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嗨 - C：一个方法研究基因组的三维架构。
Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization (FISH) with PNA Probes in Caenorhabditis elegans
Journal (Biology)
Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization (FISH) with PNA Probes in Caenorhabditis elegans
Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Journal (Biology)
Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
 
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嗨 - C：一个方法研究基因组的三维架构。

Article DOI: 10.3791/1869-v • 22:27 min • May 6th, 2010
May 6th, 2010 •
*1, *2,3,4,5, *2, 6, 2, 3,6, 1, 2,7,8
1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 2Broad Institute of Harvard and Massachusetts Institute of Technology, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, 4Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, 5Department of Applied Mathematics, Harvard University, 6Department of Physics, Massachusetts Institute of Technology, 7Department of Systems Biology, Harvard Medical School, 8Department of Biology, Massachusetts Institute of Technology
* These authors contributed equally

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的HI - C的方法，允许不带偏见，全基因组鉴定（1）染色质相互作用。您好- C的夫妇接近结扎和大规模并行测序。由此产生的数据可以用来研究基因组架构在多尺度的初步结果确定，如染色体领土，染色质开放式和封闭式的隔离，在megabase规模和染色质结构的特点。

Tags

细胞生物学，发行39，染色体构象捕获，染色质结构，Illumina的配对末端测序，高分子物理。
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