Xue-Jun Li Department of Biomedical Sciences, College of Medicine Rockford University of Illinois Biography Publications Institution JoVE Articles Xue-Jun LiAssociate Professor Xue-Jun Li received her PhD in Neurobiology from Shanghai Medical College of Fudan University in 2000. To pursue her strong interests in neurodegenerative disease and regenerative medicine, she joined the Stem Cell Research Program at the University of Wisconsin-Madison, first as a postdoctoral associate and then as an assistant scientist. In 2007, she joined the Neuroscience Department at the University of Connecticut Health Center as an assistant professor. She is also a PI of the University of Connecticut Stem Cell Institute. In February 2016, Dr. Li joined the Department of Biomedical Sciences at the College of Medicine-Rockford and the Department of Bioengineering at the University of Illinois-Chicago as an associate professor. Dr. Li's research focuses on specifying neuronal subtypes from human pluripotent stem cells (hPSCs including both human embryonic stem cells and induced pluripotent stem cells) and using these stem cell-derived neurons to study motor neuron and axonal degeneration. Dr. Li has published over 40 peer reviewed manuscripts and 3 book chapters. As the lead author, she published the seminal report on the specification of spinal motor neurons from hPSCs (Nature Biotechnology, 2005). This paradigm she developed has been widely used in motor neuron research (>800 citations; Google Scholar 01/2020). Recently, her lab has successfully established human stem cell models for spinal muscular atrophy (Cell Research, 2013; Disease Models & Mechanisms, 2016) and hereditary spastic paraplegias (Stem Cells, 2014; Human Molecular Genetics, 2014 & 2018). Her research is supported by grant funding from the National Institute of Health, the Spastic Paraplegia Foundation, the Blazer Foundation, the Connecticut Stem Cell Research Program and the ALS Association. By combining cellular, molecular, bioengineering and system approaches, research in her lab aims to understand the pathogenic mechanisms of motor neuron diseases and to develop therapeutics for the treatment of these debilitating diseases. Publications The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats Via Reducing Oxidative Stress International Journal of Molecular Sciences. Month, 2013 | Pubmed ID: 23531536 Antagonism by Ganoderma Lucidum Polysaccharides Against the Suppression by Culture Supernatants of B16F10 Melanoma Cells on Macrophage Phytotherapy Research : PTR. Mar, 2013 | Pubmed ID: 23519930 The Expression of Moesin in Astrocytoma: Correlation with Pathologic Grade and Poor Clinical Outcome Medical Oncology (Northwood, London, England). Mar, 2013 | Pubmed ID: 23315217 Induction of Oxidative Stress by Oxidized LDL Via Meprinα-activated Epidermal Growth Factor Receptor in Macrophages Cardiovascular Research. Mar, 2013 | Pubmed ID: 23250920 Recapitulation of Spinal Motor Neuron-specific Disease Phenotypes in a Human Cell Model of Spinal Muscular Atrophy Cell Research. Mar, 2013 | Pubmed ID: 23208423 Transendocardial Delivery of HGF Via Microbubbles and Ultrasound to Treat Acute Myocardial Infarction Current Gene Therapy. Feb, 2013 | Pubmed ID: 23157548 [Inverse Docking--a New Approach for Drug Targets Discovery and Identification] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Oct, 2012 | Pubmed ID: 23316610 [Progress of Aquaporin 5 on Tumor Development and Metastasis] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jun, 2012 | Pubmed ID: 23019930 [Determination of Serum IL-23 and Its Significance in Patients with Severe Chronic Hepatitis B] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology. Apr, 2012 | Pubmed ID: 23002552 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Anti-inflammatory Effects and Hepatotoxicity of Tripterygium-loaded Solid Lipid Nanoparticles on Adjuvant-induced Arthritis