences, West Virginia University, 3National Institute for Occupational Safety and Health JoVE 50263 Biology
