A micropunching lithography approach is developed to generate micro- and submicron-patterns on top, sidewall and bottom surfaces of polymer substrates. It overcomes the obstacles of patterning conducting polymers and generating sidewall patterns. This method allows rapid fabrication of multiple features and is free of aggressive chemistry.
A versatile plasma lithography technique has been developed to generate stable surface patterns for guiding cellular attachment. This technique can be applied to create cell networks including those that mimic natural tissues and has been used for studying several, distinct cell types.
Published June 14, 2011. Keywords: Bioengineering, Cell Network, Surface Patterning, Self-Organization, Developmental Biology, Tissue Engineering, Nanopattern, Micropattern, Self-Assembly, Cell Guidance, Neuron
1Laboratoire Interdisciplinaire Carnot de Bourgogne CNRS-UMR 6303, Université de Bourgogne, 2Department of Optics and Optical Engineering, University of Science and Technology of China, 3CEMES, CNRS-UPR 8011
Silver nanowires can simultaneously transport electrons and optical information in the form of surface plasmons. A procedure is described here to realize such a shared circuitry and the limitations at propagating both information carriers are evaluated.
Published December 11, 2013. Keywords: Physics, light transmission, optical waveguides, photonics, plasma oscillations, plasma waves, electron motion in conductors, nanofabrication, Information Transport, plasmonics, Silver Nanowires, Leakage radiation microscopy, Electromigration
A method for the assembly of adhesive and soluble gradients in a microscopy chamber for live cell migration studies is described. The engineered environment combines antifouling surfaces and adhesive tracks with solution gradients and therefore allows one to determine the relative importance of guidance cues.
Published April 4, 2013. Keywords: Bioengineering, Microbiology, Cellular Biology, Biochemistry, Molecular Biology, Biophysics, Cell migration, live cell imaging, soluble and adherent gradients, microcontact printing, dip pen lithography, microfluidics, RGD, PEG, biotin, streptavidin, chemotaxis, chemoattractant, imaging
Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
1Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Juelich GmbH
In this protocol the fabrication, setup and basic operation of a microfluidic picoliter bioreactor (PLBR) for single-cell analysis of prokaryotic microorganisms is introduced. Industrially relevant microorganisms were analyzed as proof of principle allowing insights into growth rate, morphology, and phenotypic heterogeneity over certain time periods, hardly possible with conventional methods.
Published December 6, 2013. Keywords: Bioengineering, Soft lithography, SU-8 lithography, Picoliter bioreactor, Single-cell analysis, Polydimethylsiloxane, Corynebacterium glutamicum, Escherichia coli, Microfluidics, Lab-on-a-chip
Use of photonic crystal slow light waveguides and cavities has been widely adopted by the photonics community in many differing applications. Therefore fabrication and characterization of these devices are of great interest. This paper outlines our fabrication technique and two optical characterization methods, namely: interferometric (waveguides) and resonant scattering (cavities).
Published November 30, 2012. Keywords: Physics, Optics and Photonics, Astronomy, light scattering, light transmission, optical waveguides, photonics, photonic crystals, Slow-light, Cavities, Waveguides, Silicon, SOI, Fabrication, Characterization
Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, 2School of Medicine, University of California, San Francisco, 3Department of Radiology and Biomedical Imaging, UCSF Medical Center, 4University of California, San Francisco, 5Hansen Medical, Mountain View, CA
Current applied to an endovascular microcatheter with microcoil tip made by laser lathe lithography can achieve controllable deflections under magnetic resonance (MR) guidance, which may improve speed and efficacy of navigation of vasculature during various endovascular procedures.
Published April 4, 2013. Keywords: Biomedical Engineering, Medicine, Bioengineering, Molecular Biology, Anatomy, Physiology, Surgery, Delivery of Health Care, Health Services Research, catheter, microcatheter, deflection, navigation, interventional, Magnetic Resonance Imaging, MRI, lithography, imaging, vascular, endovascular procedures, clinical techniques
The fabrication of electrically addressable, high-aspect-ratio (> 1000:1) metal nanowires separated by gaps of single nanometers using either sacrificial layers of aluminum and silver or self-assembled monolayers as templates is described. These nanogap structures are fabricated without a clean room or any photo- or electron-beam lithographic processes by a form of edge lithography known as nanoskiving.
Published May 13, 2013. Keywords: Chemistry, Materials Science, Chemical Engineering, Electrical Engineering, Physics, Nanotechnology, nanodevices (electronic), Nanoskiving, nanogaps, nanofabrication, molecular electronics, nanowires, fabrication, etching, ultramicrotome, scanning electron microscopy, SEM
Nanomoulding of Functional Materials, a Versatile Complementary Pattern Replication Method to Nanoimprinting
1Institute of Microengineering (IMT), Photovoltaics and Thin Film Electronics Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), 2Department of Electrical Engineering and Computer Sciences, University of California, Berkeley
We describe a nanomoulding technique which allows low-cost nanoscale patterning of functional materials, materials stacks and full devices. Nanomoulding can be performed on any nanoimprinting setup and can be applied to a wide range of materials and deposition processes.
Published January 23, 2013. Keywords: Materials Science, Nanotechnology, Mechanical Engineering, Electrical Engineering, Computer Sciences, Physics, dielectrics (electronic application), light emitting diodes (LED), lithography (circuit fabrication), nanodevices (electronic), optoelectronics (applications), photoelectric devices, semiconductor devices, solar cells (electrical design), Surface patterning, nanoimprinting, nanomoulding, transfer moulding, functional materials, transparent conductive oxides, microengineering, photovoltaics
1Chemical and Biomolecular Engineering Department, Johns Hopkins University
A procedure for creating and imaging capillary bridges in slit-pore geometry is presented. The creation of capillary bridges relies on the formation of pillars to provide a directional physical and chemical heterogeneity to pin the fluid. Capillary bridges are formed and manipulated using microstages and visualized using a CCD camera.
Published January 9, 2014. Keywords: Physics, Microfluidics, Surface Properties, Capillary Action, Surface Tension, fluid forces, fluidics, polydimethylsiloxane molding, self-assembled monolayers, surface patterning, imprint transfer lithography, surface tension, capillarity, wetting