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The Journal of Visualized Experiments (JoVE) is a peer reviewed, PubMed-indexed video journal. Our mission is to increase the productivity of scientific research.

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 JoVE Clinical and Translational Medicine

Programmed Electrical Stimulation in Mice


JoVE 1730 5/26/2010

1, 1,2

1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM)

Programmed electrical stimulation provides the ability to determine conduction properties of the heart, and the possibility to induce and terminate cardiac arrhythmias using various pacing protocols. Using a transvenous catheter, intracardiac electrogram recordings can be obtained in mice following programmed electrical stimulation protocols to identify arrhythmogenic substrates.

 JoVE Clinical and Translational Medicine

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium


JoVE 1861 6/22/2010

1, 2, 1, 2, 1, 1, 1, 2, 1,2,3

1Department of Medicine, Division of Cardiology, Emory University, 2Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, 3Department of Bioinspired Science, Ewha Womans University

This describes a partial carotid ligation surgery, which causes disturbed flow conditions and subsequent atherosclerosis development (in two weeks) with intraplaque neo-vascularization (in four weeks) in the mouse common carotid artery. We also describe a novel method of RNA isolation from the carotid intima, providing high purity endothelial RNA.

 JoVE Clinical and Translational Medicine

A Novel Capsulorhexis Technique Using Shearing Forces with Cystotome


JoVE 1962 5/15/2010

1, 2, 3

1Department of Ophthalmology, Hairmyres Hospital, NHS Lanarkshire, 2Royal Devon and Exeter NHS Foundation Trust, Department of Ophthalmology, 3Department of Ophthalmology, South Devon Healthcare NHS Trust

This video demonstrates a novel capsulorhexis technique in modern cataract surgery. Capsulorhexis is the most difficult and important part of phacoemulsification surgery.

 JoVE Clinical and Translational Medicine

Murine Bioluminescent Hepatic Tumour Model


JoVE 1977 7/17/2010

1, 1, 2, 2, 3, 1, 1

1Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr. Laboratory, University College Cork, 2Department of Computer Science, University College Cork, 3South Infirmary Victoria University Hospital

This article describes a procedure for the induction of orthotopic bioluminescent liver tumours in mice, and subsequent analysis of tumour growth confined to the liver using live whole body luminescence imaging.

 JoVE Clinical and Translational Medicine

Technique to Collect Fungiform (Taste) Papillae from Human Tongue


JoVE 2201 9/18/2010

*1, 2, 3,4,5, *4,6

1Department of Basic Science and Craniofacial Biology, College of Dentistry, New York University, 2Department of Internal Medicine and Department of Psychiatry, School of Medicine, Washington University in St. Louis, 3Veterans Affairs Medical Center, 4School of Dental Medicine, Department of Biochemistry, University of Pennsylvania-School of Medicine, 5 , Monell Chemical Senses Center, 6Monell Chemical Senses Center

Knowledge of molecular mechanisms underlying gustatory transduction has recently enjoyed significant advances, largely due to using animal models. However, the wide diversity in taste sensitivity and specificity among mammals warrants studies in human tissue. We describe a biopsy technique to collect living taste cells from the papillae on human tongue.

 JoVE Editorial

September 2012: This Month in JoVE


JoVE 5022 9/01/2012

1, 2

1Department of Ophthalmology, Massachusetts Eye and Ear, 2JoVE Content Production

This September in JoVE, researchers from the School of Medicine at the Free University of Berlin demonstrate a novel method for studying how stroke patients compensate for visual field defects. To do this, our authors make use of a driving simulator complete with brakes, a steering wheel, and turn signals. Using driving simulation software and sophisticated eye tracking, researchers can compare the gaze behavior of stroke patients as they navigate through virtual driving courses with varying degrees of complexity. Though posterior cerebral artery infarction can lead to similar visual deficits in patients, some are able to navigate through the driving courses by developing compensatory eye movements, while others crash into dangerous obstacles, like wild boars. Through the analysis of compensatory gaze behavior employed by patients, our authors see great potential for using driving simulation as a tool to rehabilitate stroke patients trying to overcome the blind spots in their visual fields.

 JoVE Editorial

November 2012: This Month in JoVE


JoVE 5044 11/01/2012

1, 2

1Department of Ophthalmology, Massachusetts Eye and Ear, 2JoVE Content Production

In this issue, Oestreicher et al. show us how to isolate magnetotactic bacteria from freshwater samples, and concentrate the bacteria at one end of a glass capillary. The magnetotactic bacteria can then be visualized by light and transmission electron microscopy, and used for various other assays.

 JoVE Editorial

July 2012: This Month in JoVE


JoVE 5010 7/01/2012

1, 2

1JoVE Content Production, 2Department of Ophthalmology, Massachusetts Eye and Ear

Historically, JoVE, The Journal of Visualized Experiments, has focused primarily on biomedical research and has developed subsections for Bioengineering, Clinical and Translational Medicine, Immunology and Infection, and Neuroscience. This July, JoVE launches its Applied Physics section, which includes a range of content from Plasma Physics to Materials Science. We begin the new section with a notable article from Purdue University, where researchers in the Center for Laser-Based Manufacturing are studying.

 JoVE Editorial

June 2012: This Month in JoVE


JoVE 4467 6/01/2012

1, 2

1Department of Ophthalmology, Massachusetts Eye and Ear, 2JoVE Content Production

Back in 1905, in what is now the Czech Republic, Eduard Zirm performed the first corneal transplantation surgery (keratoplasty), which restored vision to a patient blinded by corneal injury. Today, eye banks all over the world prepare, store, and distribute donated corneas to hospitals so that thousands of sight-saving keratoplasties can be performed every year. In June 2012, JoVE has its eye on two research groups, one from Italy and the other from Michigan, who demonstrate two distinct methods for corneal graft preparation prior to transplantation.

