Weiping Yuan State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Biography Publications Institution JoVE Articles Weiping Yuan has not added a biography. If you are Weiping Yuan and would like to personalize this page please email our Author Liaison for assistance. Publications Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming Cell Reports. Nov, 2016 | Pubmed ID: 27851966 Will Targeting PI3K/Akt/mTOR Signaling Work in Hematopoietic Malignancies? Stem Cell Investigation. 2016 | Pubmed ID: 27583254 Clinical Features, Mutations and Treatment of 104 Patients of Diamond-Blackfan Anemia in China: a Single-center Retrospective Study International Journal of Hematology. Oct, 2016 | Pubmed ID: 27329125 A Novel Lymphoid Progenitor Cell Population (LSK(low)) is Restricted by P18(INK4c) Experimental Hematology. Sep, 2016 | Pubmed ID: 27287689 Cembranoids from a Chinese Collection of the Soft Coral Lobophytum Crassum Marine Drugs. Jun, 2016 | Pubmed ID: 27271640 Tracing Haematopoietic Stem Cell Formation at Single-cell Resolution Nature. May, 2016 | Pubmed ID: 27225119 Rheb1-mTORC1 Maintains Macrophage Differentiation and Phagocytosis in Mice Experimental Cell Research. Jun, 2016 | Pubmed ID: 27163399 Enhanced Generation of Integration-free IPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors Stem Cell Reports. Jun, 2016 | Pubmed ID: 27161365 Rheb1 Promotes Tumor Progression Through MTORC1 in MLL-AF9-initiated Murine Acute Myeloid Leukemia Journal of Hematology & Oncology. Apr, 2016 | Pubmed ID: 27071307 Structurally Diverse Metabolites from the Soft Coral Sinularia Verruca Collected in the South China Sea Journal of Natural Products. Apr, 2016 | Pubmed ID: 27010413 Transcriptome Analysis Reveals a Ribosome Constituents Disorder Involved in the RPL5 Downregulated Zebrafish Model of Diamond-Blackfan Anemia BMC Medical Genomics. Mar, 2016 | Pubmed ID: 26961822 MTORC Signaling in Hematopoiesis International Journal of Hematology. May, 2016 | Pubmed ID: 26791377 Discovery of Novel INK4C Small-molecule Inhibitors to Promote Human and Murine Hematopoietic Stem Cell Ex Vivo Expansion Scientific Reports. Dec, 2015 | Pubmed ID: 26681454 Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice Cell Reports. Nov, 2015 | Pubmed ID: 26586431 [Advances in Leukemia Inhibitors Targeting PI3K/AKT/mTOR Pathway] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. Oct, 2015 | Pubmed ID: 26477776 ATF4 Plays a Pivotal Role in the Development of Functional Hematopoietic Stem Cells in Mouse Fetal Liver Blood. Nov, 2015 | Pubmed ID: 26384355 Further New Xenicanes from a Chinese Collection of the Brown Alga Dictyota Plectens Chemical & Pharmaceutical Bulletin. 2015 | Pubmed ID: 26377234 Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis Endocrinology. Nov, 2015 | Pubmed ID: 26360620 Leukemic Marrow Infiltration Reveals a Novel Role for Egr3 As a Potent Inhibitor of Normal Hematopoietic Stem Cell Proliferation Blood. Sep, 2015 | Pubmed ID: 26186938 Excessive Proliferation and Impaired Function of Primitive Hematopoietic Cells in Bone Marrow Due to Senescence Post Chemotherapy in a T Cell Acute Lymphoblastic Leukemia Model Journal of Translational Medicine. Jul, 2015 | Pubmed ID: 26183432 [Effect of ADAR1 on the Development of MLL-AF9 Induced Murine AML] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. May, 2015 | Pubmed ID: 26031523 Rictor/mTORC2 Signaling Mediates TGFβ1-induced Fibroblast Activation and Kidney Fibrosis Kidney International. Sep, 2015 | Pubmed ID: 25970154 [Research Progress in Tumorigenicity of Human Induced Pluripotent Stem Cells] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. Mar, 2015 | Pubmed ID: 25854478 Phosphoinositide-dependent Kinase 1 Regulates Leukemia Stem Cell Maintenance in MLL-AF9-induced Murine Acute Myeloid Leukemia Biochemical and Biophysical Research Communications. Apr, 2015 | Pubmed ID: 25769952 Epidermal Growth