Yonghong Wan Department of Pathology and Molecular Medicine McMaster University Biography Publications Institution JoVE Articles Yonghong Wan has not added a biography. If you are Yonghong Wan and would like to personalize this page please email our Author Liaison for assistance. Publications A Transit Time-Resolved Microflow Cytometry-Based Agglutination Immunoassay for On-Site C-Reactive Protein Detection Micromachines. Jan, 2021 | Pubmed ID: 33499089 De Novo Necroptosis Creates an Inflammatory Environment Mediating Tumor Susceptibility to Immune Checkpoint Inhibitors Communications Biology. Nov, 2020 | Pubmed ID: 33149194 Enhanced Immunotherapeutic Profile of Oncolytic Virus-based Cancer Vaccination Using Cyclophosphamide Preconditioning Journal for Immunotherapy of Cancer. 08, 2020 | Pubmed ID: 32792361 A Rational Relationship: Oncolytic Virus Vaccines As Functional Partners for Adoptive T Cell Therapy Cytokine & Growth Factor Reviews. Dec, 2020 | Pubmed ID: 32665126 Ketogenesis-generated β-hydroxybutyrate is an Epigenetic Regulator of CD8 T-cell Memory Development Nature Cell Biology. 01, 2020 | Pubmed ID: 31871320 Endogenous T Cells Prevent Tumor Immune Escape Following Adoptive T Cell Therapy The Journal of Clinical Investigation. 12, 2019 | Pubmed ID: 31682239 Preclinical Evaluation of a MAGE-A3 Vaccination Utilizing the Oncolytic Maraba Virus Currently in First-in-human Trials Oncoimmunology. 2019 | Pubmed ID: 30546947 Type I IFN Blockade Uncouples Immunotherapy-induced Antitumor Immunity and Autoimmune Toxicity The Journal of Clinical Investigation. 02, 2019 | Pubmed ID: 30422820 Development and Applications of Oncolytic Maraba Virus Vaccines Oncolytic Virotherapy. 2018 | Pubmed ID: 30538968 HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants Cell Reports. 07, 2018 | Pubmed ID: 30021162 Transforming the Prostatic Tumor Microenvironment with Oncolytic Virotherapy Oncoimmunology. 2018 | Pubmed ID: 29900060 Preclinical Development of Peptide Vaccination Combined with Oncolytic MG1-E6E7 for HPV-associated Cancer Vaccine. 04, 2018 | Pubmed ID: 29544689 A Pck1-directed Glycogen Metabolic Program Regulates Formation and Maintenance of Memory CD8 T Cells Nature Cell Biology. 01, 2018 | Pubmed ID: 29230018 Customized Viral Immunotherapy for HPV-Associated Cancer Cancer Immunology Research. Oct, 2017 | Pubmed ID: 28912369 Capitalizing on Cancer Specific Replication: Oncolytic Viruses As a Versatile Platform for the Enhancement of Cancer Immunotherapy Strategies Biomedicines. Aug, 2016 | Pubmed ID: 28536388 Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination Journal of Immunology (Baltimore, Md. : 1950). Jun, 2016 | Pubmed ID: 27183620 Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses Via an IL-1-Dependent Pathway PLoS Pathogens. 05, 2016 | Pubmed ID: 27148737 High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells PloS One. 2016 | Pubmed ID: 27064901 S6K-STING Interaction Regulates Cytosolic DNA-mediated Activation of the Transcription Factor IRF3 Nature Immunology. May, 2016 | Pubmed ID: 27043414 Mechanistic Insights into the Oncolytic Activity of Vesicular Stomatitis Virus in Cancer Immunotherapy Oncolytic Virotherapy. 2015 | Pubmed ID: 27512679 T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2015 | Pubmed ID: 26122933 Type I IFN Signaling on Dendritic Cells is Required for NK Cell-mediated Anti-tumor Immunity Innate Immunity. Aug, 2015 | Pubmed ID: 25749844 Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells Via CGAS/STING Signaling Cancer Immunology Research. Feb, 2015 | Pubmed ID: 25477253 Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War Against Cancer Frontiers in Oncology. 