 JoVE Editorial

August 2012: This Month in JoVE


JoVE 5016 8/01/2012

1, 2

1Department of Ophthalmology, Massachusetts Eye and Ear, 2JoVE Content Production

Traditional microscopy requires lens objectives to magnify specimens, and can involve numerous optical components like additional objectives, filters, and mirrors to refract and direct light to optical sensors. The August 2012 issue of JoVE (Journal of Visualized Experiments) is marked by the third publication from the Ozcan Lab (University of California, Los Angeles) on their lens-free "on-chip" microscopy platform, which they have pioneered.

 JoVE Clinical and Translational Medicine

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)


JoVE 1671 1/27/2010

, , , , , , , , ,

Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine

Diffuse noxious inhibitory control, temporal summation and wound hyperalgesia testing are demonstrated in the obstetric patient. These tests evaluate inhibitory and excitatory mechanisms of pain processing and are here utilized to evaluate endogenous analgesia at different time-points during pregnancy and the peripartum period to help reveal individual s risk for persistent pain.

 JoVE Clinical and Translational Medicine

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart


JoVE 1781 7/09/2010

1,2, 1,2, 1,2, 1,2, 2,3, 2

1Department of Surgery, The Ohio State University, 2Heart and Lung Research Institute, The Ohio State University, 3Department of Cardiovascular Medicine, The Ohio State University

High frequency Doppler ultrasound is a novel technology for assessing regional myocardial function. This work presents first evidence demonstrating applicability of this versatile imaging platform for the repeated measure of myocardial strain, dp/dt, and mitral regurgitation in the ischemia-reperfused (IR) murine heart.

 JoVE Editorial

May 2011: This Month in JoVE


JoVE 3449 5/04/2011

The main highlights for our May issue include methods for measuring cognition in zero gravity, isolating mosquito immune cells, engineering recombinant SARS vaccines, and detecting tumors with thermal imaging. In addition, procedures for isolating neural stem cells from human fetal brain and culturing antigen-presenting liver cells will also be released.

 JoVE Clinical and Translational Medicine

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy


JoVE 3107 10/18/2011

*, *, , *,

Department of Radiation Oncology, University of California Irvine

Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious unresolved problem has at present, no clinical recourse, and has driven our efforts to devise stem cell based therapies for the recovery of radiation-induced cognitive decrements.

 JoVE Clinical and Translational Medicine

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy


JoVE 3108 10/18/2011

, ,

Department of Radiation Oncology, University of California Irvine

Cognitive impairment resulting from the radiotherapeutic management of brain tumors represents a clinically intractable condition that adversely impacts quality of life. The capability to critically evaluate potential interventions for ameliorating radiation-induced cognitive decrements ultimately depends on the capability to undertake rigorous quantitative assessments of cognition.

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 JoVE General

FSL Constructs: A Simple Method for Modifying Cell/Virion Surfaces with a Range of Biological Markers Without Affecting their Viability


JoVE 3289 8/05/2011

1, 2, 1, 1

1Biotechnology Research Institute, AUT University and KODE Biotech Ltd, 2Shemyakin Institute of Bioorganic Chemistry RAS, Moscow, Russia

Function-Spacer-Lipid (FSL) constructs allow the surface characteristics of living cells and virions to be modified without loss of vitality. The method requires only simple contact of an FSL construct solution with a cell/virion and spontaneous and stable surface incorporation occurs.

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 JoVE Clinical and Translational Medicine

Corneal Donor Tissue Preparation for Endothelial Keratoplasty


JoVE 3847 6/12/2012

1, 2, 2, 1

1Department of Ophthalmology, University of Michigan, 2MidWest Eye Banks

Endothelial corneal transplantation is a surgical technique for treatment of posterior corneal diseases. Mechanical microkeratome dissection to prepare tissue results in thinner, more symmetric grafts with less endothelial cell loss and improved outcomes. Dissections can be performed at the eye bank prior to corneal transplantation surgery.

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 JoVE General

Large Insert Environmental Genomic Library Production


JoVE 1387 9/23/2009

, , , ,

Department of Microbiology and Immunology, University of British Columbia - UBC

Construction of a fosmid library with environmental genomic DNA isolated from the vertical depth continuum of a seasonally hypoxic fjord is described. The resulting clone library is picked into 384-well plates and archived for downstream sequencing and functional screening by the application of an automated colony picking system.

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 JoVE General

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices


JoVE 1329 9/02/2009

1, 2, 2, 2, 2, 2

1Materials Science Program, University of Wisconsin-Madison, 2Department of Biomedical Engineering, University of Wisconsin-Madison

A novel microfluidic system has been developed using the phenomenon of passive pumping and a user controlled fluid delivery system. This microfluidic system has the potential to be used in a wide variety of biological applications given its low cost, ease of use, volumetric precision, high speed, repeatability and automation.

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 JoVE Neuroscience

Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals


JoVE 3336 10/31/2011

, , , , , ,

Laboratoire d’Imagerie et de Modélisation en Neurobiologie et Cancérologie, UMR8165 Université Paris Sud 11, Paris Diderot 7 – CNRS

This article presents the protocols of intrinsic optical signals and flavoproteins autofluorescence signals imaging to map odor-evoked activities at the surface of the olfactory bulb in mice.

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