Factor Receptor and AKT1 Gene Copy Numbers by Multi-gene Fluorescence in Situ Hybridization Impact on Prognosis in Breast Cancer Cancer Science. May, 2015 | Pubmed ID: 25702787 Small-molecule Inhibitors Targeting INK4 Protein P18(INK4C) Enhance Ex Vivo Expansion of Haematopoietic Stem Cells Nature Communications. Feb, 2015 | Pubmed ID: 25692908 Rictor/mTORC2 Pathway in Oocytes Regulates Folliculogenesis, and Its Inactivation Causes Premature Ovarian Failure The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25564616 La-related Protein 4B Maintains Murine MLL-AF9 Leukemia Stem Cell Self-renewal by Regulating Cell Cycle Progression Experimental Hematology. Apr, 2015 | Pubmed ID: 25534202 Diterpenes from a Chinese Collection of the Brown Alga Dictyota Plectens Journal of Natural Products. Dec, 2014 | Pubmed ID: 25495797 Notch1-induced T Cell Leukemia Can Be Potentiated by Microenvironmental Cues in the Spleen Journal of Hematology & Oncology. Nov, 2014 | Pubmed ID: 25366136 Antioxidant N-acetyl-L-cysteine Increases Engraftment of Human Hematopoietic Stem Cells in Immune-deficient Mice Blood. Nov, 2014 | Pubmed ID: 25287706 Rictor/mammalian Target of Rapamycin 2 Regulates the Development of Notch1 Induced Murine T-cell Acute Lymphoblastic Leukemia Via Forkhead Box O3 Experimental Hematology. Dec, 2014 | Pubmed ID: 25201756 Systematic Transcriptome Analysis of the Zebrafish Model of Diamond-blackfan Anemia Induced by RPS24 Deficiency BMC Genomics. Sep, 2014 | Pubmed ID: 25189322 Rictor is Required for Early B Cell Development in Bone Marrow PloS One. 2014 | Pubmed ID: 25084011 Whole Exome Sequencing Reveals Concomitant Mutations of Multiple FA Genes in Individual Fanconi Anemia Patients BMC Medical Genomics. May, 2014 | Pubmed ID: 24885126 Graft-versus-host Disease Causes Broad Suppression of Hematopoietic Primitive Cells and Blocks Megakaryocyte Differentiation in a Murine Model Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Sep, 2014 | Pubmed ID: 24846295 Multi-gene Fluorescence in Situ Hybridization to Detect Cell Cycle Gene Copy Number Aberrations in Young Breast Cancer Patients Cell Cycle (Georgetown, Tex.). 2014 | Pubmed ID: 24621502 [The Function of AKT and Its Role in Regulation of Hematopoiesis and Malignant Hematopoiesis] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. Feb, 2014 | Pubmed ID: 24606667 [Effect of PD0332991 on Biological Activity of Hematopoietic Stem Cells in Mice] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. Feb, 2014 | Pubmed ID: 24606660 Identification of Functional Cooperative Mutations of SETD2 in Human Acute Leukemia Nature Genetics. Mar, 2014 | Pubmed ID: 24509477 Rictor/mTORC2 Protects Against Cisplatin-induced Tubular Cell Death and Acute Kidney Injury Kidney International. Jul, 2014 | Pubmed ID: 24451322 Gadd45a Regulates Hematopoietic Stem Cell Stress Responses in Mice Blood. Feb, 2014 | Pubmed ID: 24371210 QM-FISH Analysis of the Genes Involved in the G1/S Checkpoint Signaling Pathway in Triple-negative Breast Cancer Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Mar, 2014 | Pubmed ID: 24096545 Assessment of Hematopoietic Failure Due to Rpl11 Deficiency in a Zebrafish Model of Diamond-Blackfan Anemia by Deep Sequencing BMC Genomics. Dec, 2013 | Pubmed ID: 24341334 Distinct Sensitivity of CD8(+)CD4(-) and CD8(+)CD4(+) Leukemic Cell Subpopulations to Cyclophosphamide and Rapamycin in Notch1-induced T-ALL Mouse Model Leukemia Research. Sep, 2013 | Pubmed ID: 24090996 Transcriptome Analysis of the Zebrafish Model of Diamond-Blackfan Anemia from RPS19 Deficiency Via P53-dependent and -independent Pathways PloS One. 2013 | Pubmed ID: 23990987 Suppression of Cytochrome P450 Reductase Enhances Long-term Hematopoietic Stem Cell Repopulation Efficiency in Mice PloS One. 2013 | Pubmed ID: 23922855 The P53-PUMA Axis Suppresses IPSC Generation Nature Communications. 