Monash Institute of Medical Research

2 articles published in JoVE

• Biology

  
  Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography Rebecca Lim^1,2, Marcus J. Zavou¹, Phillipa-Louise Milton³, Siow Teng Chan¹, Jean L. Tan¹, Hayley Dickinson^1,2, Sean V. Murphy⁴, Graham Jenkin^1,2, Euan M. Wallace^{1,2 1}The Ritchie Centre, Monash Institute of Medical Research, ²Department of Obstetrics and Gynaecology, Monash Medical Centre, ³Animal Resource Centre, Perth, Australia, ⁴Wake Forest Institute for Regenerative Medicine The assessment of respiratory physiology has traditionally relied upon techniques, which require restraint or sedation of the animal. Unrestrained whole-body plethysmography, however, provides precise, non-invasive, quantitative analysis of respiratory physiology in animal models. In addition, the technique allows repeated respiratory assessment of mice allowing for longitudinal studies.

• Medicine

  
  A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice Jacqueline F. Donoghue¹, Oliver Bogler², Terrance G. Johns^{1 1}Monash Institute of Medical Research, ²MD Anderson Cancer Centre, University of Texas In order to evaluate novel therapeutic paradigms for the treatment of glioma, physiological relevant models are essential. We utilize an implantable guide screw procedure for establishment of intracranial xenograft models that is more rapid and safer than stereotactic approaches.