in Rats Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Aug, 2012 | Pubmed ID: 22884304 [Research Advances on Aquaporins and Vascular Function Regulation and Related Diseases] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Apr, 2012 | Pubmed ID: 22774635 Stomatin Inhibits Pannexin-1-mediated Whole-cell Currents by Interacting with Its Carboxyl Terminal PloS One. Month, 2012 | Pubmed ID: 22768083 Enhanced MHC Class I and Costimulatory Molecules on B16F10 Cells by Ganoderma Lucidum Polysaccharides Journal of Drug Targeting. Aug, 2012 | Pubmed ID: 22697491 Comparison of Toxicokinetic and Tissue Distribution of Triptolide-loaded Solid Lipid Nanoparticles Vs Free Triptolide in Rats European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2012 | Pubmed ID: 22677813 Roles of Vimentin and 14-3-3 Zeta/delta in the Inhibitory Effects of Heparin on PC-3M Cell Proliferation and B16-F10-luc-G5 Cells Metastasis Acta Pharmacologica Sinica. Jun, 2012 | Pubmed ID: 22669117 Curcumin Induces Autophagy to Protect Vascular Endothelial Cell Survival from Oxidative Stress Damage Autophagy. May, 2012 | Pubmed ID: 22622204 Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. Month, 2012 | Pubmed ID: 22508065 A Targeted High-efficiency Angiogenesis Strategy As Therapy for Myocardial Infarction Life Sciences. May, 2012 | Pubmed ID: 22469972 Ping-tang Recipe () Improves Insulin Resistance and Attenuates Hepatic Steatosis in High-fat Diet-induced Obese Rats Chinese Journal of Integrative Medicine. Apr, 2012 | Pubmed ID: 22457136 Ginsenoside Rg3 Attenuates Cell Migration Via Inhibition of Aquaporin 1 Expression in PC-3M Prostate Cancer Cells European Journal of Pharmacology. May, 2012 | Pubmed ID: 22426160 Hypoxia-induced Up-regulation of Aquaporin-1 Protein in Prostate Cancer Cells in a P38-dependent Manner Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. Month, 2012 | Pubmed ID: 22415096 Chinese Lacto-vegetarian Diet Exerts Favorable Effects on Metabolic Parameters, Intima-media Thickness, and Cardiovascular Risks in Healthy Men Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition. Jun, 2012 | Pubmed ID: 22412169 Activation of Nuclear Factor-κB Pathway is Responsible for Tumor Necrosis Factor-α-induced Up-regulation of Endothelin B2 Receptor Expression in Vascular Smooth Muscle Cells in Vitro Toxicology Letters. Mar, 2012 | Pubmed ID: 22207076 [Efficacy of Two Nucleoside Analogs to Treat Resistant HBeAg-negative Chronic Hepatitis B] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology. Aug, 2011 | Pubmed ID: 22097612 [Network Pharmacology and Drug Discovery] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Aug, 2011 | Pubmed ID: 22066413 [Chemical Proteomics and Discovery of Drug Targets] Yao Xue Xue Bao = Acta Pharmaceutica Sinica. Aug, 2011 | Pubmed ID: 22007509 Relationship of Carotid Intima-media Thickness and Duration of Vegetarian Diet in Chinese Male Vegetarians Nutrition & Metabolism. Month, 2011 | Pubmed ID: 21929760 Bacteriological Differences Between COPD Exacerbation and Community-acquired Pneumonia Respiratory Care. Nov, 2011 | Pubmed ID: 21605476 The Effect of Topiramate on Tumor-related Angiogenesis and on the Serum Proteome of Mice Bearing Lewis Lung Carcinoma European Journal of Pharmacology. Aug, 2011 | Pubmed ID: 21596032 Ganoderma Lucidum Polysaccharides Antagonize the Suppression on Lymphocytes Induced by Culture Supernatants of B16F10 Melanoma Cells The Journal of Pharmacy and Pharmacology. May, 2011 | Pubmed ID: 21492175 Fezf2 Regulates Telencephalic Precursor Differentiation from Mouse Embryonic Stem Cells Cerebral Cortex (New York, N.Y. : 1991). Sep, 2011 | Pubmed ID: 21330470 Promoting Effects of Ganoderma Lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes Basic & Clinical Pharmacology & Toxicology. Mar, 2011 | Pubmed ID: 20964805 [Modulation of Vesicle Trafficking by Cytoskeleton Proteins and Its Relationship with