Virginia Espina Center for Applied Proteomics and Molecular Medicine George Mason University Biography Publications Institution JoVE Articles Virginia Espina has not added a biography. If you are Virginia Espina and would like to personalize this page please email our Author Liaison for assistance. Publications Reverse Phase Protein Arrays: Mapping the Path Towards Personalized Medicine Molecular Diagnosis & Therapy. Oct, 2014 | Pubmed ID: 25358623 Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax PloS One. 2014 | Pubmed ID: 25329596 Inhibition of Histone Deacetylase 4 Increases Cytotoxicity of Docetaxel in Gastric Cancer Cells Proteomics. Clinical Applications. Aug, 2014 | Pubmed ID: 25091122 Protein Painting Reveals Solvent-excluded Drug Targets Hidden Within Native Protein-protein Interfaces Nature Communications. 2014 | Pubmed ID: 25048602 Stratification of Clear Cell Renal Cell Carcinoma by Signaling Pathway Analysis Expert Review of Proteomics. Apr, 2014 | Pubmed ID: 24575852 Mapping Protein Signal Pathway Interaction in Sarcoma Bone Metastasis: Linkage Between Rank, Metalloproteinases Turnover and Growth Factor Signaling Pathways Clinical & Experimental Metastasis. Jan, 2014 | Pubmed ID: 23877430 Glioblastoma Cell Enrichment is Critical for Analysis of Phosphorylated Drug Targets and Proteomic-genomic Correlations Cancer Research. Dec, 2013 | Pubmed ID: 24346432 Pathologic Complete Response After Preoperative Anti-HER2 Therapy Correlates with Alterations in PTEN, FOXO, Phosphorylated Stat5, and Autophagy Protein Signaling BMC Research Notes. 2013 | Pubmed ID: 24304724 Retinal Pigment Epithelium (RPE) Exosomes Contain Signaling Phosphoproteins Affected by Oxidative Stress Experimental Cell Research. Aug, 2013 | Pubmed ID: 23669273 Elevated TNFR1 and Serotonin in Bone Metastasis Are Correlated with Poor Survival Following Bone Metastasis Diagnosis for Both Carcinoma and Sarcoma Primary Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2013 | Pubmed ID: 23493346 Attacking Breast Cancer at the Preinvasion Stage by Targeting Autophagy Women's Health (London, England). Mar, 2013 | Pubmed ID: 23477322 Laser Capture Microdissection for Protein and NanoString RNA Analysis Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23027006 Ductal Carcinoma in Situ: Challenges, Opportunities, and Uncharted Waters American Society of Clinical Oncology Educational Book / ASCO. American Society of Clinical Oncology. Meeting. 2012 | Pubmed ID: 24451705 Application of Analyte Harvesting Nanoparticle Technology to the Measurement of Urinary HGH in Healthy Individuals Journal of Sports Medicine & Doping Studies. 2012 | Pubmed ID: 24014257 Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2012 | Pubmed ID: 23045247 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Improved Data Normalization Methods for Reverse Phase Protein Microarray Analysis of Complex Biological Samples BioTechniques. Sep, 2012 | Pubmed ID: 22946677 Laser Capture Microdissection: Arcturus(XT) Infrared Capture and UV Cutting Methods Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22081345 Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22081338 Multifunctional Core-shell Nanoparticles: Discovery of Previously Invisible Biomarkers Journal of the American Chemical Society. Nov, 2011 | Pubmed ID: 21999289 Phosphoprotein Stability in Clinical Tissue and Its Relevance for Reverse Phase Protein Microarray Technology Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21901591 One-step Preservation of Phosphoproteins and Tissue Morphology at Room Temperature for Diagnostic and Research Specimens PloS One. 2011 | Pubmed ID: 21858221 Reverse Phase Protein Microarrays: Fluorometric and Colorimetric Detection Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21370072 