2013 | Pubmed ID: 23873265 Suppression of Cytochrome P450 Reductase Expression Promotes Astrocytosis in Subventricular Zone of Adult Mice Neuroscience Letters. Aug, 2013 | Pubmed ID: 23727388 Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity PLoS Genetics. 2013 | Pubmed ID: 23382704 Hes1 Mediates the Different Responses of Hematopoietic Stem and Progenitor Cells to T Cell Leukemic Environment Cell Cycle (Georgetown, Tex.). Jan, 2013 | Pubmed ID: 23255132 Mouse Embryonic Head As a Site for Hematopoietic Stem Cell Development Cell Stem Cell. Nov, 2012 | Pubmed ID: 23122290 Stem Cell Science on the Rise in China Cell Stem Cell. Jan, 2012 | Pubmed ID: 22226351 Long-term Survival of Exogenous Embryonic Stem Cells in Adult Bone Marrow Cell Research. Jul, 2011 | Pubmed ID: 21670744 2010 International Forum on Stem Cells (November 11-13; Tianjin, China) Stem Cell Reviews. Sep, 2011 | Pubmed ID: 21365255 Quantification of Factors Influencing Fluorescent Protein Expression Using RMCE to Generate an Allelic Series in the ROSA26 Locus in Mice Disease Models & Mechanisms. Jul, 2011 | Pubmed ID: 21324933 Rictor/mTORC2 is Essential for Maintaining a Balance Between Beta-cell Proliferation and Cell Size Diabetes. Mar, 2011 | Pubmed ID: 21266327 Tumor Growth and Angiogenesis is Impaired in CIB1 Knockout Mice Journal of Angiogenesis Research. Aug, 2010 | Pubmed ID: 20804551 CIB1 is a Regulator of Pathological Cardiac Hypertrophy Nature Medicine. Aug, 2010 | Pubmed ID: 20639889 Mice with Heterozygous Deficiency of Lipoic Acid Synthase Have an Increased Sensitivity to Lipopolysaccharide-induced Tissue Injury Journal of Leukocyte Biology. Jan, 2009 | Pubmed ID: 18845616 Characterization of Calcium- and Integrin-binding Protein 1 (CIB1) Knockout Platelets: Potential Compensation by CIB Family Members Thrombosis and Haemostasis. Nov, 2008 | Pubmed ID: 18989529 Genetic Manipulation of Megakaryocytes to Study Platelet Function Current Topics in Developmental Biology. 2008 | Pubmed ID: 17950378 CIB1 Regulates Endothelial Cells and Ischemia-induced Pathological and Adaptive Angiogenesis Circulation Research. Nov, 2007 | Pubmed ID: 17975111 Tickling the Tails: Cytoplasmic Domain Proteins That Regulate Integrin AlphaIIbbeta3 Activation Current Opinion in Hematology. May, 2007 | Pubmed ID: 17414216 CIB1 is Essential for Mouse Spermatogenesis Molecular and Cellular Biology. Nov, 2006 | Pubmed ID: 16982698 CIB1 is an Endogenous Inhibitor of Agonist-induced Integrin AlphaIIbbeta3 Activation The Journal of Cell Biology. Jan, 2006 | Pubmed ID: 16418530 Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors Wei Wen1, Jian-Ping Zhang1, Wanqiu Chen2, Cameron Arakaki2, Xiaolan Li1,2, David Baylink2, Gary D. Botimer3, Jing Xu1, Weiping Yuan1, Tao Cheng1,4,5,6,7, Xiao-Bing Zhang1,2 1State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Division of Regenerative Medicine, Department of Medicine, Loma Linda University, 3Department of Orthopaedic Surgery, Loma Linda University, 4Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, 5Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, 6Collaborative Innovation Center for Cancer Medicine, 7Tianjin Key Laboratory of Blood Cell Therapy and Technology JoVE 55091 Developmental Biology
Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors Wei Wen1, Jian-Ping Zhang1, Wanqiu Chen2, Cameron Arakaki2, Xiaolan Li1,2, David Baylink2, Gary D. Botimer3, Jing Xu1, Weiping Yuan1, Tao Cheng1,4,5,6,7, Xiao-Bing Zhang1,2 1State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Division of Regenerative Medicine, Department of Medicine, Loma Linda University, 3Department of Orthopaedic Surgery, Loma Linda University, 4Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, 5Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, 6Collaborative Innovation Center for Cancer Medicine, 7Tianjin Key Laboratory of Blood Cell Therapy and Technology JoVE 55091 Developmental Biology
