Ole Isacson: Development of New Therapies for Parkinson's Disease

doi:10.3791/189

Journal of Visualized Experiments

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Ole Isacson: Development of New Therapies for Parkinson's Disease

Ole Isacson
McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School


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			References

1. Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Iasacson O. Cell type specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum. Mol. Genet. 2005; 14: 1709-1725

2. Mendez I, Sanchez-Pernaute R, Cooper O, Vinuela A, Ferrari D, Bjoerklund L, Dagher A, and Isacson O. Cell type analysis of fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain 2005 128(7):1498-1510

3. Cooper O and Isacson O. Intrastiatal Transforming Growth Factor Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons. J. Neurosci., Oct 13, 2004, 24(41):8924-8931

4. Sanchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL and Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat mod of Parkinson's disease.

5. Isacson O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurology 2003 Jul; 2(7):417-24.


			Cite this Article

Isacson O (2007). Ole Isacson: Development of New Therapies for Parkinson's Disease. JoVE. 3. http://www.jove.com/index/details.stp?id=189, doi: 10.3791/189


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05/06/2007 2:21:09 PM

Anonymous responded with a statement of type: Neutral

Very Interesting

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05/30/2007 3:46:45 AM

responded with a statement of type: Neutral

This is an excellent resource and useful in a number of different ways. The research is interesting but so is the description of the drivers in science and medicine. I will be trying to incorporate presentations like this when helping medical students to make career decisions. Ioan Davies

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05/30/2007 3:49:11 AM

responded with a statement of type: Neutral

This is an excellent resource, not only from the viewpoint of the science but also because of the concise discussion about the drivers behind science and medicine. I will be trying to use resources like this when advising medical students about their career choices

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07/22/2009 3:13:25 AM

Anonymous responded with a statement of type: Neutral

nice

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10/14/2009 5:04:25 PM

veryinteresting responded with a statement of type: Neutral

i know you want to see my comment "very interesting" so here it is : very interesting

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Keywords

Medicine, Issue 3, Parkinson' disease, Neuroscience, dopamine, neuron, L-DOPA, stem cell, transplantation

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04/29/2007

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11116

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doi: 10.3791/189

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About Jove

Journal of Visualized Experiments (JoVE) is an online research journal employing visualization to increase reproducibility and transparency in biological sciences.

ISSN 1940-087X

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