Bridging the Bio-Electronic Interface with Biofabrication

JoVE 4231 6/06/2012

Tanya Gordonov*¹, Benjamin Liba*², Jessica L. Terrell*¹, Yi Cheng³, Xiaolong Luo², Gregory F. Payne¹, William E. Bentley¹

¹Fischell Department of Bioengineering, University of Maryland, ²Institute for Bioscience and Biotechnology Research, University of Maryland, ³Department of Materials Science and Engineering, University of Maryland

This article describes a biofabrication approach: deposition of stimuli-responsive polysaccharides in the presence of biased electrodes to create biocompatible films which can be functionalized with cells or proteins. We demonstrate a bench-top strategy for the generation of the films as well as their basic uses for creating interactive biofunctionalized surfaces for lab-on-a-chip applications.