Yin Hua Zhang Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute Seoul National University College of Medicine Biography Publications Institution JoVE Articles Yin Hua Zhang has not added a biography. If you are Yin Hua Zhang and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of TREK-2 K(+) Channels by PI(4,5)P2: an Intrinsic Mode of Regulation by Intracellular ATP Via Phosphatidylinositol Kinase Pflügers Archiv : European Journal of Physiology. Aug, 2016 | Pubmed ID: 27283411 Erratum To: Spontaneous Inward Currents Reflecting Oscillatory Activation of Na(+)/Ca2(+) Exchangers in Human Embryonic Stem Cell-derived Cardiomyocytes Pflugers Archiv : European Journal of Physiology. Jul, 2016 | Pubmed ID: 27121022 Prognostic Role of Hypoxia-inducible Factor-1 Alpha Expression in Osteosarcoma: a Meta-analysis OncoTargets and Therapy. 2016 | Pubmed ID: 27042116 Impaired Inactivation of L-Type Ca2+ Current As a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs PloS One. 2016 | Pubmed ID: 26930604 Wall Stretch and Thromboxane A₂ Activate NO Synthase (eNOS) in Pulmonary Arterial Smooth Muscle Cells Via H₂O₂ and Akt-dependent Phosphorylation Pflügers Archiv : European Journal of Physiology. Apr, 2016 | Pubmed ID: 26729266 Spontaneous Inward Currents Reflecting Oscillatory Activation of Na⁺/Ca²⁺ Exchangers in Human Embryonic Stem Cell-derived Cardiomyocytes Pflügers Archiv : European Journal of Physiology. Apr, 2016 | Pubmed ID: 26687128 Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease Journal of Immunology (Baltimore, Md. : 1950). Oct, 2015 | Pubmed ID: 26324774 Identification of a Novel Splice Variant of Neuronal Nitric Oxide Synthase, NNOSβ, in Myofilament Fraction of Murine Cardiomyocytes Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Aug, 2015 | Pubmed ID: 26271450 Modulation of L-type Ca²⁺ Channel Activity by Neuronal Nitric Oxide Synthase and Myofilament Ca²⁺ Sensitivity in Cardiac Myocytes from Hypertensive Rat Cell Calcium. Sep, 2015 | Pubmed ID: 26115836 ROS and Endothelial Nitric Oxide Synthase (eNOS)-dependent Trafficking of Angiotensin II Type 2 Receptor Begets Neuronal NOS in Cardiac Myocytes Basic Research in Cardiology. May, 2015 | Pubmed ID: 25804308 Dexamethasone Activates Transient Receptor Potential Canonical 4 (TRPC4) Channels Via Rasd1 Small GTPase Pathway Pflügers Archiv : European Journal of Physiology. Oct, 2015 | Pubmed ID: 25502319 Attenuation of Acetylcholine Activated Potassium Current (I KACh) by Simvastatin, Not Pravastatin in Mouse Atrial Cardiomyocyte: Possible Atrial Fibrillation Preventing Effects of Statin PloS One. 2014 | Pubmed ID: 25329899 HIF-1α-mediated Upregulation of TASK-2 K⁺ Channels Augments Ca²⁺ Signaling in Mouse B Cells Under Hypoxia Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014 | Pubmed ID: 25305321 Molecular Mechanisms of Neuronal Nitric Oxide Synthase in Cardiac Function and Pathophysiology The Journal of Physiology. Aug, 2014 | Pubmed ID: 24756636 Low K⁺ Current in Arterial Myocytes with Impaired K⁺-vasodilation and Its Recovery by Exercise in Hypertensive Rats Pflügers Archiv : European Journal of Physiology. Nov, 2014 | Pubmed ID: 24557713 Myofilament Ca2+ Desensitization Mediates Positive Lusitropic Effect of Neuronal Nitric Oxide Synthase in Left Ventricular Myocytes from Murine Hypertensive Heart Journal of Molecular and Cellular Cardiology. Jul, 2013 | Pubmed ID: 23624088 Class 3 Inhibition of HERG K+ Channel by Caffeic Acid Phenethyl Ester (CAPE) and Curcumin Pflügers Archiv : European Journal of Physiology. Aug, 2013 | Pubmed ID: 23440458 Hypoxia-augmented Constriction of Deep Femoral Artery Mediated by Inhibition of ENOS in Smooth Muscle American Journal of Physiology. Cell Physiology. Jan, 2013 | Pubmed ID: 23099643 Regulation of Endothelial Nitric-oxide Synthase (NOS) S-glutathionylation by Neuronal NOS: Evidence of a Functional Interaction Between Myocardial Constitutive NOS Isoforms The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23091050 Neuronal Nitric Oxide Synthase is Up-regulated by Angiotensin II and Attenuates NADPH Oxidase Activity and Facilitates Relaxation in Murine