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Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
George Dimopoulos
Malaria Research Institute, Bloomberg School of Public Health, John Hopkins University

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0:01 Introduction1

0:59 Severity of Malaria Worldwide59

1:27 What is Plasmodium falciparum?87

2:11 The Dengue Virus131

2:50 Life cycle of Plasmodium falciparum170

4:36 Identification of Refractory Genes276

6:37 Physiological Mechanisms Employed by A. gambiae to Kill Plasmodium 397

7:32 Physiological Mechanisms of Dengue Virus Resistance in A. aegypti452

8:20 Technological Advances Benefiting Mosquito-Borne Disease Research500

9:51 Drawbacks to Studying Laboratory-Maintained Mosquitoes591

11:12 Strategies for Preventing Malarial Transmission672

12:28 Ethical Considerations for Releasing Genetically Modified Mosquitoe748

13:33 Obstacles Preventing Disease Control Strategies813

14:54 End Credits894
Abstract
In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.
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Dimopoulos G (2007). Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes. JoVE. 5. http://www.jove.com/index/details.stp?id=233, doi: 10.3791/233
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11/02/2007 10:47:29 AM
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03/16/2009 11:31:54 AM
Shallu responded with a statement of type: Neutral

Is there any phylogenetic relationship between aedes and anopheles mosquito?

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07/04/2007

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Journal of Visualized Experiments (JoVE) is an online research journal employing visualization to increase reproducibility and transparency in biological sciences.

 

ISSN 1940-087X

 

 

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