Neurological Diseases] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Feb, 2010 | Pubmed ID: 21417015 [Mechanism of Estrogen-mediated Neuroprotection: Regulation of Mitochondrial Function] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jun, 2010 | Pubmed ID: 21416974 [Role of Vimentin in Tumor Metastasis and Drug Research] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Dec, 2010 | Pubmed ID: 21416957 [Molecular Mechanisms of Diabetic Wound Healing] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Dec, 2010 | Pubmed ID: 21416956 [Drug Targets Discovery Based on Dynamic Signal Transduction Networks] Yao Xue Xue Bao = Acta Pharmaceutica Sinica. Jan, 2010 | Pubmed ID: 21351442 Metabolic Disorders in Newly Diagnosed Young Adult Female Patients with Simple Virilizing 21-hydroxylase Deficiency Endocrine. Oct, 2010 | Pubmed ID: 20978868 Puerarin Improves Insulin Resistance and Modulates Adipokine Expression in Rats Fed a High-fat Diet European Journal of Pharmacology. Dec, 2010 | Pubmed ID: 20869961 [Surgical Outcomes of Pediatric Symptomatic Epilepsy and Their Influencing Factors] Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics. Sep, 2010 | Pubmed ID: 20849719 [Phase Separation Characteristics of an Anaerobic Baffled Reactor Treating Organic Wastewater Containing Sulphate] Huan Jing Ke Xue= Huanjing Kexue / [bian Ji, Zhongguo Ke Xue Yuan Huan Jing Ke Xue Wei Yuan Hui "Huan Jing Ke Xue" Bian Ji Wei Yuan Hui.]. Jul, 2010 | Pubmed ID: 20825024 Specification of Region-specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells PloS One. Month, 2010 | Pubmed ID: 20686615 Pax6 is a Human Neuroectoderm Cell Fate Determinant Cell Stem Cell. Jul, 2010 | Pubmed ID: 20621053 Expression and Clinical Significance of EGFL7 in Malignant Glioma Journal of Cancer Research and Clinical Oncology. Nov, 2010 | Pubmed ID: 20213100 A Potential Regulatory Single Nucleotide Polymorphism in the Promoter of the Klotho Gene May Be Associated with Essential Hypertension in the Chinese Han Population Clinica Chimica Acta; International Journal of Clinical Chemistry. Mar, 2010 | Pubmed ID: 20005218 Immediate but Not Long-term Administration of Nicardipine Inhibits Tolbutamide-induced Insulin Secretion from Rat Pancreatic Beta Cells Pancreas. May, 2010 | Pubmed ID: 19959966 Curcumin Produces Neuroprotective Effects Via Activating Brain-derived Neurotrophic Factor/TrkB-dependent MAPK and PI-3K Cascades in Rodent Cortical Neurons Progress in Neuro-psychopharmacology & Biological Psychiatry. Feb, 2010 | Pubmed ID: 19879308 [A Simple Scoring System to Evaluate the Severity of Acute-on-chronic Liver Failure in Hepatitis B] Zhonghua Yi Xue Za Zhi. Dec, 2009 | Pubmed ID: 20193566 Coordination of Sonic Hedgehog and Wnt Signaling Determines Ventral and Dorsal Telencephalic Neuron Types from Human Embryonic Stem Cells Development (Cambridge, England). Dec, 2009 | Pubmed ID: 19906872 [Association Between the Serum HBV DNA Loads Normalized to Hepatic Parenchyma Cell Volume and the Liver Histopathologic Inflammation Gradings in the Immune Clearance Phase] Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. Oct, 2009 | Pubmed ID: 19874688 Lack of ABCG2 Expression and Side Population Properties in Human Pluripotent Stem Cells Stem Cells (Dayton, Ohio). Oct, 2009 | Pubmed ID: 19670287 Aquaporin-2 Regulates Cell Volume Recovery Via Tropomyosin The International Journal of Biochemistry & Cell Biology. Dec, 2009 | Pubmed ID: 19651234 [Multi-target Therapeutics and New Drug Discovery] Yao Xue Xue Bao = Acta Pharmaceutica Sinica. Mar, 2009 | Pubmed ID: 19449518 [Purinergic Signaling in Nervous System] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jan, 2009 | Pubmed ID: 19408706 Human Oligodendrocytes from Embryonic Stem Cells: Conserved SHH Signaling Networks and Divergent FGF Effects Development (Cambridge, England). May, 2009 | Pubmed ID: 19363151 Endothelium-specific GTP Cyclohydrolase I