Nerve Sheath Neoplasms:
Neoplasms which arise from nerve sheaths formed by Schwann cells in the Peripheral nervous system or by Oligodendrocytes in the Central nervous system. Malignant peripheral nerve sheath tumors, Neurofibroma, and Neurilemmoma are relatively common tumors in this category.
JoVE Clinical and Translational Medicine
Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
1Department of Pathology, University of Alabama at Birmingham - UAB, 2Department of Radiology, University of Alabama at Birmingham - UAB, 3Department of Cell Biology and Neurobiology, University of Alabama at Birmingham - UAB
A method for reliably grafting luciferase-tagged human malignant peripheral nerve sheath tumor cells into the sciatic nerve of immunodeficient mice is described. The use of bioluminescence imaging to demonstrate proper establishment of tumor grafts and criteria for random segregation of animals into study groups are also discussed.
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