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Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive Chorea and Dementia in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; Depression; Hallucinations; and Delusions. Eventually intellectual impairment; loss of fine motor control; Athetosis; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including Seizures; Ataxia; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
 JoVE Behavior

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

1Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, 2Department of Neurology, Center for Movement Disorders and Neuromodulation, University Clinic Düsseldorf, 3Department of Neurosurgery, Functional Neurosurgery and Stereotaxy, Center for Movement Disorders and Neuromodulation, University Clinic Düsseldorf


JoVE 53466

 JoVE Biology

Purification of Transcripts and Metabolites from Drosophila Heads

1Department of Neurology, McKnight Brain Institute, University of Florida, 2Department of Entomology and Nematology, University of Florida, 3Genetics Institute, Department of Molecular Genetics and Microbiology, University of Florida, 4McKnight Brain Institute, Department of Neuroscience, Genetics Institute, Center for Translational Research on Neurodegenerative Diseases, and Center for Movement Disorders and Neurorestoration, University of Florida


JoVE 50245

 JoVE Developmental Biology

Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells

1Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health


JoVE 52298

 JoVE Neuroscience

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

1Division of Biology, California Institute of Technology, 2Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology, Johns Hopkins University School of Medicine, 3Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 4Department of Radiation Oncology, University Of Washington Medical Center, 5Institute for Cell Engineering and High-Throughput Biology Center, Johns Hopkins University School of Medicine


JoVE 50716

 Science Education: Essentials of Behavioral Science

An Introduction to Motor Control

JoVE Science Education

Motor control involves integration and processing of sensory information by our nervous system, followed by a response through our skeletal system to perform a voluntary or involuntary action. It is vital to understand how our neuroskeletal system controls motor behavior in order to evaluate injuries pertaining to general movement, reflexes, and coordination. An improved understanding of motor control will help behavioral neuroscientists in developing useful tools to treat motor disorders, such as Parkinson's or Huntington's disease. This video briefly reviews the neuroanatomical structures and connections that play a major role in controlling motion. Fundamental questions currently being asked in the field of motor control are introduced, followed by some of the methods being employed to answer those questions. Lastly, the application sections reviews a few specific experiments conducted in neuroscience labs interested in studying this phenomenon.

 JoVE Biology

Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry

1Laboratoire de Neurophysiologie (CP601), ULB Neuroscience Institute (UNI), Université Libre de Bruxelles, 2Medical Molecular Sciences, Centre for Biomolecular Sciences, University of Nottingham, 3School of Life Sciences, University of Nottingham, 4Division of Cancer and Stem Cells, Centre for Biomolecular Sciences, School of Medicine, University of Nottingham


JoVE 54416

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