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  JoVE Behavior

  
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  JoVE Environment

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JoVE Science Education

General Laboratory Techniques

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Basic Methods in Cellular and Molecular Biology

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Model Organisms I

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Model Organisms II

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Essentials of
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 JoVE Neuroscience

Peering into the Dynamics of Social Interactions: Measuring Play Fighting in Rats

1Department of Neuroscience, University of Lethbridge


JoVE 4288

Play fighting in the rat involves attack and defense of the nape of the neck, which if contacted, is gently nuzzled with the snout. Because the movements of one animal are countered by the actions of its partner, play fighting is a complex, dynamic interaction. This dynamic complexity raises methodological problems about what to score for experimental studies. We present a scoring schema that is sensitive to the correlated nature of the actions performed. Two experiments illustrate how these measurements can be used to detect the effect of brain damage on play fighting even when there is no effect on overall playfulness. That is, the schema presented here is designed to detect and evaluate changes in the content of play following an experimental treatment.

 JoVE Behavior

Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

1Departments of Paediatrics and Clinical Neurosciences, Alberta Children's Hospital Research Institute, University of Calgary Faculty of Medicine, 2Department of Psychology, Neuroscience Program, Trinity College


JoVE 50791

Inchworming is a highly repetitive synchronous digging motion displayed by BTBR T+ Itpr3tf/J (BTBR) mice when placed in a testing cage with sufficient sawdust bedding. The procedure is a modification of the juvenile social interaction protocol and is used here to assess repetitive motor stereotypies relevant to Autism Spectrum Disorder.

 JoVE Behavior

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

1Department of Clinical Psychology, University of Amsterdam


JoVE 52151

Disrupting reconsolidation is a promising approach to dampen the behavioral expression of fear memory in patients with anxiety disorders or posttraumatic stress disorder. In a series of human fear conditioning studies we showed that disrupting reconsolidation by the noradrenergic β-blocker propranolol is very effective in erasing conditioned fear responding.

 JoVE Clinical and Translational Medicine

Measuring the Strength of Mice

1Department of Experimental Psychology, University of Oxford


JoVE 2610

Deficits in muscular strength occur in many clinical conditions such as motor neuron disease. The inverted screen and weight lifting tests described here measure strength in mice almost exclusively, with minimal influence of factors such as coordination.

 JoVE Neuroscience

Assessing Burrowing, Nest Construction, and Hoarding in Mice

1Department of Experimental Psychology, University of Oxford


JoVE 2607

Burrowing, nesting, and hoarding are species-typical activities that mice readily perform in the laboratory. This article describes how they can be easily and cheaply assessed. These protocols are extremely sensitive to mouse strain, brain lesions and diseases. Moreover they constitute “environmental enrichment” for the mice, and embody the “Refinement” aspect of the “3 Rs”18.

 JoVE Neuroscience

Measuring Motor Coordination in Mice

1Department of Experimental Psychology, University of Oxford


JoVE 2609

Protocols are presented for two established motor coordination tasks, the accelerating rotarod and horizontal bar, also two tests developed in Oxford recently, the static rods and parallel bars. These tests can detect motor impairments potentially of interest in their own right, as well as being possible variables in tests of other areas of behavior.

 JoVE Neuroscience

Hyponeophagia: A Measure of Anxiety in the Mouse

1Department of Experimental Psychology, University of Oxford


JoVE 2613

Mice and rats, due to their innate cautiousness, are initially slow in consuming a novel food, particularly in a novel place. This hyponeophagia can readily be measured in the laboratory, even though laboratory animals are much less anxious than their wild counterparts

 JoVE Behavior

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress

1Department of Behavioral Physiology, Center for Behavior and Neurosciences, University Groningen, 2Radboud University Nijmegen


JoVE 4367

This video shows the resident-intruder paradigm in rats. This test is a standardized method to measure offensive aggression, defensive behavior and violence in a semi-natural setting. The use of the paradigm for social stress experiments is explained as well.

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