Overexpression Accelerates Refractory Wound Healing by Suppressing Oxidative Stress in Diabetes American Journal of Physiology. Endocrinology and Metabolism. Jun, 2009 | Pubmed ID: 19336662 Sinomenine Influences Capacity for Invasion and Migration in Activated Human Monocytic THP-1 Cells by Inhibiting the Expression of MMP-2, MMP-9, and CD147 Acta Pharmacologica Sinica. Apr, 2009 | Pubmed ID: 19305422 Osteopontin Mediates Dense Culture-induced Proliferation and Adhesion of Prostate Tumour Cells: Role of Protein Kinase C, P38 Mitogen-activated Protein Kinase and Calcium Basic & Clinical Pharmacology & Toxicology. Feb, 2009 | Pubmed ID: 19143755 Identification of Aquaporin-5 and Lipid Rafts in Human Resting Saliva and Their Release into Cevimeline-stimulated Saliva Biochimica Et Biophysica Acta. Jan, 2009 | Pubmed ID: 18822351 Salvianolic Acid B Protects Human Endothelial Cells from Oxidative Stress Damage: a Possible Protective Role of Glucose-regulated Protein 78 Induction Cardiovascular Research. Jan, 2009 | Pubmed ID: 18815184 [Study on the Impact Factors of Condom Usage Among the Floating Population] Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi. Nov, 2008 | Pubmed ID: 19173955 [Endoscopic Anatomy Involving the Extended Transsphenoidal Approach] Zhonghua Yi Xue Za Zhi. Aug, 2008 | Pubmed ID: 19087691 [Genetic Analysis of a Novel Aurea Mutant in Wheat] Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji. Dec, 2008 | Pubmed ID: 19073577 Induced Pluripotent Stem (iPS) Cells As in Vitro Models of Human Neurogenetic Disorders Neurogenetics. Oct, 2008 | Pubmed ID: 18791750 Serum Amyloid A Mediates the Inhibitory Effect of Ganoderma Lucidum Polysaccharides on Tumor Cell Adhesion to Endothelial Cells Oncology Reports. Sep, 2008 | Pubmed ID: 18695905 Curcumin Protects Against Glutamate Excitotoxicity in Rat Cerebral Cortical Neurons by Increasing Brain-derived Neurotrophic Factor Level and Activating TrkB Brain Research. May, 2008 | Pubmed ID: 18420184 Epinephrine Increases Phosphorylation of MAP-2c in Rat Pheochromocytoma Cells (PC12 Cells) Via a Protein Kinase C- and Mitogen Activated Protein Kinase-dependent Mechanism Journal of Proteome Research. Apr, 2008 | Pubmed ID: 18290605 Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules Stem Cells (Dayton, Ohio). Apr, 2008 | Pubmed ID: 18238853 Down-regulation of Brain-pancreas Relative Protein in Diabetic Rats and by High Glucose in PC12 Cells: Prevention by Calpain Inhibitors Journal of Pharmacological Sciences. Jan, 2008 | Pubmed ID: 18212479 The Antidepressant Effects of Curcumin in the Forced Swimming Test Involve 5-HT1 and 5-HT2 Receptors European Journal of Pharmacology. Jan, 2008 | Pubmed ID: 17942093 Human Embryonic Stem Cells for Brain Repair? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jan, 2008 | Pubmed ID: 17322002 [Expression of Hypoxia Inducible Factor-1alpha and Relationship Thereof to Apoptosis Related Protein in Non-small Cell Lung Cancer] Zhonghua Yi Xue Za Zhi. Apr, 2007 | Pubmed ID: 17650407 Oxidative Stress Mediates CoCl(2)-induced Prostate Tumour Cell Adhesion: Role of Protein Kinase C and P38 Mitogen-activated Protein Kinase Basic & Clinical Pharmacology & Toxicology. Jul, 2007 | Pubmed ID: 17577315 [Impacts of Modern Biology on Drug Discovery] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jan, 2007 | Pubmed ID: 17438949 Directed Neural Differentiation of Human Embryonic Stem Cells Via an Obligated Primitive Anterior Stage Stem Cells (Dayton, Ohio). Jun, 2007 | Pubmed ID: 17332508 Reduction in the in Vitro Expression of Brain-Pancreas Relative Protein by Oxygen and Glucose-deprivation Molecular and Cellular Biochemistry. Jan, 2007 | Pubmed ID: 16953335 [The Application of SiRNA in Therapeutics] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Oct, 2006 | Pubmed ID: 17262970 Effects of Glucose, Insulin, and Supernatant from Pancreatic Beta-cells on Brain-pancreas