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Journal / Biology / Oi-C: um método para estudar a arquitetura…
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Biology

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Harvesting and Preparing Drosophila Embryos for Electrophysiological Recording and Other Procedures
Journal (Biology)
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Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
Journal (Biology)
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Oi-C: um método para estudar a arquitetura tridimensional de Genomas.

Article DOI: 10.3791/1869-v • 22:27 min • May 6th, 2010
May 6th, 2010 •
*1, *2,3,4,5, *2, 6, 2, 3,6, 1, 2,7,8
1Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 2Broad Institute of Harvard and Massachusetts Institute of Technology, 3Division of Health Sciences and Technology, Massachusetts Institute of Technology, 4Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, 5Department of Applied Mathematics, Harvard University, 6Department of Physics, Massachusetts Institute of Technology, 7Department of Systems Biology, Harvard Medical School, 8Department of Biology, Massachusetts Institute of Technology
* These authors contributed equally

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O método de Hi-C permite a identificação imparciais, de todo o genoma de interações cromatina (1). Oi-C casais ligadura proximidade e seqüenciamento massivamente paralelo. Os dados resultantes podem ser usados ​​para estudar a arquitetura genômica em múltiplas escalas: resultados iniciais identificadas características como territórios cromossomo, a segregação da cromatina abertas e fechadas, e estrutura da cromatina na escala megabase.

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Biologia Celular Edição 39 a captura de conformação cromossômica a estrutura da cromatina o seqüenciamento End Illumina emparelhados polímero física.
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