Breast Cancer Stem Cells: a New Target for Therapy Oncology (Williston Park, N.Y.). Jan, 2011 | Pubmed ID: 21361239 A Novel Biomarker Harvesting Nanotechnology Identifies Bak As a Candidate Melanoma Biomarker in Serum Experimental Dermatology. Jan, 2011 | Pubmed ID: 21158936 What is the Malignant Nature of Human Ductal Carcinoma in Situ? Nature Reviews. Cancer. Jan, 2011 | Pubmed ID: 21150936 The Use of Hydrogel Microparticles to Sequester and Concentrate Bacterial Antigens in a Urine Test for Lyme Disease Biomaterials. Feb, 2011 | Pubmed ID: 21035184 Reverse-phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells PloS One. 2010 | Pubmed ID: 21072193 Functional Protein Network Activation Mapping Reveals New Potential Molecular Drug Targets for Poor Prognosis Pediatric BCP-ALL PloS One. 2010 | Pubmed ID: 21042412 Reverse Phase Protein Microarrays Advance to Use in Clinical Trials Molecular Oncology. Dec, 2010 | Pubmed ID: 20974554 Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells Cancer Research. Nov, 2010 | Pubmed ID: 20959469 Malignant Precursor Cells Pre-exist in Human Breast DCIS and Require Autophagy for Survival PloS One. 2010 | Pubmed ID: 20421921 The Heme Degradation Pathway is a Promising Serum Biomarker Source for the Early Detection of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20157261 Tissue is Alive: New Technologies Are Needed to Address the Problems of Protein Biomarker Pre-analytical Variability Proteomics. Clinical Applications. Aug, 2009 | Pubmed ID: 20871745 Nanoparticle Technology: Addressing the Fundamental Roadblocks to Protein Biomarker Discovery Journal of Materials Chemistry. Aug, 2009 | Pubmed ID: 20585471 Nanoparticle Technology: Amplifying the Effective Sensitivity of Biomarker Detection to Create a Urine Test for HGH Drug Testing and Analysis. Sep, 2009 | Pubmed ID: 20355230 Comparison of Global Versus Epidermal Growth Factor Receptor Pathway Profiling for Prediction of Lapatinib Sensitivity in Bladder Cancer Neoplasia (New York, N.Y.). Nov, 2009 | Pubmed ID: 19881954 Activated VEGF Receptor Shed into the Vitreous in Eyes with Wet AMD: a New Class of Biomarkers in the Vitreous with Potential for Predicting the Treatment Timing and Monitoring Response Archives of Ophthalmology. May, 2009 | Pubmed ID: 19433709 Anthrax Infection Inhibits the AKT Signaling Involved in the E-cadherin-mediated Adhesion of Lung Epithelial Cells FEMS Immunology and Medical Microbiology. Jul, 2009 | Pubmed ID: 19416348 Quantitative Cell Signalling Analysis Reveals Down-regulation of MAPK Pathway Activation in Colorectal Cancer The Journal of Pathology. Aug, 2009 | Pubmed ID: 19396842 Application of Laser Microdissection and Reverse-phase Protein Microarrays to the Molecular Profiling of Cancer Signal Pathway Networks in the Tissue Microenvironment Clinics in Laboratory Medicine. Mar, 2009 | Pubmed ID: 19389547 Reverse-phase Protein Microarrays for Theranostics and Patient Tailored Therapy Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19381949 Core-shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers PloS One. 2009 | Pubmed ID: 19274087 Concentration and Preservation of Very Low Abundance Biomarkers in Urine, Such As Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles Nano Research. Dec, 2008 | Pubmed ID: 20467576 Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer: Differential Epidermal Growth Factor Receptor (EGPR) Phosphorylation Events Associated with Mutated EGFR Compared with Wild Type Molecular & Cellular Proteomics : MCP. Oct, 2008 | Pubmed ID: 18687633 A Portrait of Tissue Phosphoprotein Stability in the Clinical Tissue Procurement Process Molecular & Cellular Proteomics : MCP. Oct, 2008 | Pubmed ID: 18667411 Molecular Network Analysis Using Reverse Phase