Left Ventricular Myocytes Journal of Molecular and Cellular Cardiology. Jun, 2012 | Pubmed ID: 22484619 AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes Circulation Research. Apr, 2012 | Pubmed ID: 22456184 Requirement of Pretone by Thromboxane A(2) for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. Feb, 2012 | Pubmed ID: 22416221 Differential Effects of Acute Hypoxia on the Activation of TRPV1 by Capsaicin and Acidic PH The Journal of Physiological Sciences : JPS. Mar, 2012 | Pubmed ID: 22215506 Differential Pathways for Calcium Influx Activated by Concanavalin A and CD3 Stimulation in Jurkat T Cells Pflügers Archiv : European Journal of Physiology. Feb, 2012 | Pubmed ID: 22020731 Role of Thromboxane A₂-activated Nonselective Cation Channels in Hypoxic Pulmonary Vasoconstriction of Rat American Journal of Physiology. Cell Physiology. Jan, 2012 | Pubmed ID: 21998141 Sub-cellular Targeting of Constitutive NOS in Health and Disease Journal of Molecular and Cellular Cardiology. Feb, 2012 | Pubmed ID: 21945464 Exercise Training Increases Inwardly Rectifying K(+) Current and Augments K(+)-mediated Vasodilatation in Deep Femoral Artery of Rats Cardiovascular Research. Jul, 2011 | Pubmed ID: 21349874 Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1) The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. Dec, 2010 | Pubmed ID: 21311684 The Role of Nitric Oxide and Reactive Oxygen Species in the Positive Inotropic Response to Mechanical Stretch in the Mammalian Myocardium Biochimica Et Biophysica Acta. Jul, 2009 | Pubmed ID: 19361482 Regulation of Cardiac Na+-Ca2+ Exchanger Activity by Protein Kinase Phosphorylation--still a Paradox? Cell Calcium. Jan, 2009 | Pubmed ID: 18614228 Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. Oct, 2008 | Pubmed ID: 19967066 Stretch-activated Non-selective Cation Channel: a Causal Link Between Mechanical Stretch and Atrial Natriuretic Peptide Secretion Progress in Biophysics and Molecular Biology. Sep, 2008 | Pubmed ID: 18635250 Reduced Phospholamban Phosphorylation is Associated with Impaired Relaxation in Left Ventricular Myocytes from Neuronal NO Synthase-deficient Mice Circulation Research. Feb, 2008 | Pubmed ID: 18007024 Are Myocardial ENOS and NNOS Involved in the Beta-adrenergic and Muscarinic Regulation of Inotropy? A Systematic Investigation Cardiovascular Research. Apr, 2006 | Pubmed ID: 16545353 Role of Stretch-activated Channels on the Stretch-induced Changes of Rat Atrial Myocytes Progress in Biophysics and Molecular Biology. Jan-Apr, 2006 | Pubmed ID: 16043213 A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation Circulation Research. Sep, 2005 | Pubmed ID: 16123335 EPR Quantification of Vascular Nitric Oxide Production in Genetically Modified Mouse Models Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. May, 2004 | Pubmed ID: 15158695 [Study of 8,665 Cases of the 50 G Oral Glucose Challenge Test to Screen the Gestational Diabetes Mellitus] Zhonghua Fu Chan Ke Za Zhi. Mar, 2003 | Pubmed ID: 12816685 A Novel, Voltage-dependent Nonselective Cation Current Activated by Insulin in Guinea Pig Isolated Ventricular Myocytes Circulation Research. Apr, 2003 | Pubmed ID: 12637365 Modulation of the Na+/Ca2+ Exchanger by Isoprenaline, Adenosine, and Endothelin-1 in Guinea Pig Ventricular Myocytes Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12502609 Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling Zai Hao Zhao1, Chun Li Jin1, Ji Hyun Jang1, Yu Na Wu1, Sung Joon Kim1, Hong Hua Jin2, Lan Cui2, Yin Hua Zhang1,2,3 1Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, 2Yan Bian University Hospital, 3Institute of Cardiovascular Sciences, University of Manchester JoVE 54057 Biology
Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling Zai Hao Zhao1, Chun Li Jin1, Ji Hyun Jang1, Yu Na Wu1, Sung Joon Kim1, Hong Hua Jin2, Lan Cui2, Yin Hua Zhang1,2,3 1Department of Physiology & Biomedical Sciences, Ischemic/hypoxic Disease Institute, Seoul National University College of Medicine, 2Yan Bian University Hospital, 3Institute of Cardiovascular Sciences, University of Manchester JoVE 54057 Biology