2014 | Pubmed ID: 24967214 Maraba Virus As a Potent Oncolytic Vaccine Vector Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2014 | Pubmed ID: 24322333 Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2014 | Pubmed ID: 24196579 Oncolytic Vesicular Stomatitis Virus Quantitatively and Qualitatively Improves Primary CD8 T-cell Responses to Anticancer Vaccines Oncoimmunology. Aug, 2013 | Pubmed ID: 24083086 Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation Journal of Immunology (Baltimore, Md. : 1950). May, 2013 | Pubmed ID: 23554310 Delivery of Viral-vectored Vaccines by B Cells Represents a Novel Strategy to Accelerate CD8(+) T-cell Recall Responses Blood. Mar, 2013 | Pubmed ID: 23325836 HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23295947 Combined Vaccination and Immunostimulatory Antibodies Provides Durable Cure of Murine Melanoma and Induces Transcriptional Changes Associated with Positive Outcome in Human Melanoma Patients Oncoimmunology. Jul, 2012 | Pubmed ID: 22754760 ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012 | Pubmed ID: 22273579 Combined MTOR Inhibition and OX40 Agonism Enhances CD8(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 22186790 Engineering Dendritic Cells to Enhance Cancer Immunotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2011 | Pubmed ID: 21468005 IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-infected Dendritic Cells Cancer Research. Apr, 2011 | Pubmed ID: 21307131 Tolerogenic Dendritic Cells and Their Potential Applications Immunology. Mar, 2011 | Pubmed ID: 21208205 Adaptive Antiviral Immunity is a Determinant of the Therapeutic Success of Oncolytic Virotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011 | Pubmed ID: 21119618 CD8+ T-cell Expansion and Maintenance After Recombinant Adenovirus Immunization Rely Upon Cooperation Between Hematopoietic and Nonhematopoietic Antigen-presenting Cells Blood. Jan, 2011 | Pubmed ID: 21088134 Potentiating Cancer Immunotherapy Using an Oncolytic Virus Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010 | Pubmed ID: 20551919 Immunotherapy Can Reject Intracranial Tumor Cells Without Damaging the Brain Despite Sharing the Target Antigen Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20237288 Processing of Tumor Antigen Differentially Impacts the Development of Helper and Effector CD4+ T-cell Responses Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2010 | Pubmed ID: 20179673 Autophagy Facilitates Major Histocompatibility Complex Class I Expression Induced by IFN-γ in B16 Melanoma Cells Cancer Immunology, Immunotherapy : CII. Feb, 2010 | Pubmed ID: 19680649 Persistence of Transgene Expression Influences CD8+ T-cell Expansion and Maintenance Following Immunization with Recombinant Adenovirus Journal of Virology. Dec, 2009 | Pubmed ID: 19759135 Vesicular Stomatitis Virus As a Novel Cancer Vaccine Vector to Prime Antitumor Immunity Amenable to Rapid Boosting with Adenovirus Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2009 | Pubmed ID: 19603003 Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2009 | Pubmed ID: 19401673 Neoadjuvant Vaccination Provides Superior Protection Against Tumor Relapse Following Surgery Compared with Adjuvant Vaccination Cancer Research. May, 2009 | Pubmed ID: 19383917 CD4+ T-cell-mediated Anti-tumor Immunity Can Be Uncoupled from Autoimmunity Via the STAT4/STAT6 Signaling Axis European Journal of Immunology. May, 2009 | Pubmed ID: 19338001 Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2008 | Pubmed ID: 28178541 Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684925 Enhanced Protein Expression by Internal Ribosomal Entry Site-driven MRNA Translation As a Novel Approach for in Vitro Loading of Dendritic Cells with Antigens Human Immunology. Jan, 2008 | Pubmed ID: 18295673 Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines is a Result of Their Ability to Engage Both CTL and IFN Gamma-producing NK Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2008 | Pubmed ID: 18059374 The Magnitude of the CD8+ T Cell Response Produced by Recombinant Virus Vectors is a Function of Both the Antigen and the Vector Cellular Immunology. Nov-Dec, 2007 | Pubmed ID: 18313652 Antigen Presentation by Exosomes Released from Peptide-pulsed Dendritic Cells is Not Suppressed by the Presence of Active CTL Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17911587 Elevated