Protein Microarrays for Patient Tailored Therapy Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 18593023 Reverse Phase Protein Microarrays for Theranostics and Patient-tailored Therapy Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18370315 Automated Laser Capture Microdissection for Tissue Proteomics Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18370312 Multiplexed Cell Signaling Analysis of Human Breast Cancer Applications for Personalized Therapy Journal of Proteome Research. Apr, 2008 | Pubmed ID: 18257519 Smart Hydrogel Particles: Biomarker Harvesting: One-step Affinity Purification, Size Exclusion, and Protection Against Degradation Nano Letters. Jan, 2008 | Pubmed ID: 18076201 Reverse Phase Protein Microarrays for Monitoring Biological Responses Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 18217695 Laser Capture Microdissection Technology Expert Review of Molecular Diagnostics. Sep, 2007 | Pubmed ID: 17892370 Reverse-phase Protein Microarrays: Application to Biomarker Discovery and Translational Medicine Expert Review of Molecular Diagnostics. Sep, 2007 | Pubmed ID: 17892368 Development of Reverse Phase Protein Microarrays for Clinical Applications and Patient-tailored Therapy Cancer Genomics & Proteomics. May-Jun, 2007 | Pubmed ID: 17878519 A Prospective Analysis of Imatinib-induced C-KIT Modulation in Ovarian Cancer: a Phase II Clinical Study with Proteomic Profiling Cancer. Jul, 2007 | Pubmed ID: 17559139 The Needle in the Haystack: Application of Breast Fine-needle Aspirate Samples to Quantitative Protein Microarray Technology Cancer. Jun, 2007 | Pubmed ID: 17487852 Phosphoprotein Pathway Mapping: Akt/mammalian Target of Rapamycin Activation is Negatively Associated with Childhood Rhabdomyosarcoma Survival Cancer Research. Apr, 2007 | Pubmed ID: 17409454 A Phase II and Pharmacodynamic Study of Gefitinib in Patients with Refractory or Recurrent Epithelial Ovarian Cancer Cancer. Apr, 2007 | Pubmed ID: 17330838 Physicochemically Modified Silicon As a Substrate for Protein Microarrays Biomaterials. Jan, 2007 | Pubmed ID: 16987550 Laser-capture Microdissection Nature Protocols. 2006 | Pubmed ID: 17406286 Accurate Diagnosis of Acute Graft-versus-host Disease Using Serum Proteomic Pattern Analysis Experimental Hematology. Jun, 2006 | Pubmed ID: 16728285 Laser Capture Microdissection Methods in Molecular Biology (Clifton, N.J.). 2006 | Pubmed ID: 16719357 Proteomic Analysis of Malignant Ovarian Cancer Effusions As a Tool for Biologic and Prognostic Profiling Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2006 | Pubmed ID: 16467090 Protein Pathway Analysis in Clinical Proteomics Using Protein Microarrays Drug Discovery Today. Technologies. 2005 | Pubmed ID: 24982012 [Development of the Protein Microarray Technique and Usefulness in Individualized Molecular Tumor Therapy]] Onkologie. Oct, 2005 | Pubmed ID: 16205105 Proteomic Analysis of Apoptotic Pathways Reveals Prognostic Factors in Follicular Lymphoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2005 | Pubmed ID: 16115925 A Transforming Growth Factor-beta Receptor-interacting Protein Frequently Mutated in Human Ovarian Cancer Cancer Research. Aug, 2005 | Pubmed ID: 16061631 Manual Exfoliation of Fresh Tissue Obviates the Need for Frozen Sections for Molecular Profiling Cancer. Dec, 2005 | Pubmed ID: 16015639 An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement Molecular Imaging. Jan-Mar, 2005 | Pubmed ID: 15967127 CSF Proteome: a Protein Repository for Potential Biomarker Identification Expert Review of Proteomics. Jan, 2005 | Pubmed ID: 15966853 Mapping Molecular Networks Using Proteomics: a Vision for Patient-tailored Combination Therapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2005 | Pubmed ID: 15908672 