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  JoVE Biology

  
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  JoVE Neuroscience

  
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  JoVE Immunology and Infection

  
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  JoVE Clinical and Translational Medicine

  
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  JoVE Bioengineering

  
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  JoVE Applied Physics

  
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  JoVE Behavior

  
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  JoVE Environment

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JoVE Science Education

General Laboratory Techniques

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Basic Methods in Cellular and Molecular Biology

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Model Organisms I

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Model Organisms II

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Essentials of
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Essentials of Developmental Biology

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 JoVE Neuroscience

Assessing Burrowing, Nest Construction, and Hoarding in Mice

1Department of Experimental Psychology, University of Oxford


JoVE 2607

Burrowing, nesting, and hoarding are species-typical activities that mice readily perform in the laboratory. This article describes how they can be easily and cheaply assessed. These protocols are extremely sensitive to mouse strain, brain lesions and diseases. Moreover they constitute “environmental enrichment” for the mice, and embody the “Refinement” aspect of the “3 Rs”18.

 JoVE Behavior

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

1Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine


JoVE 50978

Disease, head injury, genetic modifications, and treatment of mice with drugs can have profound effects on behavior. Utilizing well-characterized and validated approaches such as marble burying and nestlet shredding, compulsive-like behaviors can be documented accurately in mice as models of human obsessive-compulsive disorder and autism spectrum disorder.

 JoVE Behavior

Shallow Water (Paddling) Variants of Water Maze Tests in Mice

1Department of Experimental Psychology, University of Oxford


JoVE 2608

Mice can swim, but many strains appear to find this activity stressful. To overcome this problem mazes have been devised where escape from shallow water is used to motivate behaviour. These have been demonstrated to support learning at least as good as the traditional and widely used Morris water maze.

 JoVE Behavior

Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software

1Department of Animal Sciences, University of Illinois at Urbana-Champaign, 2Department of Pathology, Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign


JoVE 50252

Locomotor activity (LMA) is a simple and easily performed measurement of behavior in mice. Coupling of video tracking software (VTS) and LMA allows for the improvement of specificity and sensitivity, especially when compared with the manual, line crossing method of LMA analysis. Additionally VTS allows long-term tracking of mouse LMA.

 JoVE Clinical and Translational Medicine

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

1Alberta Children's Hospital Research Institute, University of Calgary, 2Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine & John D. Dingell VA Medical Center


JoVE 51820

The modified weight-drop technique is an easy, cost-effective procedure used for the induction of mild traumatic brain injury in juvenile rats. This novel technique produces clinically relevant symptomology that will advance the study of mild traumatic brain injury (mTBI) and concussion.

 JoVE Neuroscience

Functional Analysis of the Larval Feeding Circuit in Drosophila

1Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine


JoVE 51062

The feeding circuit in Drosophila melanogaster larvae serves a simple yet powerful model that allows changes in feeding rate to be correlated with alterations in the stomatogastric neural circuitry. This circuit is composed of central serotonergic neurons that send projections to the mouth hooks as well as the foregut.

 JoVE Neuroscience

Light Preference Assay to Study Innate and Circadian Regulated Photobehavior in Drosophila Larvae

1Department of Biology, Institute of Cell and Developmental Biology, University of Fribourg


JoVE 50237

Here we describe a light-dark preference test for Drosophila larva. This assay provides information about innate and circadian regulation of light sensing and processing photobehavior.

 JoVE Biology

Creating Defined Gaseous Environments to Study the Effects of Hypoxia on C. elegans

1Department of Biochemistry, University of Washington, 2Molecular and Cellular Biology Program, University of Washington


JoVE 4088

This paper details how to use continuous-flow hypoxia chambers to generate atmospheres with defined concentrations of O2 to understand biological responses to decreased O2. This system is easy to setup and maintain, and flexible enough to suit a wide range of O2 concentrations and model systems

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