Frequencies of Self-reactive CD8+ T Cells Following Immunization with a Xenoantigen Are Due to the Presence of a Heteroclitic CD4+ T-cell Helper Epitope Cancer Research. Jul, 2007 | Pubmed ID: 17616707 On the Role of CD4+ T Cells in the CD8+ T-cell Response Elicited by Recombinant Adenovirus Vaccines Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2007 | Pubmed ID: 17375073 Cigarette Smoke Impairs NK Cell-dependent Tumor Immune Surveillance Journal of Immunology (Baltimore, Md. : 1950). Jan, 2007 | Pubmed ID: 17202355 The CD8+ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-term Immunity Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365411 Development of Cell-based Tuberculosis Vaccines: Genetically Modified Dendritic Cell Vaccine is a Much More Potent Activator of CD4 and CD8 T Cells Than Peptide- or Protein-loaded Counterparts Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2006 | Pubmed ID: 16343993 Recombinant Adenovirus Vaccines Can Successfully Elicit CD8+ T Cell Immunity Under Conditions of Extreme Leukopenia Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2006 | Pubmed ID: 16297666 Recent Advances in the Development of Adenovirus- and Poxvirus-vectored Tuberculosis Vaccines Current Gene Therapy. Oct, 2005 | Pubmed ID: 16250889 T-cell-mediated Inflammation Does Not Contribute to the Maintenance of Airway Dysfunction in Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2004 | Pubmed ID: 15286049 CTL-dependent and -independent Antitumor Immunity is Determined by the Tumor Not the Vaccine Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15100257 Vaccination-induced Autoimmune Vitiligo is a Consequence of Secondary Trauma to the Skin Cancer Research. Feb, 2004 | Pubmed ID: 14973051 TNF-alpha is a Critical Negative Regulator of Type 1 Immune Activation During Intracellular Bacterial Infection The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14755337 A Phase I Trial of Adenovector-mediated Delivery of Interleukin-2 (AdIL-2) in High-risk Localized Prostate Cancer Cancer Gene Therapy. Oct, 2003 | Pubmed ID: 14502228 High-dimensional Architectures from the Self-assembly of Lanthanide Ions with Benzenedicarboxylates and 1,10-phenanthroline Inorganic Chemistry. Aug, 2003 | Pubmed ID: 12895124 Adenoviral-mediated Gene Transfer of Lymphotactin to the Lungs of Mice and Rats Results in Infiltration and Direct Accumulation of CD4+, CD8+, and NK Cells Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. May, 2002 | Pubmed ID: 12060496 Dendritic Cell-derived IL-12 is Not Required for the Generation of Cytotoxic, IFN-gamma-secreting, CD8(+) CTL in Vivo Journal of Immunology (Baltimore, Md. : 1950). Nov, 2001 | Pubmed ID: 11673511 Role of Dendritic Cell-derived Cytokines in Immune Regulation Current Pharmaceutical Design. Jul, 2001 | Pubmed ID: 11472250 Effects of Stuffer DNA on Transgene Expression from Helper-dependent Adenovirus Vectors Journal of Virology. Oct, 1999 | Pubmed ID: 10482551 Functional Analysis of Tumor-Infiltrating Myeloid Cells by Flow Cytometry and Adoptive Transfer Andrew Nguyen*1, Omar Salem*1, Yonghong Wan1 1Department of Pathology and Molecular Medicine, McMaster University JoVE 61511 Cancer Research Culture of myeloid dendritic cells from bone marrow precursors Jeanette Boudreau1,2, Sandeep Koshy2,3, Derek Cummings2, Yonghong Wan2 1Medical Sciences Program, McMaster University, 2Centre for Gene Therapeutics, McMaster University, 3Department of Chemical Engineering, University of Waterloo JoVE 769 Biology
Functional Analysis of Tumor-Infiltrating Myeloid Cells by Flow Cytometry and Adoptive Transfer Andrew Nguyen*1, Omar Salem*1, Yonghong Wan1 1Department of Pathology and Molecular Medicine, McMaster University JoVE 61511 Cancer Research
Culture of myeloid dendritic cells from bone marrow precursors Jeanette Boudreau1,2, Sandeep Koshy2,3, Derek Cummings2, Yonghong Wan2 1Medical Sciences Program, McMaster University, 2Centre for Gene Therapeutics, McMaster University, 3Department of Chemical Engineering, University of Waterloo JoVE 769 Biology