Pegylated, Steptavidin-conjugated Quantum Dots Are Effective Detection Elements for Reverse-phase Protein Microarrays Bioconjugate Chemistry. May-Jun, 2005 | Pubmed ID: 15898722 Expression of Xeroderma Pigmentosum A Protein Predicts Improved Outcome in Metastatic Ovarian Carcinoma Cancer. Jun, 2005 | Pubmed ID: 15844177 Adipocyte-derived Collagen VI Affects Early Mammary Tumor Progression in Vivo, Demonstrating a Critical Interaction in the Tumor/stroma Microenvironment The Journal of Clinical Investigation. May, 2005 | Pubmed ID: 15841211 Pathology of the Future: Molecular Profiling for Targeted Therapy Cancer Investigation. 2005 | Pubmed ID: 15779867 Use of Reverse Phase Protein Microarrays and Reference Standard Development for Molecular Network Analysis of Metastatic Ovarian Carcinoma Molecular & Cellular Proteomics : MCP. Apr, 2005 | Pubmed ID: 15671044 Proteomic Analysis of Human Breast Cancer Tissue with Laser-capture Microdissection and Reverse-phase Protein Microarrays Clinical Breast Cancer. Dec, 2004 | Pubmed ID: 15585078 Genomic and Proteomic Technologies for Individualisation and Improvement of Cancer Treatment European Journal of Cancer (Oxford, England : 1990). Nov, 2004 | Pubmed ID: 15541963 Biomarkers of Ovarian Tumours European Journal of Cancer (Oxford, England : 1990). Nov, 2004 | Pubmed ID: 15541961 Protein Microarray Detection Strategies: Focus on Direct Detection Technologies Journal of Immunological Methods. Jul, 2004 | Pubmed ID: 15261576 Application of Laser Capture Microdissection and Protein Microarray Technologies in the Molecular Analysis of Airway Injury Following Pollution Particle Exposure Journal of Toxicology and Environmental Health. Part A. Jun, 2004 | Pubmed ID: 15205040 Clinical Proteomics: Revolutionizing Disease Detection and Patient Tailoring Therapy Journal of Proteome Research. Mar-Apr, 2004 | Pubmed ID: 15113096 Use of Proteomic Patterns to Screen for Gastrointestinal Malignancies Surgery. Mar, 2004 | Pubmed ID: 14976472 Serum Proteomics in Cancer Diagnosis and Management Annual Review of Medicine. 2004 | Pubmed ID: 14746511 Use of Proteomic Analysis to Monitor Responses to Biological Therapies Expert Opinion on Biological Therapy. Jan, 2004 | Pubmed ID: 14680471 Molecular Diagnostics Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2003 | Pubmed ID: 14633786 Proteomic Profiling of the NCI-60 Cancer Cell Lines Using New High-density Reverse-phase Lysate Microarrays Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14623978 Protein Microarrays: Molecular Profiling Technologies for Clinical Specimens Proteomics. Nov, 2003 | Pubmed ID: 14595807 Protein Microarrays: Meeting Analytical Challenges for Clinical Applications Cancer Cell. Apr, 2003 | Pubmed ID: 12726858 Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres Virginia Espina1, Kirsten H. Edmiston2, Lance A. Liotta1 1Center for Applied Proteomics and Molecular Medicine, George Mason University, 2Virginia Surgery Associates JoVE 51926 Biology Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins Ruben Magni*1, Benjamin H. Espina*2, Lance A. Liotta1, Alessandra Luchini1, Virginia Espina1 1Center for Applied Proteomics and Molecular Medicine, George Mason University, 2Ceres Nanosciences JoVE 51789 Bioengineering
Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres Virginia Espina1, Kirsten H. Edmiston2, Lance A. Liotta1 1Center for Applied Proteomics and Molecular Medicine, George Mason University, 2Virginia Surgery Associates JoVE 51926 Biology
Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins Ruben Magni*1, Benjamin H. Espina*2, Lance A. Liotta1, Alessandra Luchini1, Virginia Espina1 1Center for Applied Proteomics and Molecular Medicine, George Mason University, 2Ceres Nanosciences JoVE 51789 Bioengineering
