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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets


JoVE 3373 11/02/2011

Helen Tran, Sarah L. Gael, Michael D. Connolly, Ronald N. Zuckermann

Molecular Foundry, Lawrence Berkeley National Laboratory

A simple and general manual peptoid synthesis method involving basic equipment and commercially available reagents is outlined, enabling peptoids to be easily synthesized in most laboratories. The synthesis, purification and characterization of an amphiphilic peptoid 36mer is described, as well as its self-assembly into highly-ordered nanosheets.

 

November 2011: This Month in JoVE


JoVE 4025 11/01/2011

Aaron Kolski-Andreaco

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