Relative Protein in Rat Hippocampus Neurochemical Research. Dec, 2006 | Pubmed ID: 17091403 Induced Expression of Olig2 is Sufficient for Oligodendrocyte Specification but Not for Motoneuron Specification and Astrocyte Repression Molecular and Cellular Neurosciences. Dec, 2006 | Pubmed ID: 17035043 Human Embryonic Stem Cell-derived Neural Precursors Develop into Neurons and Integrate into the Host Brain Journal of Neuroscience Research. Nov, 2006 | Pubmed ID: 16941479 Salvianolic Acid B, an Antioxidant from Salvia Miltiorrhiza, Prevents Abeta(25-35)-induced Reduction in BPRP in PC12 Cells Biochemical and Biophysical Research Communications. Sep, 2006 | Pubmed ID: 16890202 In Vitro Differentiation of Neural Precursors from Human Embryonic Stem Cells Methods in Molecular Biology (Clifton, N.J.). Month, 2006 | Pubmed ID: 16881517 Etiological Investigation of Fatal Liver Failure During the Course of Chronic Hepatitis B in Southeast China Journal of Gastroenterology. Apr, 2006 | Pubmed ID: 16741614 [The Structure and Biological Functions of A-kinase Anchor Proteins] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jul, 2005 | Pubmed ID: 16270826 Antidepressant Effects of Curcumin in the Forced Swim Test and Olfactory Bulbectomy Models of Depression in Rats Pharmacology, Biochemistry, and Behavior. Sep, 2005 | Pubmed ID: 16171853 Effect of Chronic Unpredictable Mild Stress on Brain-pancreas Relative Protein in Rat Brain and Pancreas Behavioural Brain Research. Nov, 2005 | Pubmed ID: 16154211 The Effects of Curcumin on Depressive-like Behaviors in Mice European Journal of Pharmacology. Jul, 2005 | Pubmed ID: 15987635 Melatonin Protects Against MPTP/MPP+ -induced Mitochondrial DNA Oxidative Damage in Vivo and in Vitro Journal of Pineal Research. Aug, 2005 | Pubmed ID: 15978055 GLB Prevents Tumor Metastasis of Lewis Lung Carcinoma by Inhibiting Tumor Adhesion Actions Acta Pharmacologica Sinica. Jul, 2005 | Pubmed ID: 15960897 Specification of Motoneurons from Human Embryonic Stem Cells Nature Biotechnology. Feb, 2005 | Pubmed ID: 15685164 The Protein Profile of Acetazolamide-treated Sera in Mice Bearing Lewis Neoplasm Life Sciences. Jul, 2004 | Pubmed ID: 15234186 Acetazolamide Inhibits Aquaporin-1 Protein Expression and Angiogenesis Acta Pharmacologica Sinica. Jun, 2004 | Pubmed ID: 15169637 [The Advance of RNA Interference] Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. Jan, 2004 | Pubmed ID: 15127600 Effects of Acetazolamide and Anordiol on Osmotic Water Permeability in AQP1-cRNA Injected Xenopus Oocyte Acta Pharmacologica Sinica. Jan, 2004 | Pubmed ID: 14704128 遗传性痉挛性截瘫中人类诱导多能干细胞衍生神经元的线粒体迁移与形态分析 Yongchao Mou1,2, Sukhada Mukte1, Eric Chai1, Joshua Dein3, Xue-Jun Li1,2 1Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, 2Department of Bioengineering, University of Illinois at Chicago, 3MD Program, University of Illinois College of Medicine Rockford JoVE 60548 Neuroscience 从人类多能干细胞的规范在前脑谷氨酸能神经元 Erin M. Boisvert1,2, Kyle Denton1, Ling Lei1, Xue-Jun Li1,3 1Department of Neuroscience, The University of Connecticut Health Center, 2Department of Genetics and Developmental Biology, The University of Connecticut Health Center, 3Stem Cell Institute, The University of Connecticut Health Center JoVE 50321 Neuroscience
遗传性痉挛性截瘫中人类诱导多能干细胞衍生神经元的线粒体迁移与形态分析 Yongchao Mou1,2, Sukhada Mukte1, Eric Chai1, Joshua Dein3, Xue-Jun Li1,2 1Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, 2Department of Bioengineering, University of Illinois at Chicago, 3MD Program, University of Illinois College of Medicine Rockford JoVE 60548 Neuroscience
从人类多能干细胞的规范在前脑谷氨酸能神经元 Erin M. Boisvert1,2, Kyle Denton1, Ling Lei1, Xue-Jun Li1,3 1Department of Neuroscience, The University of Connecticut Health Center, 2Department of Genetics and Developmental Biology, The University of Connecticut Health Center, 3Stem Cell Institute, The University of Connecticut Health Center JoVE 50321 Neuroscience